Biogenic amines, manganese

Manganese toxicity has been observed in miners exposed to high levels of Mn02 dust. The neurological symptoms mimic Parkinson s disease. Major changes were observed in the biogenic amines, dihydroxyphenylalanine (DOPA), and phenylalanine. Restoration of appropriate levels of these bioamines alleviated the symptoms. Chelation therapy has not been demonstrated as an effective strategy. ... 

Bonilla E, Prasad AL. 1984. Effects of chronic manganese intake on the levels of biogenic amines in rat brain regions. Neurobehav Toxicol Teratol 6 341-344. 

Eriksson H, Lenngren S, Heilbronn E. 1987a. Effect of long-term administration of manganese on biogenic amine levels in discrete striatal regions of rat brain. Arch Toxicol 59 426-431. 

Komura J, Sakamoto M. 1992b. Effects of manganese forms on biogenic amines in the brain and behavioral alterations in the mouse Eong-term oral administration of several manganese compounds. Environ Res 57 34-44. 

Komura J and Sakamoto M. 1994. Chronic oral administration of methylcyclopentadienyl manganese tricarbonyl altered brain biogenic amines in the mouse comparison with inorganic manganese. Toxicol Eett 73 65-73. 

Subhash MN, Padmashree TS. 1991. Effect of manganese on biogenic amine metabolism in regions of the rat brain. Food Chem Toxicol 29 579-582. 

The biochemical basis for many of the psychotropic and neurological effects of manganese intoxication are increasingly well-documented in terms of altered neuro-transmitters, receptors, and enzyme activities [530], Alessio et al. [531] have documented the interference of Mn(II) with the neuro-endocrinal system. Research by Bonilla and Prasad [532] and Eriksson et al. [533] indicate changes in levels of biogenic amines in discrete... 

Papavasiliou and colleagues demonstrated an intracellular increase in the concentration of manganese in liver tissue after the administrations of DA, L-epinephrine, or DL-isoproterenol. It was also observed that this effect was mediated through an intracellular increase in cyclic 3, 5 -adenosine monophosphate. Although the importance of these studies in relation to manganese encephalopathy could not be evaluated, it became clear that a correlation existed between manganese metabolism and biogenic amines. 

Changes in the concentration of various neurotransmitters in the brain of chronically exposed animals led the investigators to study the effect of manganese on various enzymes involved in the metabolism of biogenic amines. Rats treated with MnCl2-4H20 (8 mg/kg/d) intraperitoneally for a period of 120 d showed a significant reduction in the activity of acetylcholine esterase in cere-... 

Effects of Manganese Exposure on Biogenic Amines in the Central Nervous System of Animals... 

Chandra, S. V., Srivastava, R. S. and Shukla, G. S. (1979) Regional distribution of metals and biogenic amines in the brain of monkeys exposed to manganese, Toxicol. Lett. 4 189-192. 

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