Major Changes

If the analytical method survives all of the above criteria (suitably modified to match the situation), it is considered to be under control. Changing major factors (instrument components, operators, location, etc.) means revalidation, generally along the same lines. 

Solutions to America s interrelated problems of scarce energy, clean environment, and price inflation require a comprehensive analysis of the economic consequences of policy alternatives before policy is changed. Major policy changes, in the face of resource scarcities, are greatly modifying the structure of the economy. Structural changes are resulting in totally new economic trends in supplies, demands, and prices. 

Different studies have focused on the biosynthesis of aroma compounds during MLF and the concomitant organoleptic consequences (Laurent et al. 1994). Maicas et al. (1999) demonstrated that MLF noticeably changes major and minor volatile... 

The data plotted in Figure 2 show an example of one such discontinuous or radical change. Major product and process innovations by the Ford Motor Company are plotted over the period from 1900-1940. [8] The period 1900-1909 saw Ford introduce seven different models of automobile with cumulative production volume slightly exceeding 40,000 units. In 1908, the... 

One student who changed majors several times to ensure he fits in highlights the agency students have in defining their experiences, Once I got more involved with the [student] societies... I saw the opportunity to do more...I never spent one semester without being involved with clubs. 

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