Halloysite nanotubules

Halloysite Nanotubules, a Novel Substrate for the Controlled Delivery of Bioactive Molecules... 

We describe below the use of halloysite nanotubules for entrapment and the subsequent release of three drugs Nifedipine (anti-anginal), Furosemide (anti-hypertension and diuretic), and Dexamethasone (synthetic corticosteroid). To increase the loading of these poorly soluble drugs in the tubules, we loaded them into a water-alcohol co-solvent solution (0, 10, and 50% ethanol). 

In conclusion, one can load drug molecules into halloysite nanotubules and get their slow release, typically during 5-30 hours. To achieve slower release kinetics, one needs a range of materials to act as stoppers on the ends of the tubules. 

Fig. 14.19 (A) SEM image of cracks in a dry layer of paint with inclusion of halloysite nanotubules containing antifouling agent ...

Balkundi, S., Veerabadran, N., Lvov, Y. and Price, R. (2007) Protein Controlled Release from Halloysite Nanotubules. Journal of Controlled Release 90,766-771. 

Du, M.Gao and Jia, D. (2006) Thermal stability and flame retardant effect of halloysite nanotubules on Poly(propylene). European Polymer Journal, 42, 1362-1369. 

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