Bioactive Glass Scaffolds

Bioactive glass scaffolds for bone regeneration. Elements, 3, 393-399. 

Optical images of von Kossa-stained sections of tbe defects implanted with the four groups of scaffolds at 12 weeks are shown in Fig. 5. The total von Kossa-positive area (the dark-stained area) within the defect indicated the presence of phosphate materials due to mineralized bone and to HA due to conversion of the bioactive glass scaffolds. The 13-93B3 glass appeared to be fully converted to HA within 6 weeks (results not shown). In comparison, the 13-93 glass was only partially converted at 12 weeks. 

Q. Fu, M. N. Rahaman, B. S. Bal, L. F. Bonewald, K. Kuroki, and R. F. Brown, Silicate, Borosilicate, and Borate Bioactive Glass Scaffolds with Controllable Degradation Rate for Bone Tissue Engineering Applications. II. In Vitro and In Vivo Biological Evaluation, J. Biomed. Mater. Res. A, 95, 172-9 (2010). 

Calvarial Defects Implanted with Bioactive Glass Scaffolds, J. Biomed. Mata Res. A, 100, 3267-75 (2012). 

A. M. Dehormanh and M. N. Rahaman, Direct-write Assembly of Silicate and Borate Bioactive Glass Scaffolds for Bone Repair, J. Eur. Ceram. Soc., 32, 3637-46 (2012). 

L. L. (2006) Optimising bioactive glass scaffolds for bone tissue engineering. Biomaterials, 27, 964-973. 

Gough, JJ ., Jones, J.R., and Hench, LX. (2004) Nodule formation and mineralisation of human primary osteoblasts cultured on a porous bioactive glass scaffold. Biomaterials, 25, 2039-2046. 

Hench, L.L. (2007) Extracellular matrix formation and mineralization on a phosphate-free porous bioactive glass scaffold using primary human osteoblast (HOB) cells. Biomaterials, 28,... 

Coelho, M.D. and Pereira, MA4. (2005) Sol-gel synthesis of bioactive glass scaffolds for tissue engineering effect of surfectant type and concentration. /. Biomed. Mater. Res. Part B, 75B, 451-456. 

Wang, S. and Jain, H. (2010) High surface area nanomacroporous bioactive glass scaffold for hard tissue engineering. /. 

Fu, Q., Saiz, E., Rahaman, M.N., Tomsia, A.P., 2011. Bioactive glass scaffolds for bone tissue engineering state of the art and future perspectives. Materials Science and Engineering C 31, 1245-1256. 

Olalde, B., Garmendia, N., Saez-Martinez, V., Argarate, N., Nooeaid, P., Morin, F., Boccaccini, A.R., 2013. Multifunctional bioactive glass scaffolds coated with layers of polyfD, L-lactide-co-glycolide) and poly(n-isopropylacrylamide-co-acrylic acid) microgels loaded with vancomycin. Mater. Sci. Eng. C Mater. Biol. Appl. 33, 3760-3767. 

Zhao, S., Zhang, J., Zhu, M., Zhang, Y, Liu, Z., Tao, C., Zhu, Y., Zhang, C., 2015b. Three-dimensional printed strontium-containing mesoporous bioactive glass scaffolds for repairing rat critical-sized calvarial defects. Acta Biomater. 12, 270-280. 

Ordered mesoporous silica have already been studied as carriers for drug delivery [1,2] recently, their use has also been proposed in bone tissue engineering [3,4], in combination with bioactive glass-ceramic scaffolds [5,6]. The kinetics of ibuprofen release in SBF [7] from MCM-41 silica with similar pore diameter has shown puzzling discontinuities [3,6,8] aim of the present work is to assess whether these anomalies may be related to structural changes in the MCM-41 mesoporous spheres under the adopted conditions. 

Bellucci, D., Cannillo, A., and Sola, A. (2011) A new potassium-based bioactive glass sintering behaviour and possible applications for bioceramic scaffolds. Ceram. Int., 37, 145-157. 

Figure 2. Stress-strain curve for the PLGA-coated bioactive glass-ceramic scaffold.

Figure 3. SEM micrographs with different magnifications (A and B) of BMSCs cultured onto the PLGA-coated bioactive glass-ceramic scaffold cultured at day 21.

M.M. Pereira, J.R. Jones, L.L. Bench, Bioactive Glass and Hybrid Scaffolds Prepared by Sol-Gel Method for Bone Tissue Engineering, Advances in Applied Ceramics Structural, Functional Bioceramics, 104(1), 35-42 (2005). 

PREPARATION AND CHARACTERISATION OF PLGA-COATED 517 POROUS BIOACTIVE GLASS-CERAMIC SCAFFOLDS FOR SUBCHONDRAL BONE TISSUE ENGINEERING... 

Peter, M., Binulal, N. S., Nair, S. V., Selvamurugan, N., Tamura, H., Jayakumar, R. (2010). Novel biodegradable chitosan-gelatin/nano-bioactive glass ceramic composite scaffolds for alveolar bone tissue engineering, Chem./-no. 1.1.58. 353-361. 

R.M. Day, A.R. Boccaccini, S. Shurey, J.A. Roether, A. Forbes, L.L. Hench, et al.. Assessment of polyglycolic add mesh and bioactive glass for soft-tissue engineering scaffolds. Biomaterials 25 (2004) 5857-5866. 

IN VIVO EVALUATION OF SCAFFOLDS WITH A GRID-LIKE MICROSTRUCTURE COMPOSED OF A MIXTURE OF SILICATE (13-93) AND BORATE (13-93B3) BIOACTIVE GLASSES... 

X. Liu, M. N. Rahaman, G. E. Hiimas, and B. S. Bal, Mechanical Properties of Bioactive Glass (13-93) Scaffolds Fabricated by Robotic Deposition for Structural Bone Repair, Acta Biotnater., 9, 7025-34 (2013). 

Y. Gu, W. Huang, M. N. Rahaman, and D. E. Day, Bone Regeneration in Rat Calvarial Defects Implanted with Fibrous Scaffolds Composed of a Mixture of Silicate and Borate Bioactive Glasses, Acta Biotnater., 9, 9126-36 (2013). 

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