Hybrid scaffolds

Li Z, Ramay HR, Hauch KD et al (2005) Chitosan-alginate hybrid scaffolds for bone tissue engineering. Biomaterials 26 3919-3928... 

The generation of polycyclic systems from a monosaccharide (hybrid scaffolds) is a means of further increasing structural diversity [8,83,84,85,86,87,88,89,90,91,92,93,94,95,96]. Hirschmann, Smith and co-workers, for example, synthesised chimeric scaffolds such as 145 and 146 (O Fig. 12) that are hybrids of -D-glucopyranose and benzodiazepines and... 

M.M. Pereira, J.R. Jones, L.L. Bench, Bioactive Glass and Hybrid Scaffolds Prepared by Sol-Gel Method for Bone Tissue Engineering, Advances in Applied Ceramics Structural, Functional Bioceramics, 104(1), 35-42 (2005). 

Hybrid PCL/ Culture of rat More cell Hybrid scaffolds Prabhakaran... 

Jiankang H, Dichen L, Yaxiong L et al (2009) Preparation of chitosan-gelatin hybrid scaffolds with well-organized microstructures for hepatic tissue engineering. Acta Biomater 5 453 61... 

Combination of chitosan with other materials to generate hybrid scaffolds is an effective approach for tailoring biomaterials with desired interactions with... 

Khang, G., Kim, S.H., Rhee, J.M., Sha Ban, M., Idrus, R.B.H. Chap, synthetic/natural hybrid scaffold for cartilage and Disc regenerations. In Tateishi, T. (ed.) Biomaterials in Asia in Commemoration of the 1st Asian Biomaterials Congress World Scientific, Singapore (2008)... 

Figure 6.12 Soft X-ray photographs of ectopically formed bone 1, 2, 3, and 4weeks after implantation of coUagen sponges reinforced with the incorporation of PGA fiber, incorporated with PA (a), basic fibroblast growth factor (bFGF) (b), and self-assembled PA nanofibers (hybrid scaffold) (c). Arrows indicate the newly formed bone. The concentration of bFGF used was 50pg.

Hosseinkhani H, Hosseinkhani M, Tian F, Kobayashi H, Tabata Y. Bone regeneration on a collagen sponge self-assembled peptide-amphiphile nanofiber hybrid scaffold. Tissue Eng 2007 13 11-9. 

The biological performance of polyesters can be improved by their association in a blend form with natural polymers or other specific molecules. The obtained blend is submitted to the electrospinning process for production of a hybrid scaffold. 

Besides natural polymers, polyesters have also been associated with different synthetic polymers to produce scaffolds with combined properties. In their study, in order to improve the scaffold hydrophilicity, Shaffie and colleagues produced hybrid scaffolds using PCL and poly(vinyl alcohol) (PVA) via co-electrospinning. PVA is a hydrophilic and also biodegradable and biocompatible polymer. The PCL/PVA scaffolds had a higher hydrophilicity and also supported a greater initial adhesion and proliferation rate of MSC than PCL scaffolds. When they... 

Ekaputra, A.K., Prestwich, G.D., Cool, S.M., and Hutmacher, D.W. (2011) The three-dimensional vascularization of growth factor-releasing hybrid scaffold of poly (epsilon-caprolactone)/collagen fibers and hyaluronic acid hydrogel Biomaterials, 32 (32), 8108-8117. 

Wang, H., Feng, Y, An, B., Zhang, W, Sun, M., Fang, Z. et al (2012) Fabrication of PU/PEGMA crosslinked hybrid scaffolds by in situ UV photopolymerization favoring human endothelial cells... 

M. Prabaharan, et al.. Preparation and characterization of poly(L-lactic acid)-chitosan hybrid scaffolds with drug release capability. Journal of Biomedical Materials Research. Part B, Applied Biomaterials 81 (2) (2007) 427—434. 

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