Glasses bioactive

W. Vogel and co-workers, in T. Yamamuro, L. L. Hench, and J. Wilson, eds.. Handbook of Bioactive Ceramics, Hoi 1, Bioactive Glasses and Glass-Ceramics, CRC Press, Boca Raton, Fla., 1990. 

Alfonso, C. Fenselau, C. Use of bioactive glass shdes for matrix-assisted laser desorption/ionization analysis Apphcation to microorganisms. Anal. Chem. 2003, 75, 694-697. 

Kokubo, T. (1990) Surface chemistry of bioactive glass-ceramics. Journal of Non-Crystalline Solids, 120, 138-151. 

Kokubo et al. [16,17] showed that the hydroxyapatite formation on the surfaces of bioactive materials in the living body can be reproduced even in an acellular protein-free simulated body fluid (SB F) with ion concentrations nearly equal to those of human blood plasma. This indicates that the hydroxyapatite layer is formed through chemical reaction of the bioactive glass with the surrounding body fluids. The formed layer consists of carbonated hydroxyapatite with small crystallites and low crystallinity, which is similar to bone hydroxyapatite. Hence the bioactivity of a material can be evaluated even in vitro by examining the hydroxyapatite formation on its surface in SBF. 

Kokubo, T. (1991) Bioactive glass ceramics Properties and applications. Biomaterials, 12, 155-163. 

Kokubo, T., Ito, S., Huang, Z.T., Hayashi, T., Sakka, S., Kitsugi, T. and Yamamuro, T. (1990) Ca, P-rich layer formed on high-strength bioactive glass-ceramic A-W. Journal of Biomedical Materials Research, 24, 331-343. 

Bioactive glasses are currently used as granulate for bone and dental grafting in small defects, or as powder incorporated into toothpaste. Although silica-based bioactive glasses meant an extraordinary advance in the field of bone tissue regeneration, their application as pieces for medium and large defects is not possible due to their very poor mechanical properties. 

Hench, L.L. and Andersson O. (1993) bioactive Glasses. An Introduction to Bioceramics (eds L.L. Hench and J. Wilson), World Scientific Publishing, Singapore, pp. 41. 

Hench, L.L. and Paschall H.A. (1973) Direct chemical bond of bioactive glass-ceramic materials to bone and muscle. Journal of Biomedical Materials Research Symposium, 4, 25. 

Ordered mesoporous silica have already been studied as carriers for drug delivery [1,2] recently, their use has also been proposed in bone tissue engineering [3,4], in combination with bioactive glass-ceramic scaffolds [5,6]. The kinetics of ibuprofen release in SBF [7] from MCM-41 silica with similar pore diameter has shown puzzling discontinuities [3,6,8] aim of the present work is to assess whether these anomalies may be related to structural changes in the MCM-41 mesoporous spheres under the adopted conditions. 

Fortune 500 corporations, as sponsors of research, 24 385 45S5 bioactive glass, 12 611 40-nucleotide hammerhead ribozyme, 17 619... 

Sol—gel, alumina derived from, 23 76—78 Sol-gel bioactive glasses, 23 82-83 Sol-gel chemistry aerogels, 1 749-753 ceramics processing, 5 642 Sol-gel coatings, 5 665... 

Ostomel TA, Shi QH, Tsung CK, Liang HJ, Stucky GD (2006) Spherical bioactive glass with enhanced rates of hydroxyapatite deposition and hemostatic activity. Small 2 1261-1265. 

L. L. Hench, Bioactive glasses and glass-ceramics. Mater. Sci. Forum 293 (1999) 37-64. 

W. Holand, W. Vogel, K. Nauman, J. Gummel, Interface reactions between machinable bioactive glass-ceramics and bone, J. Biomed. Mater. Res. 19 (1985) 303-312. 

Silva, G. A., Costa, F. J., Coutinho, O. P, Radin, S., Ducheyne, R, Reis, R. L. (2004). Synthesis and evaluation of novel bioactive composite starch/bioactive glass microparticles. J. Biomed. Mater. Res. Part A., 70A 3), 442 49. 

Fig. 18.3. Raman spectral analysis of foetal osteoblast (FOB) differentiation. Unsupervised PCA of FOB cells cultured for 3 days in bioactive glass (BG) conditioned media (triangle) or control media (circle) (a). BG-treated cells formed a distinct cluster separate from control cells after 3 days culture. Least square (LS) analysis (which decomposes the cell spectra into the linear combination of Raman spectra obtained from the pure chemical constituents of the cell, e.g. nucleic acid, proteins, lipids, phospholipids and carbohydrates) of the relative RNA concentration of FOBs cultured for 1, 3 and 14 days in culture media (black) or BG condition media (grey), revealed a significantly reduced relative RNA concentration in FOBs culture in BG-conditioned media (b). FOBs cultured in BG-conditioned media appeared to accelerate FOB differentiation into mature adult osteoblast phenotypes (parallel gene and protein expression experiments confirmed this). Significant difference to control (p <0.05) [38]...

Ducheyne, P., Stimulations of biological function with bioactive glass. MRS Bull. 23 (11), 43-49 (1999). 

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