Soft-tissue engineering

Wang and coworkers first reported the use of these monomers as a novel elastomeric material for potential application in soft tissue engineering in 2002. The molar ratio of glycerol to sebacic acid they used was 1 1. The equimolar amounts of the two monomers were synthesized by polycondensation at 120°C for three days. The reaction scheme is shown in Scheme 8.1. To obtain the elastomers, they first synthesized a prepolymer and then poured an anhydrous 1,3-dioxolane solution of the prepolymer into a mold for curing and shaping under a high vacuum. 

Pego AP, Poot AA, Grijpma DW, and Feijen J. Biodegradable elastomeric scaffolds for soft tissue engineering. J Control Rel, 2003, 87, 69-79. 

A range of functionalized and unfunctionalized self-assembling fibrous structures have been tested for their biocompatibility and ability to provide cells with a favorable micro- and nanoenvironments for soft tissue engineering. In this section, studies that focus on amyloid fibrils, on peptide amphi-philes, on ionic complementary peptides, and on dipeptide structures are reviewed. Hard tissue engineering, composites, and coating are also explored followed by macroscopic structures and networks that can be created from fibrous protein structures. 

Soft tissue engineering and implants, absorbable sutures, wound dressings, drug delivery Cell encapsulation and drug delivery Oligomeric drug carriers, polyelectrolyte complexes for cell encapsulation... 

Baker BM et al (2009) New directions in nanofibrous scaffolds for soft tissue engineering and regeneration. Expert Rev Med Devices 6(5) 515-532... 

Parrag IC, Woodhouse KA (2010) Development of biodegradable polyurethane scaffolds using amino acid and dipeptide-based chain extenders for soft tissue engineering. J Biomater Sci Polym Ed 21(6-7) 843-862... 

Park, S. A., Lee, S. H., Kim, W. Fabrication of hydrogel scaffolds using rapid protot rping for soft tissue engineering. Macromol. Res.. 2011,19, 694-698. 

C. G. Jeong, S.J. HoUister, Mechanical, permeability and degradation properties of 3D designed poly(l,8-octanedioTco-citrate) scaffolds for soft tissue engineering, J. Biomed. Mater. Res. B Appl. Biomater. (2010) 142-149. 

R.M. Day, A.R. Boccaccini, S. Shurey, J.A. Roether, A. Forbes, L.L. Hench, et al.. Assessment of polyglycolic add mesh and bioactive glass for soft-tissue engineering scaffolds. Biomaterials 25 (2004) 5857-5866. 

K. Hemmrich, D. von Heimburg, R. Rendchen, C. Di Bartolo, E. Milella, N. Pallua, Implantation of preadipocyte-loaded hyaluronic acid-based scaffolds into nude mice to evaluate potential for soft tissue engineering. Biomaterials 26 (34) (2005) 7025-7037. 

C. Ji, N. Armabi, A. Khademhosseini, F. Dehghani, Fabrication of porous chitosan scaffolds for soft tissue engineering using dense gas COj, Acta Biomater. 7 (2011) 1653—1664. 

D. von Heimburg, et al.. Preadipocyte-loaded collagen scaffolds with enlarged pore size for improved soft tissue engineering, Int. J. Artif. Organs 26 (2003) 1064-1076. 

H. Tan, Q. Shen, X. Jia, Z. Yuan, D. Xiong, Injectable nanohybrid scaffold for biopharmaceuticals delivery and soft tissue engineering, Macromol. Rapid Commun. 33 (2012) 2015-2022. 

K. Toriyama, et al.. Endogenous adipocyte precursor cells for regenerative soft-tissue engineering, Tissue Eng. 8 (2002) 157-165. 

R. T. Tran, P. Thevenot, Y. Zhang, D. Gyawali, L.P. Tang, J. Yang, Scaffold sheet design strategy fa- soft tissue engineering. Materials 3(2010)1375-1389. 

Volume I Fabrication and Self-Assembly of Nanobiomaterials Volume II Engineering of Nanobiomateriais Voiume III Surface Chemistry of Nanobiomaterials Volume IV Nanobiomaterials in Hard Tissue Engineering Voiume V Nanobiomaterials in Soft Tissue Engineering... 

Leach J B, Bivens K A, Collins C N and Schmidt C E (2004), Development of photocrosslinkahle hyaluronic acid-polyethylene glycol-peptide composite hydrogels for soft tissue engineering , J Biomed Mater Res A, 70, 74-82. 

E.5.2.2.1 The Concept of the Consilient Approach to Soft Tissue Engineering... 

Polymers used as biomaterials can be natural, synthetic or hybrid. With the growing field of regenerative medicine and medical devices, polymers dominate the soft tissue engineering and drug delivery industry and are gradually replacing metals and ceramics in the hard tissue engineering field as well. 

Chen, Q.Z., Liang, S.L., Wang, J., Simon, G.P., 2011. Manipulation of mechanical compliance of elastomeric PGS by incorporation of halloysite nanotubes for soft tissue engineering applications. Journal of the Mechanical Behavior of Biomedical Materials 4 (8), 1805-1818. 

Pa, suggesting the potential application of these polymers in soft tissue engineering or drug delivery applications. 

Soliman S, Pagliari S, Rinaldi A, Forte G, Fiaccavento R, Pagliari F, Franzese 0, Minieri M, Nardo P, Licoccia S and Traversa E (2010) Multiscale three-dimensional scaffolds for soft tissue engineering via multimodal electrospinning, Acta Biomater 6 1227-1237. 

Wang F, et al. Synthesis, characterization and surface modification of low moduli poly(ether carbonate urethane)ureas for soft tissue engineering. Acta Biomater 2009 5(8) 2901-12. 

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