Bioactive compounds isolation

Salvinorin A is a bioactive compound isolable from /S. divinorum/, is not at all clear that it s responsible for the plant s more interesting effects, however. I ll admit that I haven t read the... 

This review describes the chemistry of the bioactive compounds isolated from the sea hares belonging to two genera Aplysia and Dolabella Yamada, K. Kigoshi, H. Bull. Chem. Soc. Jpn., 1997, 70, 1479-1489. 

This review describes bioactive compounds isolated from marine algae and invertebrates with an emphasis on then-uniqueness. Because of limited space, metabolites from bacteria, cyanobacteria, and fungi cannot be included, although some from cyanobacterial and endosymbiotic bacterial origins are described (some reviews on metabolites of marine bacteria, cyanobacteria, and fungi are provided in the Further Reading section). Structures and bioactivities are described for compounds that represent natural product classes, but steroids and carotenoids are not included. 

The fermentation products of Monascus, especially those produced by solid-state fermentation of rice, have been used as food and health remedies for over 1000 years in China. Monascus rice products (MRPs) are currently being used as health foods in the United States and many Asian countries such as Japan, Taiwan, China, Korea, Thailand, the Philippines, and Indonesia. Many studies have shown that Monascus spp. produce commercially viable metabolites, including food colorants, cholesterol-lowering agents, and antibiotics. The most important bioactive compound isolated from Monascus is monacolin K, which is identical to the potent cholesterol-lowering, antiatherosclerotic drug lovastatin, a 3-hydroxy-3-methylglutaryl... 

The bioactive compounds isolated from plants and responsible for the medicinal properties mentioned here and different health -improving effects are named secondary metabolites [9]. It is generally believe that they do not play an essential role in plant growth and development. However, they participate in plant adaptation responses and defense functions. It is well known that these compounds play an important role in their survival in the ecosystem because they are involved in the resistance against pests, diseases and other functions such as attraction of pollinators and interactions with organisms of their enviromnent [1, 6, 9]. 

A series of cytotoxic kaurene and B-secokaurene diterpenoids from Rhabdosia species (Lamiaceae) have potential antitumor activity. Oridonin (87), lasiokaurin, enmein (43), and nodosin (88) are some of the early bioactive compounds isolated from members of this genus (Alcaraz and Rios, 1991). 

Kupfer R, Swansrai L, Chow S, Staub RE, Zhang YL, Cohen L Christians U (2008) Oxidative in vitro metabolism of liquiritigenin, a bioactive compound isolated from the Chinese herbal selective estrogen p-receptor agonist MFIOI. Dmg Metab Dispos 36 2261... 

Phenols are considered important bioactive compounds isolated from plants because of their potential role in human health management. Phenolic structure consists of an aromatic ring with attached hydroxyl groups. Based on structural differences, phenols can be classified into groups and components. The broad classifications include phenolic acids, stilbenes, lignans, and fiavonoids [4]. 

This review will focus on the recent data reported on the extraction, characterization and biological activities of bioactive compounds isolated from fraits of selected Cornus plants in order to imderstand the high nutritional value of these fruits and their possible use as somce of bioactive compoimds for developing new pharmacological products. 

Figure 1. Bioactive compounds isolated from Nigerian medicinal plants.

Often, planar chromatography is used as a preparative step for the isolation of single components or classes of components for further chromatographic separation or spectroscopic elucidation. Many planar chromatographic methods have been developed for the analysis of food products, bioactive compounds from plant materials, and essential oils. 

Degenhardt, P. and Winterhalter, E., HSCCC a powerful tool for the preparative isolation of bioactive compounds, in Biologically-Active Phytochemicals in Food Analysis, Metabolism, Bioavailability and Function, Pfannhauser, W. et ah, Eds., Royal Society of Chemistry, Cambridge, 2001, 143. 

The consumption of dairy products plays a significant role in providing high-quality protein, vitamins, minerals, and other bioactive compounds to the American diet. Dairy products are consumed fresh in the United States in the form of fluid milk, cheese, yogurt, butter, and ice cream. Dried and condensed products such as nonfat dried milk, whey, whey protein concentrates, and isolates are also produced which are used as ingredients to boost the nutritional and functional properties of a host of other food... 

Spore germination and protonemal growth and morphogenesis are therefore, useful systems to test in vitro, with good reproducibility, potential allelochemicals both through direct co-existence test in vitro or using the described bioassays to monitor/guide isolation, purification, characterization of chemical structure of bioactive compounds. 

In contrast, a number of alkene epoxides (10.3) are chemically quite stable, i.e., intrinsically less reactive than arene oxides. Examples of epoxide metabolites that have proven to be stable enough to be isolated in the absence of degrading enzymes include 1,2-epoxyoctane (10.4), 1,2-epoxycyclohex-ane (10.5), 1-phenyl-1,2-epoxy ethane (styrene oxide, 10.6), and cis- 1,2-diphenyl-1,2-epoxyethane (cfv-stilbene oxide, 10.7) [12], The same is true of alclofenac epoxide (10.8), hexobarbital epoxide (10.9), and a few other epoxides of bioactive compounds. 

As part of a screening program for bioactive compounds from endosym-biontic microorganisms, Zeeck et al. successfully isolated a group of new, structurally related phenazine antibiotics, the so called endophenazines A (74), B (75), C (76), and D (77) from the arthropod-associated endosymbiont Strepto-... 

Jebakumar Solomon RD, Subramaniam K, Jayaraj V. (2005) Isolation, identification and study of antimicrobial property of a bioactive compound in an Indian medicinal plant, Acalypha indica (Indian-Nettle). World J Microb Biotech 21 1231-1236. 

Medicinal chemistry of bioactive natural products spans a wide range of fields, including isolation and characterization of bioactive compounds from natural sources, structure modification for optimization of their... 

Tringali, Corrado, ed. Bioactive Compounds from Natural Sources Isolation, Characterisation and Biological Properties. London Taylor S Francis, 2001. 

Within the operationally defined marine bacteria , i.e., bacteria isolated from marine samples on marine media, bioactive compounds have been reported from Pseudoalteromonas, Cytophaga, Alteromonas, Micrococcus, Bacillus, Acinetobacter, Agrobacterium and Pseudomonas or from unidentified bacteria (Fig. 2). 

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