Bioactive natural products

C. Ireland, D. Roll, T. Molinski, T. MeKee, M. Zabriske and J. Swersey, in Biomedical Importance of Marine Organisms, ed. D. G. Fautin, California Aeadeiny of Seienees, San Franeiseo, 1988, p. 41. C. Ireland, B. Copp, M. Foster, L. MeDonald, D. Radisky and C. Swersey, in Marine Biotechnology, vol. 1, Pharmaceutical and Bioactive Natural Products, ed. D. Attaway and O. Zaborsky, Plenum Press, New York, 1993, eh. 1, p. 1. [Pg.62]

The Pictet-Spengler reaction is one of the key methods for construction of the isoquinoline skeleton, an important heterocyclic motif found in numerous bioactive natural products. This reaction involves the condensation of a P-arylethyl amine 1 with an aldehyde, ketone, or 1,2-dicarbonyl compound 2 to give the corresponding tetrahydroisoquinoline 3. These reactions are generally catalyzed by protic or Lewis acids, although numerous thermally-mediated examples are found in the literature. Aromatic compounds containing electron-donating substituents are the most reactive substrates for this reaction. [Pg.469]

Indoles are designated as privileged structures in medicinal chemistry because they are important constituents of bioactive natural products and... [Pg.104]

Labadie R. Immunomodulatory compounds Chapter in Bioactive Natural Products CRC... [Pg.686]

Over the years, intensive studies in medicinal chemistry with regard to the structure-activity relationships of compounds being used in clinical praxis have revealed the exceptional position of heterocycles. Moreover, a multitude of bioactive natural products contain a heteroatom. Therefore, the development of reliable and efficient... [Pg.26]

The Cacchi group [85] developed a Pd-catalyzed domino process between o-alky-nyltrifluoroacetanilides as 6-157 and aryl or alkenyl halides, which leads to substituted pyrroles within an indole system. This scheme was successfully applied to the preparation of indolo[2,3-a]carbazoles as 6-158 using N-benzyl-3,4-dibro-momaleimide (Scheme 6/1.42). The indolocarbazole is found in several bioactive natural products as arcyriaflavin A and the cytotoxic rebeccamycin. [Pg.385]

The readily available, nonracemic indoloquinolizidine template 471 has been studied as a substrate for the construction of frameworks related to bioactive natural products. The lithiated dithiolane 472 served a dual role in its reaction with 471, both as a nucleophile giving the non-isolated intermediate 473, and, in the same pot, as an electrophile during the quench process. This reaction afforded compound 474 as a single diastereomer <2006TL1961>. [Pg.69]

Natural products continue to demonstrate their utility both as therapeutics and as molecular probes for the discovery and mechanistic deconvolution of various cellular processes. However, this utility is dampened by the inherent difficulties involved in isolating and characterizing new bioactive natural products, in... [Pg.333]

Gerwick WH, Bernart MW (1992) Eicosanoids and related compounds from marine algae. In Attaway DH, Zaborsky OR (eds) Marine biotechnology, vol I Pharmaceutical and bioactive natural products. Plenum, New York, p 101... [Pg.180]

Tan LT (2007) Bioactive natural products from marine cyanobacteria for drug discovery. Phytochem 68 954-979... [Pg.25]

The synthetic usefulness of reactions of lithiated methoxyallene 42 with suitable electrophiles was demonstrated by several syntheses of bioactive natural products or substructures thereof [52-58]. An interesting application was described by Fall et al. [52] after addition of alkyl iodide 55 to lithiated methoxyallene 42, deprotonation by tert-butyllithium and addition of carbon dioxide occurred at the terminal y-carbon and thus provided butenolide 57 after acidic workup. Desilylation of this intermediate with TBAF finally gave bicyclic oxepane derivative 58 in good overall yield (Scheme 8.14). [Pg.434]

Novel Bioactive Natural Products from Marine and Terrestrial Sources... [Pg.56]

Microbial natural product chemistiy has generated a number of bioactive natural products. For instance cyclosporine A FK506 and rapamycin are used as immunosuppressants [16]. Other examples of microbial metabolites, having potential biomedical application include antihyperlipidemics, lovastatin and guggulsterone [17, 18]. The crude extracts of Mucor plumbeus exhibited acetylcholinesterase (AChE) enzyme inhibition activity. Our detailed chromatographic work on this crude extract resulted in the isolation of mucoralactone A (11), a novel steroid containing a lactone moeity incorporated in its structure. [Pg.60]

We have been investigating the feasibility of using metathesis to prepare heterocy-elie eompounds such as quinolines and indoles [12] (Scheme 10.5) and its application to the synthesis of bioactive natural products [13],... [Pg.121]

BIOACTIVE NATURAL PRODUCTS Opportunities and Chaiienges in Medicinal Chemistry... [Pg.675]

All those who are working globally with bioactive natural products for the cause of human... [Pg.676]

Medicinal chemistry of bioactive natural products spans a wide range of fields, including isolation and characterization of bioactive compounds from natural sources, structure modification for optimization of their... [Pg.680]

Pereda-Miranda R (1995) Bioactive Natural Products from Traditionally Used Mexican Plants. In Amason JT, Mata R, Romeo JT (eds) Phytochemistry of Medicinal Plants. Plenum... [Pg.154]

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