Binding multiple

Blanpain C, Migeotte I, Lee B, et al. CCR5 binds multiple CC-chemokines MCP-3 acts as a natural antagonist. Blood 1999 94 1899-1905. 

Chemokines exhibit complex ligand-receptor relationships. Often, individual chemokines can bind productively to more than one receptor, and many chemokine receptors can signal in response to more than one chemokine. Usually, these chemokine receptors bind multiple chemokines within the same subfamily. The best documented example of chemokine receptor promiscuity across subfamilies involves CXCR3 binding to CCL21. 

Hirbec, H., Perestenko, O., Nishimune, A., Meyer, G., Nakanishi, S., Henley, J. M., and Dev, K. K. (2002) The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs. J. Biol. Chem. 277,15221-15224. 

Shrink wrap is a film that is applied loosely around products, then sealed and shrunk by heating to take the shape of the contained products. It can be used to bind multiple packages, or to secure an entire pallet of packages, to bundle magazines and papers, to protect and display albums, CDs and so on. It is usually made of LLDPE, LDPE or polypropylene. 

Iron(n) is known to decompose hydrogen and dialkyl peroxides to free radicals by reductive cleavage of the 0—0 bond and early investigations established the parasite s sensitivity to these species. When treated with radiolabelled C-artemisinin, the hemin-hemozoin fraction of the lysed malaria-infected erythrocytes was shown to contain a radiolabel, though the mechanism of incorporation is not clear. Meshnick and coworkers demonstrated that uninfected cells did not contain radiolabelled proteins whereas six radiolabelled proteins were isolated from cells infected with the Plasmodium falciparum (P. falciparum) strain of the parasite. It was suspected that one of the alkylated proteins was the Histidine Rich Protein (HRP) that was known to bind multiple heme monomers and therefore thought to be instrumental to the parasite s detoxification process. Moreover, iron chelators were found to inhibit the lethal effects of peroxides on the parasite. ... 

Olosz F, Malek TR. 2002. Structural basis for binding multiple ligands by the common cytokine receptor gamma-chain. J Biol Chem. 277 12047-12055. 

Matsumura et al. (147) identified a novel enhancer module, CLEM4, far upstream (about 11 kb) in the human CYP3A4 gene. CLEM4 binds multiple transcription factors, some of them liver-specific such as HNF-4. 

Because they are easily accessible, glycans displayed on the surface of mammalian cells provide enormous opportunities to bind to many microbial pathogens, ranging from viruses to molecular toxins and from pathogenic bacteria to parasites. In multivalent binding, multiple interactions between ligands and various receptors are common (Fig. 16.1). One representative example is ricin—a versatile and durable A-B-type toxin—in which one of the protein chains (the B chain) is a lectin that interacts and binds terminal galactose (Gal) on the surface of eukaryotic cells with multivalent interactions to facilitate entry of the other peptide chain (the A chain) into the cell to cause cellular death via the catalytic... 

Gong, J.-H., Uguccioni, M., Dewald, B Baggiolini, M., and Clark-Lewis, I. (1996) RANTES and MCP-3 antagonists bind multiple chemokine receptors. J. Biol. Chem. 271,10,521. 

RANTES and MCP-3 antagonists bind multiple chemokine receptors. J. Biol. Chem. 271,10,521-10,527. 

Dysbindin-1 may play both peripheral and central roles in the interaction of BLOC-1 with AP-3. The peripheral role would be stabilization of BLOC-1 (see Section 2.2.6.4.1 and Figure 2.2-19). The central role would be enabling the two complexes to bind. As illustrated in Figure 2.2-6, dysbindin-1 s CCD can bind multiple BLOC-1 components (Nazarian et al., 2006), while the YXXO motif in its DD can bind the t subunit of AP-3 (Taneichi-Kuroda et al., 2009), specifically the tA isoform found in both neuronal and non-neuronal cells. The binding of AP-3 i subunits to cargo with the YXXO motif is well known (Bonifacino and Traub, 2003). There is thus reason to suspect that dysbindin-1 acts as an adaptor for interactions of BLOC-1 with AP-3 and in that manner influence intracellular transport. 

Following cannabinoid binding, multiple signaling pathways can be activated Gij0jS-protein mediated modulation of adenylate cyclase and cAMP levels Ca2+ and K+ ion channel activation or activation of different intracellular enzymes/effectors (i.e., kinases, ceramide) in a non-G-protein dependent manner (Childers et al., 1993 Felder et al., 1995 Mackie et al., 1995 Prather et al., 2000 Sanchez et al., 2001). 

In addition to chemokines, viruses also ex- ss chemokine receptors. All of them bind [Multiple chemokine ligands but differ in their becificity as well as in the signal transduction... 

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