Antagonists natural

Low K, Crestani F, Keist R, et al Molecular and neuronal substrate for the selective attenuation of anxiety. Science 290 131-134, 2000 Luddens H, Pritchett DB, Kohler M, et al Cerebellar GABAA receptor selective for a behavioural alcohol antagonist. Nature 346 648—651, 1990 LupoloverY, Safran AB, Desangles D, etal Evaluation ofvisual function in healthy subjects after administration of Ro 15-1788. Eur J Clin Pharmacol 27 505-507, 1984 Maher JF, Schreiner GE, Westervelt FB Jr Acute glutethimide intoxication 1. clinical experience (twenty-two patients) compared to acute barbiturate intoxication (sixty-three patients). Am J Med 33 70-82, 1962 Marks J The Benzodiazepines Use, Overuse, Misuse, Abuse. Baltimore, MD, University Park Press, 1978... 

P Hess, JB Lansman, RW Tsien. (1984). Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists. Nature 311 538-544. 

Luddens, H., Pritchett, D.B., Kohler, M., Killisch, L, Keinanen, K., Monyer, H., Sprengel, R., and Seeburg, P.H. (1990) Cerebellar GABAj receptor selective for a behavioural alcohol antagonist. Nature 346 648-651. 

Turski L., Bressler K., Rettig K.-J., Loschmann P.-A., and Wachtel H. (1991). Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists. Nature 349 414 117. 

NMDA antagonist Nature Effect on ischemia Reference... 

Carlsson A, Lindqvist M, Magnusson T (1957) 3,4-dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists. Nature 750 1200. 

Gattone VH 2nd, Wang X, Harris PC, Torres VE. Inhibition of renal cystic disease development and progres- 399. sion by a vasopressin V2 receptor antagonist. Nature Med 2003 9 1323-6. 

Carlsson A, Lindquist M, Magnusson T (1957) 3-4 Dihydroxyphenylalanine and 5-hydroxy-tryptophanas reserpine antagonists. Nature 180 1200-12001 Castellani RJ, Nunomura A, Lee HG, Perry G, Smith MA (2008) Phosphorylated tau toxic, protective, or none of the above. J Alzheimers Dis 14(4) 377-383 Cleary JP, Walsh DM, Hofmeister JJ, Shankar GM, Kuskowski MA, Selkoe DJ, Ashe KH (2005) Natural oligomers of the amyloid-beta protein specifictilly dismpt cognitive function. Nat Neurosci 8(l) 79-84... 

Bowery, N.G., Collins, J.F. and Hill, R.G., 1976 Bicyclic phosphorus esters that are potent convulsants and GABA antagonists. Nature 261 601-603. 

Eisenberg, S.P., Evans, R.J., Arend, W.P. etal. (1990). Primary structure and functional expression from complimentary DNA of a human interleukin-1 receptor antagonist. Nature 343, 343-346. 

Clozel, M., Breu, V, Burri, K., Cassal,J.-M., Fischli, W., Gray, G.A., Hirth, G., Loeffler, B.-M., Mueller, M., Neidhart, W. Ramuz, H. (1993) Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist. Nature (Load) 365,759-761. 

Beinhrom, M., Lee, Y.-M., McBride, E.W., Quinn, S.M. and Kopin, A.S. (1993) A single amino acid of the cholecystokinin-B 1 gastrin receptor determines specificity for non-peptide antagonists. Nature 362 348-351. 

Arenzana-Seisdedos, F., Virelizier, J. L., Rousset, D., Clark-Lewis, I., Loetscher, P., Moser, B., and Baggiolini, M. (1996) HIV blocked by chemokine antagonist. Nature 383, 400-400. 

Kuhar, M. J., and Yamamura, H. L, 1975, Light autoradiographic localization of cholinergic muscarinic receptors in rat brain by specific binding of a potent antagonist. Nature (London) 253 560-561. 

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