Binding diversity

Adsorbent powders are nonabsorbable materials with a large surface area. These bind diverse substances, including toxins, permitting them to be inactivated and eliminated. Medicinal charcoal possesses a particularly large surface because of the preserved cell structures. The recommended effective antidiarrheal dose is in the range of 4-8 g. Other adsorbents are kaolin (hydrated aluminum silicate) and chalk. 

The immunological origins of 1E9 have been traced to a family of highly restricted germline antibodies that bind diverse hydrophobic ligands [30]. A precise fit to the... 

Proteins consist mainly of C, H, N, O, S, Se, and can bind diverse metal ions in modified side-chains that often carry phosphate residues. These modified residues often lead to changes in structure and function. 

Protein domains are conserved regions of a limited number of amino acids that can bind diverse partner molecules to form structures of a higher complexity. The domains have a heterogeneous internal organization that consist of amino acid interactions and comprise multiple functionally distinct sectors or subdivisions. The sectors are regions of proteins that are distinct from the hierarchy of primary, secondary, tertiary, and quaternary structures. 

Lin CH et al (2001) A small domain of CBP/p300 binds diverse proteins solution structure and functional studies. Mol Cell 8(3) 581-590... 

The sHsps are a diverse family of proteins, which are related by possession of a common, defined a-crystallin structural domain. While virtually all of these proteins share the capacity to act as chaperones by binding non-native proteins in an ATP-independent manner, evolutionary arguments and biochemical data indicate that they can interact with many different proteins to influence a potentially wide range of functions in different cells and organisms. In this regard, they are similar to other chaperones which, by the ability to bind diverse substrates, act to protect and/or to regulate multiple cellular processes. 

Kiiwacki, R.W., Hengst, L., Tennant, L., et al. (1996) Structural studies of p21Wafl/Cipl/Sdil in the free and Cdk2-lx>und state Conformational disorder mediates binding diversity. Proc Natl Acad Sci USA, 93 (21), 11504-11509. 

NICA isotherm for competitive binding. Diverse electrostatic models are considered, mainly based on one out of two concepts the impermeable sphere model (similar to a mineral particle) or the Dorman phase model, where a certain volume is assumed to be in Donnan equilibrium with the bulk. Considering these contributions, several models are proposed in the end showing similar fitting quality to titration curves because these curves have poor sensitivity to the many adjustable parameters additional, independent data are needed to improve modeling of cation binding to HSs. 

In addition to halopeiidol, the putative neuroleptics, limcazole (311), lemoxipiide (312), and gevotioline (313) bind to (7-ieceptois as does the dopamine uptake blocker, GBR 12909 (314) and two ligands active at the NMDA receptor, ifenprodil (315) and CNS 1102 (316). NPC 16377, (317) is a selective (7-teceptor ligand. MAO inhibitors and antidepressants also bind to (7-teceptors. Some evidence indicates that (7-teceptors in the brain are in fact a form of cytochrome which may account for the diversity of ligands interacting with (7-sites. 

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