Binding site diversity

Scheme 14.1 Fold similarity and binding site diversity and their implications for combinatorial library development.

Sandelin, A., and Wasserman, W. W. (2004) Constrained binding site diversity within families of transcription factors enhances pattern discovery bioinformatics. J. Mol. Biol. 338, 207-215. 

SYNTHESIS AND CHARACTERIZATION OF HYDROGEN-BONDED ASSEMBLIES TOWARD THE GENERATION OF BINDING SITE DIVERSITY... 

Functionalized Hydrogen-Bonded Assemblies. Towards the Generation of Binding Site Diversity... 

D.N. Reinhoudt, P. Timmerman, F. Cardullo and M. Crego-Calama 181 Synthesis and Characterization of Hydrogen-bonded Assemblies Toward the Generation of Binding Site Diversity... 

FIGURE 7.3 Diversity of structures that interact with the (a) HIV reverse transcriptase inhibitor binding site [8] and (b) the CCR5 receptor mediating HIV-1 fusion [9],... 

C2 domains (phosphokinase C conserved 2 domains) mediate membrane targeting of diverse peripheral proteins. A C2 domain consists of approximately 130 residues and was first discovered as the Ca2+-binding site in conventional phosphokinase Cs. 

The ribosome is the cellular target of a large and chemically diverse group of antibiotics. The antibiotic binding sites are clustered at functional centers of the ribosome and the majority are composed exclusively of RNA. The drugs interfere with the positioning and movement of substrates, products and ribosomal components that are essential for protein synthesis. 

Our results suggest that the numerically predominant 153 nM 3H-(+)SKF-10,047 site represents the PCP opioid receptor. The much less abundant haloperidol - sensitive 3.6 nM 3H-SKF-10,047 binding site that we have described appears to represent the same entity as a class of sites reported by several other groups utilizing diverse strategies, including use of H-SKF-10,047 in the presence of etorphine (Su 1982) 3H-ethylketoSycl azocine (EKC) in the presence of excess naloxone (Tam 1983) 3H-(+)SKF-10,047 or (+)3H-... 

---