Benzyl chloroformate chloride

Nearly all of the benzyl chloride [100-44-7], henzal chloride [98-87-3], and hen zotrichl oride /P< -(97-i manufactured is converted to other chemical intermediates or products by reactions involving the chlorine substituents of the side chain. Each of the compounds has a single primary use that consumes a large portion of the compound produced. Benzyl chloride is utilized in the manufacture of benzyl butyl phthalate, a vinyl resin plasticizer benzal chloride is hydrolyzed to benzaldehyde hen zotrichl oride is converted to benzoyl chloride. Benzyl chloride is also hydrolyzed to benzyl alcohol, which is used in the photographic industry, in perfumes (as esters), and in peptide synthesis by conversion to benzyl chloroformate [501-53-1] (see Benzyl ALCOHOL AND p-PHENETHYL ALCOHOL CARBONIC AND CARBONOCm ORIDIC ESTERS). 

Benzoyl chloride Benzyl bromide Benzyl chloride Benzyl chloroformate... 

Ammonium thiocyanate Anisoyl chloride Benzhydry bromide (diphenyl methyl bromide) Benzoyl chloride Benzyl bromide Benzyl chloride Benzyl chloroformate (benzyl chlorocarbonate) Butyl acid phosphate Chloracetyl chloride... 

Benzyl alcohol, 23, 14 Benzylamini, a-METHYL-, 23, 68 Benzyl carbamate, 23,14 Benzyl chloride, 21, 99 Benzyl chloroformate, 23,13 Benzyl cyanide, 23, 71... 

Acetyl bromide, 0728 f Acetyl chloride, 0735 f Aciyloyl chloride, 1093 Azidocarbonyl fluoride, 0339 Benzenesulfinyl chloride, 2234 Benzenesulfonyl chloride, 2235 Benzoyl chloride, 2675 Benzyl chloroformate, 2931... 

BENZYL CHLOROFORMATE Chloroformic Acid, Benzylcarbonyl Chloride, Benzyl Chlorocarbonate Corrosive Material, I 3 1 3... 

The Z-protected derivative, again prepared by standard methods using benzyl chloroformate,t208 may serve in the case of racemic pipecolic acid for resolution into the pure enantiomers by fractional crystallization with L-tyrosine hydrazide/208 Acylation with N-protected pipecolic acid or of pipecolyl peptides is performed by standard procedures via the active ester methods, e.g. A-hydroxysuccinimide ester/121 by the mixed anhydride method, e.g. with isobutyl chloro-formate 95-114 or pivalic acid chloride/121 as well as by DCC/HOBt/118 In the synthesis on solid support, longer coupling times are required when compared to N-protected proline.1[235 ... 

Clay den et al. [115] have reported the synthesis of spirocyclic p-lactams 176 (Scheme 41) by exo-cyclization of lithiated pyridine and quinoline carboxamides. The reaction of isonicotinamide or chlorinated isonicotinamide 175 with LDA at -40°C with addition of methyl chloroformate led to the formation of spirocyclic p-lactams 176 in good yields. Benzyl chloroformate, benzoyl chloride, methyl triflate can also be used as the effective acylating agents. In these type of reactions, lithiation of /V-benzyl pyridine and quinoline carboxamides to nitrogen provided... 

Presumably, reaction of chloride ion with benzyl chloroformate formed benzyl chloride. 

Ammonium perchlorate, Impurities, 3998 Azidoacetic acid, 0770 f Aziridine, Acids, 0859 Benzoyl azide, 2694 Benzyl chloroformate, 2926 1,2-Bis(difluoroamino)-/V-nitroethylamine, 0799 Bromine trioxide, 0259 2-Butanone oxime, 1649 2-Butyne-l,4-diol, 1523 Butyraldehyde oxime, 1650 Carbon, Unsaturated oils, 0297 Chlorine, Carbon disulfide, 4041 f l-Chloro-2,3-epoxypropane, Contaminants, 1158 Cyanogen chloride, 0322 Diethyl phosphorochloridate, 1675 f 1,1-Difluoroethylene, 0696... 

S-(+)-3-Chloro-l,2-propanediol Methanesulfonyl chloride Potassium t-butoxide 4-Nitrobenzenesulfonyl chloride Hydrochloric acid Diisopropylethylamine Benzyl chloroformate... 

SYNS BENZYLCARBONYL CHLORIDE BENZYL CHLOROCARBONATE pOT) BENZYL CHLOROFORMATE pop BENZYLOXYCARBONYL CHLORIDE BZCF CARBOBENZOXY CHLORIDE CARBOBENZYLOXY CHLORIDE CHLOROFORMIC ACID BENZYL ESTER... 

Poly (methyl acrylate) was reacted with EDA at — 78 °C, and the corresponding polyeno-late was reacted with electropiles such as benzaldehyde, benzyl chloroformate, 2-naphthoyl chloride and iodomethane (Scheme 4) . The substitution yield did not, however, exceed 34%, which is much lower than the yield reported in case of low molecular weight compounds. Steric factors are a reasonable explanation for this observation. 

Chiral Imidazolidinones with Other Substitution Patterns. The intermediate imidazolidinone (2) can also be N-acylated by Benzoyl Chloride or Benzyl Chloroformate, and other substituents on the acetal center and/or on the N(3) nitrogen can be present, depending upon the aldehyde used for the imine formation and upon the glycine amide employed at the beginning of the synthesis. Chiral substituents, such as the 1-phenylethyl group may be placed on N(3), and the imidazolidinone may be derived from a dipeptide. Some examples are collected for (15), with references, in Table fijesg different derivatives... 

---