Benzyl pyridine

Benzyl pyridine p-Dimethylaminoethyl chloride Potassium amide Maleic acid... 

CAS 101-82-6 EINECS/ELINCS 202-979-1 Synonyms 2-(Phenylmethyl) pyridine Pyridine, 2-benzyl- Pyridine, 2-(phenylmethyl)-... 

Benzylpiperidine 2-Benzyl pyridine 4-Biphenylcarboxaldehyde Bismuth nitrate Bromine... 

Direct cycloauration is particularly effective when six-membered C,N metalla-cycles are formed, as in the case of the 2-benzyl-pyridine complexes 7-9 [55], the 2-anilinopyridine complexes 10-13 [56,57], and the 2-phenoxy- and 2-(phe-nylsulfanyl)-pyridine complexes 14-15 [57] (Figure 4.5). In most cases, adducts (HL)AuCl3, which are formed when operating under mild conditions, are... 

The mixture is refluxed with stirring for ten hours, cooled and filtered. The filtrate is extracted three timas with 200 cc portions of 6 N acetic acid. The aqueous acetic acid solution is then made strongly basic with 10% sodium hydroxide solution, and extracted three times with 200 cc portions of ether. The ether extract is dried with anhydrous sodium sulfate, stirred with 5 g of activated carbon and filtered to provide 2-[p-chloro-a(2-di-methylaminoethoxylbenzyll pyridine in solution. Addition of a solution of 116 g (1 mol) of maleic acid in 1,500 cc of ether gives 323 g (79%) of solid which, on recrystallization from ethyl acetate, gives white solid 2-[p-chloro-a(2-dimethvlaminoethoxv)benzyl] pyridine maleate melting at 117° to 119°C. 

Chemical Name d-2-[4-bromo-a-(2-dimethYlaminoethvl)benzYl] pyridine maleate Common Name —... 

In the former Soviet Union much use is made of industrial by-products to prepare acid inhibitors. The PB class is obtained by treating technical butyraldehyde with ammonia and polymerising the resulting aldehyde-ammonia. PB-5, for example, with O-Ol-O-15% of an arsenic salt is used in 20-25% HCl. A mixture of urotropine (hexamethyleneimine, hexamine) with potassium iodide, a regulator and a foaming agent is the ChM inhibitor. BA-6 is prepared from the condensation product of hexamine with aniline. A more recent development is the Katapin series which consists of /7-alkyl benzyl pyridine chlorides Katapin A, for example, is the /7-dodecyl compound. 

Other sensitive tests for cyanide may he used, e.g. the pink colour produced with a mixture of chloramlne-T, barbiturio acid solution and y-benzyl pyridine in acetone. 

The simplest system found to undergo a coralyne-type cyclization is that of the 2-(3,4-dialkoxybenzyl)pyridines (193 Scheme 103). Best results (74% yield) were obtained when R1 = Et and R = Me, and the worst (25% yield) was with 2-(3,4-methylenedioxy-benzyl)pyridine (193 R1 = —CH2—) which gave the expected salt (194) (60JOC293). The latter result is of interest in that it was shown by Awe et al. (60AF936) that a l-(3,4-methylenedioxybenzyl)isoquinoline failed to cyclize under much the same conditions. 

Pharmaceuticals. A wide variety of pyridine compounds, with varying, and often multiple, drug action are used commercially. A few examples are given. A number of antihistamines contain the pyridine moiety in their structure, as exemplified by chlorpheniramine maleate (2-[p-chloro-a-(2-dunethylaminoethyl)benzyl] pyridine acid maleate) doxylamine succinate (2-[cM2-dimethylamino)ethoxy- -methylbenzyl]-pyridine add succinate) and pyrilamine maleate (2-(2-dimethyl-aminoethyl-2-p-methoxybenzyl) aminopyndine acid maleate). These products are synthesized, e.g., from... 

Benzylpyridine (called 2-, 3- or 4-Benzyl-pyridin in Get), CJ2HnN mw 169.22, N 8.28%. This compd exists in 3 isomeric forms ... 

Clay den et al. [115] have reported the synthesis of spirocyclic p-lactams 176 (Scheme 41) by exo-cyclization of lithiated pyridine and quinoline carboxamides. The reaction of isonicotinamide or chlorinated isonicotinamide 175 with LDA at -40°C with addition of methyl chloroformate led to the formation of spirocyclic p-lactams 176 in good yields. Benzyl chloroformate, benzoyl chloride, methyl triflate can also be used as the effective acylating agents. In these type of reactions, lithiation of /V-benzyl pyridine and quinoline carboxamides to nitrogen provided... 

Chemical Name d-2-[p-Chloro-a-(2-dimethylaminoethyl)benzyl]pyridine maleate... 

A solution of 3,4-dimethylpyridine was added to a methyliodid. Then to the resulting solution containing 1,3,4-trimethylpyridinium iodide the 4-methoxybenzylmagnesium chloride was added. After reaction process the l,3,4-trimethyl-2-(4-methoxy-benzyl)-pyridine was obtained. 

To the solution of l,3,4-trimethyl-2-(4-methoxy-benzyl)-pyridine was reduced by hydrogen over 10% palladium-on-charcoal, and when reduction was complete, the catalyst was removed by filtration and the filtrate taken to dryness. The residue was recrystallized to give 2-(4-methoxybenzyl)-l,3,4-trimethyl-1,2,5,6-tetrahydropyridine. 

Cr3+ can also be integrated into the structures of layered double hydroxides. A mixed oxide, prepared by calcination of ZnCr-LDH-CCh, was used in combination with t-BuOOH for the ketonization of alkyl and of benzyl pyridines and for the oxidation of benzyl amines to give Schiff bases (67,68). In contrast to MgAl-LDHs, for example, these materials display hardly any basicity so that base-catalyzed side reactions such as aldol condensations are avoided. 

SYNS p-AMINOSALICYLSAEURES SALZ (GERMAN) 2-(a-(2-DIMETHYLAMINOETHYL)BENZYL)PYRIDINE 2-(3-DIMETHYLAMINO-l-PHENYLPROPYL)PYRIDINE N,N-DIMETHYL-3-PHENYL-3-(2-PYRIDYL)PROPYL-AMINE NCI-C60695 1-PHENYL-1-(2-PYRIDYL)-3-DI-METHYLAMINOPROPANE 3-PHENYL-3-(2-PYRIDYL)-N.N-DIMETHYLPROPYLAMINE... 

A-/7-methoxybenzyl)pyridin-4-yl]methyl-1,4,8,11-tetraazacyclo-tetradecane or 6-[(A-benzyl)pyridin-4-yl]methyl-1,4,8,11 -tetraazacy-clotetradecane... 

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