Anisoyl chloride

Ammonium thiocyanate Anisoyl chloride Benzhydryl bromide... 

Chemical Designations - Synonyms p-Anisoyl Chloride Chemical Formula p-CHjOC HjCOCl. Observable Characteristics - Physical State (as normally shipped) Liquid Color. Yellow brown Odor. Sharp, penetrating. 

Reaction of the potassium salt of salicylaldehyde with chlo-roacetone affords first the corresponding phenolic ether aldol cyclization of the aldehyde with the ketonic side chain affords the benzofuran (1). Reduction of the carbonyl group by means of the Wolf-Kischner reaction affords 2-ethyl-benzofuran. Friedel-Crafts acylation with anisoyl chloride proceeds on the remaining unsubstituted position on the furan ring (2). The methyl ether is then cleaved by means of pyridine hydrochloride (3). lodina-tion of the phenol is accomplished by means of an alkaline solution of iodine and potassium iodide. There is thus obtained benziodarone (4)... 

A variant on this theme contains mixed acyl groups. In the absence of a specific reference it may be speculated that the synthesis starts with the diacetyl derivative (15). Controlled hydrolysis would probably give the monoacetate (16) since the ester para to the ketone should be activated by that carbonyl function. Acylation with anisoyl chloride followed by reduction would then afford nisobuterol (18). 

Methenolone acetate A ndro tardy 1-0 estradiol Estradiol valerate Aniline Fentanyl Salicylanilide Anisoyl chloride Benzobromarone... 

Ammonium thiocyanate Anisoyl chloride Benzhydry bromide (diphenyl methyl bromide) Benzoyl chloride Benzyl bromide Benzyl chloride Benzyl chloroformate (benzyl chlorocarbonate) Butyl acid phosphate Chloracetyl chloride... 

Anisamide, m54 Anisic acids, m57, m58, m59 Anidisines, m48, m49, m50 Anisole, m55 p-Anisoyl chloride, m60 p-Anisyl alcohol, m61 Anthranilamide, all2 Anthranilic acid, all8 Araboascorbic acid, i61 APDC, p282 Arsanilic acids, all3... 

The role of the pyridone ring as a pharmacophore in cardiotonic agents such as amrinone (25-6) has been noted earlier very analogous activity is obtained with compounds in which the heterocylic ring is replaced by a pyridazinone. The synthesis of the first of these agents, pimobendan (35-6), starts with the acylation of the amino group in nitro-aniline (35-2) with anisoyl chloride (35-1) to give amide (35-3). 

A recent halogen-free benzofuran that shares many structural features with its predecessor shows activity in controlling arrythmias. The synthesis starts with an unusual scheme for building the furan ring. Reaction of the benzyl bromide (2-1) with triphenylphosphine leads to phosphonium salt (2-2). Treatment of the salt with valeryl chloride in the presence of pyridine results in acylation on the now highly activated benzylic carbon (2-3). That product cyclizes to the benzofuran (2-4) on heating with expulsion of triphenylphosphine. Friedel-Crafts acylation of (2-4) with anisoyl chloride in the presence of stannic chloride proceeds on the... 

Diphenylamine N-Methylaniline Charcoal Charcoal Anisoyl Chloride Anisoyl Chloride Cyclohexanol Cyclohexanone Cacodylic Acid... 

Chiral cyclohexadienes.1 The optically active amide 1, obtained by acylation of L-prolinol with o-anisoyl chloride, on reductive methylation gives 2 with high diastereoselectivity. The high stereoselectivity is attributed to chelation between... 

The reaction of anisoyl chloride (p-methoxybenzoyl chloride) with hexachlorophene (HCP) produces a derivative which can be detected in nanogram quantities by HPLC with UV detection [51]. The reaction product is the dianisate ester 2,2 -methylenebis(3,4,6-trichlorophenylp-methoxybenzoate). 

Method. To the residue in a test-tube is added 1 ml of 5% sodium hydroxide followed by 30 pi of anisoyl chloride. The tube is shaken for 1 min and left to stand at room temperature for 20 min in order to complete the reaction. At this time, 9 ml of water are added and the contents of the tube are shaken for 2 min. The mixture is then shaken with three 10-ml volumes of hexane. After centrifugation, the hexane solution is transferred quantitatively to a clean test-tube and evaporated to dryness. 1.0 ml of n-butyl chloride is added in order to dissolve the residue. An aliquot portion of the resulting solution is injected into the liquid chromatograph. The chromatographic apparatus consists of a stainless-steel column (2 ft. X 2.3 mm I.D.) which is packed with silica (particle diameter, 36-40 pm). The mobile phase is hexane-n-butyl chloride (11 9) at a flow-rate of 0.7 ml/ min. UV detection is carried out at 254 nm. The absorption spectrum of the HCP dianisate... 

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