Glycine amide

For amino acids having trivial names ending in -ine, the suffix -amide is added after the name of the acid (with elision of e for monoamides). For example, HjN—CHj—CO—NHj is glycin-amide. 

Sulzbach, H. M., P. v. R. Schleyer, and H. F. Schaefer, III. 1994. Interrelationship Between Conformation and Theoretical Chemical Shifts. Case Study on Glycine and Glycine Amide. J. Am. Chem. Soc. 116, 3967-3972. 

Maps and Conformational Transitions Between Low-Energy Conformers of N-Acety 1-N -Methyl Glycine Amide An Ab Initio Study at the 4-21G Lever with Gradient Relaxed Geometries. J. Mol. Struct. (Theochem) 124, 143-153. 

Fig. 7.19 Illustration of the additivity of conformational geometry functions for the -ro-tation in (CH3CO)(H)N-C(CH3)(H)(CONHCH3) (ALA). During the torsional motion about the N-C(a) bond of ALA, the interactions within the system are the same as those encountered during the N-C torsion in N-ethyl acetamide (NEA), plus those encountered during the N-C(a) torsion in N-acetyl N -methyl glycine amide offset by 120° as shown (GLY), minus those encountered during the N-C torsion in N-methyl acetamide (NMA).

There are also several reports of Li+-induced effects upon the endorphins (see ref. 162). More recently it has been shown that Li+ also enhances the activity of tyrosine aminopeptidase in rat pituitary gland [167]. This could result in changes in the levels of the enkephalins which are primarily degraded by aminopeptidases via cleavage of the tyrosine-glycine amide bond [168]. 

Interestingly, the favorable results obtained with tolmetin glycine amide were not shared by indomethacin glycine amide [25],... 

It has been shown that glycine amides of aminobenzophenones are readily converted to the corresponding benzodiazepines in vivo. Peptides which terminate in such a moiety should thus serve as a benzodiazepine prodrug after hydrolysis by peptidases. One of the glycine residues in lorzafone (194)is presumably removed metabolically in this manner to give a benzodiazepine precursor which spontaneously cyclizes. Acylation of benzophenone 190 with the trityl protected dipeptide 191, as its acid chloride 192, affords the amide 193. Removal of the trityl protecting group with acid yields lorzafone (194) [50]. 

Metal ions have been shown to promote the hydrolysis of glycine amide and of phenylalanylglycine amide (39). Cupric ion, cobaltous ion, and nickelous ion,... 

N-Substituted quinoxalines are obtained from N-substituted o-phenylenediamines. Thus methyl 2,3-dibromopropionate condenses with (V,A -bis(/7-toluenesulfonyl)-o-phenylenediamine to give l,4-bis(p-tolu-enesulfonyl)-2-methoxycarbonyl-1,2,3,4-tetrahydroquinoxaline (20).25 AVV -Disubstituted cyclohexane-1,2-diamines with suitable a/7-dihalides yield decahydroquinoxalines.26 Condensation of cyclohexane- 1,2-diones with glycine amide gives 2-oxo-5,6,7,8-tetrahydroquinoxalines.27... 

Cys-Tyr-Ile-Gln-AsivCys-Pro-Arg-GlyNH2 N terminal Glycine amide, C-terminal... 

What happens when the length of the substrate is extended in the direction of the N terminus The tyrosyl residue in the foregoing compound may be designated P,. For extended substrates which contain P,3 and additional residues (this includes most natural substrates) the Km values decrease very little from that of short substrates despite the larger number of "subsites" to which the substrate is bound. However, the maximum velocity is often much greater for the extended substrates than for short ones. Thus, for N-acetyltyrosyl-glycine amide Km is 0.017 M, only a little less than for N-acetyltyrosine amide, but fccat is 7.5 s 1,440 times greater than for the shorter substrate.229 288 289 Other examples have been tabulated by Fersht.279... 

Mn TG, PS-macro glycine amides oxidation of alkanes and alkenes [70]... 

The most commonly used amino acid buffers are glycine (pH 2 to 3 and 9.5 to 10.5), histidine (pH 5.5 to 6.5), glycine amide (pH 7.8 to 8.8), and glycylglycine (pH 8 to 9). These provide a more natural environment to cellular components and extracts however, they may interfere with some biological processes, as do the carboxylic acid and phosphate buffers. 

Chiral a-amino acids The lithium anion of the N-protected glycine amides 3, prepared by reaction of the pyrrolidine with [bis(methylthio)methylene]glycyl pivalic anhydride (DMAP), is alkylated with high diastereoselectivity. The (S)-amino acid (5) is obtained on acid hydrolysis. 

A variety of N-O-chelated glycine amide and peptide complexes of the type [CoN4(GlyNR R2)]3+ have been prepared and their rates of base hydrolysis studied.169 The kinetics are consistent with Scheme 8. Attack of solvent hydroxide occurs at the carbonyl carbon of the chelated amide or peptide. Amide deprotonation gives an unreactive complex. Rate constants kOH are summarized in Table 16. Direct activation of the carbonyl group by cobalt(III) leads to rate accelerations of ca. 104-106-fold. More recent investigations160-161 have dealt with... 

Table I. Major LMO contributions to 13Ca isotropic shielding in V-formyl-glycine amide, V-formyl-alanine amide, V-formyl-valine amide, and V-formy 1-phenylalanine amide (deMon program, PW91, uniform IGLOII basis set)... 

In addition to the glycinate Schiff base 1, glycine amide derivatives can be used as prochiral substrates for asymmetric alkylation under phase-transfer conditions. Kumar and Ramachandran examined the benzylation of various Schiff bases of... 

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