Beclomethasone nasal

Mucomyst) Beclomethasone, nasal (Beconase AQ) Beclomethasone, inhaler (QVAR)... 

Berger WE, Fineman SM, Lieberman P, Miles RM. Double-bhnd trials of azelastine nasal spray monotherapy versus combination therapy with loratadine tablets and beclomethasone nasal spray in patients with seasonal allergic rhinitis. Rhinitis Study Groups. Ann Allergy Asthma Immunol 1999 82(6) 535-41. 

Intranasal corticosteroids are the most effective treatment for allergic rhinitis during pregnancy. Beclomethasone and budesonide have been used most. Nasal cromolyn and first-generation antihistamines (chlorpheniramine, tripelennamine, and hydroxyzine) are also considered first-line therapy. Loratadine and cetirizine have not been as extensively studied. 

BECLOMETHASONE DlPROPIONATE NASAL SUSPENSION 25GM BOTTLE 6505012754811 EA 43 02 ... 

Beclomethasone - Adverse reactions occurring in 3% or more of patients include headache nasal congestion dysmenorrhea dyspepsia rhinitis pharyngitis coughing upper respiratory tract infection viral infections ... 

Beclomethasone dipropionate, triamcinolone acetonide, budesonide, flunisolide, and mometasone furoate are available as nasal sprays for the topical treatment of allergic rhinitis. They are effective at doses (one or two sprays one, two, or three times daily) that in most patients result in plasma levels that are too low to influence adrenal function or have any other systemic effects. 

Beclomethasone Dipropionate and Salbutamol Sulfate Nasal Spray... 

Glaucoma and ocular hypertension have been reported after dermal application of glucocorticoids for facial atopic eczema (SEDA-19,376) (64), and after treatment with beclomethasone by nasal spray and inhalation (SEDA-20, 373 65). 

Topical administration to the nose The safety of nasal glucocorticoids in the treatment of allergic rhinitis has been reviewed (434,435). The local application of glucocorticoids for seasonal or perennial rhinitis often results in systemic adverse effects. The use of nasal sprays containing a glucocorticoid that has specific topical activity (such as beclomethasone dipropionate or flunisolide) seems to reduce the systemic adverse effects, but they can nevertheless occur, even to the extent of suppression of basal adrenal function in children (436). Local adverse effects include Candida infection, nasal stinging, epistaxis, throat irritation (437), and, exceptionally, anosmia (438). 

Nasal budesonide or beclomethasone 100 micrograms bd for 3-9 months had no effect on the eyes in 26 patients who had undergone endoscopic sinus surgery (440). Ophthalmologic examination, tonometry, visual field testing, and biomicroscopic studies showed no evidence of ocular hypertension or posterior subcapsular cataract. 

Poynter D. Beclomethasone dipropionate aerosol and 55. nasal mucosa. Br J Clin Pharmacol 1977 4(Suppl 3) S295-... 

Nasal sprays are available as squeeze bottles, which would not be expected to give reproducible dosing. They are also available as metered-dose devices, which would be expected to give more reproducible dosing, as a mechanical actuation delivers a pre-determined volume to the patient. Thus the dose of drag received by the patient will be dependent on the concentration of drag in the formulation. Commercial examples of metered-dose sprays include Syntaris, Beconase and Rhinocort which deliver flunisolide, beclomethasone and budesonide respectively. 

Beclomethasone dipropionate is also used as a nasal spray in the prophylaxis and treatment of allergic and nonallergic rhinitis, and is used topically in the treatment of various skin disorders. It is generally applied as a cream or ointment. Beclomethasone salicylate has also been used topically. 

Stafenger, G. (1987). In vitro effect of beclomethasone dipropionate and flunisolide on the mobility of human nasal cilia. Allergy 42, 507-511. 

Corticosteroids — Beclomethasone dipropionate (17) aerosol has been tested extensively clinically. It is used prophylactically (400 fig per day), not therapeutically, in the treatment of chronic asthma, particularly in children.52 An evaluation of the drug has been published.53 One of the most important clinical advantages is that 1 7 effectively can replace oral corticosteroids in steroid-dependent patients and avoid many of the adverse effects of adrenal suppression.52,54 Most patients with impaired adrenal function due to oral corticosteroids show recovery of adrenal function within 6 months.55 The combination of 17 and disodium cromoglycate (DSCG) showed no additive therapeutic effects.5 Flunisolide (18), when administered as a nasal spray for 4 weeks during the hay fever season in 51 patients, showed significant symptomatic improvement with no systemic steroid effects observed.57... 

Juniper EF, Wilms DG, Guyatt GH, Ferrie PJ Aqueous beclomethasone dipropionate nasal spray in treatment of seasonal (ragweed) rhinitis. Can Med Assoc J 1992 147 887-892. (Ilb)... 

BECONASE GlaxoSmithKline (U.S./UK) Beclomethasone dipropionate 0.042% (micronised) SAI, Mr = 521 BKC, MCC, NaCMC, dex, Tw80, PE-OH (0.25% w/v), HCI, (pH 4.5-70) Amber neutral glass bottle with metering atomising pump and nasal adapter... 

Bernal, J.L. Del Nozal, M. J. Martin, M.T. Diez-Masa, J.C. Cifuentes, A. Quantitation of active ingredients and excipients in nasal sprays by high-performance liquid chromatography, capUlsiry electrophoresis and UV spectroscopy, J.ChromatogrA., 1998, 823, 423-431. [beclomethasone dipropionate fluticasone dipropionate beclomethasone fluticasone benzalkonium benzalkonium chloride phenylethyl... 

Another randomised double-blinded trial of 19 patients evaluated e effect of nasal beclomethasone on patients with pre-existing, controlled primary open-angle glaucoma or ocular hypertension [31 ]. During a treatment period of 6 weeks, intranasal steroids did not significantly affect intraocular pressure in these patients. 

Lofkvist, T. and Svensson, G. (1975) An open assessment of becotidc (beclomethasone dipropionate) nasal spray in seasonal allergic rhinitis. Acta atlerg. (Kbh.), 30, 227. 

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