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Batch process defined

For a continuous SMB process, the specific identified amount or batch produced is defined by unit of time in such a way that ensures a homogeneous material and quality within specified limits. In the case of a continuous SMB production run a batch is defined by the amount produced in a fixed time interval. A time limitation during manufacturing using SMB is established by the same fixed time interval as the batch. The duration of the production phase is thus established, which does not affect the quality of the drug substance [66]. [Pg.277]

It should include explicit state logic, in which a batch process proceeds clearly from one state to another through a series of explicitly defined transitions. [Pg.472]

Analogous to time as a measure of batch process performance, space-time (r) can be defined for a continuous reactor ... [Pg.85]

Campaign processes have also variable production time. Different to continuous production, campaign production is related to multi-purpose assets, where different processes and products can run on the same production resource and change-over decisions between campaigns need to be taken. Finally, batch processes have a defined lot size, start and end time of production as well as throughput. [Pg.80]

The maximum permissible temperature ("TeXo") is the maximum permissible temperature at which a material or reaction mixture can just be handled without risk. This temperature needs to be defined with due consideration for the process parameters and the measuring methodology that was used to determine the material characteristics. For example, the maximum permissible temperature in a continuous process can be set at a higher level than in a batch process. This is due to the fact that in a continuous process materials are only briefly exposed to high temperatures while in a batch process materials can be exposed to high temperatures for extended periods of time. [Pg.242]

A batch is defined as that quantity of material which has been manufd by some unit chem process and subjected to some physical mixing opn intended to make the final product substantially uniform... [Pg.93]

Due to this principle, a batch B defined for quality control purposes consists of a fixed number of n mini batches (subunits), i.e., B=nb.Thus, a tight in-process control of the mixing/granulation (6-9) and drying step (14) provides an excellent batch record of the quasi-continuous production of granules and an excellent opportunity for a continuous validation of the process and the equipment (14-18,32-34). [Pg.216]

In a retrofit batch design, we optimize the batch plant profitability defined as the total production value minus the cost of any new equipment. The objective is to obtain a modified batch plant structure, an operating strategy, the equipment sizes, and the batch processing parameters. Discrete decisions correspond to the selection of new units to add to each stage of the plant and their type of operation. Continuous decisions are represented by the volume of each new unit and the batch processing variables which are allowed to vary within certain bounds. [Pg.9]

Most API processes are run, in all steps, as batch processes for a number of reasons, among them the fact that the typical development of an API process with small quantities is done as a batch process (development history). Also it is straightforward to define a subset of material as a batch for regulatory and release purposes. [Pg.31]

To follow this approach subsystem layout and functions as well as microfabrication processes have to be selected, which are apt to generate and integrate the various subsystems of a mass spectrometer into one substrate in one batch process, i.e., all the components are defined in their geometry and orientation among each on one photo mask, which is then transferred into features in the substrate. Thus, submicron accuracy of device features and their orientation and adjustment can reproduc-ibly be guaranteed, i.e., many identical devices can be fabricated simultaneously in one run. This, however, also means that all the subsystems are fabricated in the same material within a narrow range of the necessarily different dimensions. [Pg.426]

The importance of modeling batch processing systems forces a review of the mathematical analysis needed to set up and solve the models. The mathematical definition of physical problems involves (1) identification, (2) expression of the problem in mathematical language, (3) finding a solution, and (4) evaluating the solution. The completion of these steps in the order established determines whether a solution can be attained. The problem must be identified before one spends time setting up equations these and the initial and boundary conditions that define the problem must be well established before a solution is attempted then a solution can be obtained and evaluated. [Pg.86]

As can be observed in Figure 10.1, information from the process (value of the temperature measured by the sensor) arrives at the control loop, which defines it as a closed loop. This is the case for most controllers installed in bioreactors. If the decisions of a controller do not take into account any of the monitored information of the process, it is called an open loop. An example of an open loop is a fed-batch process, where it... [Pg.260]

Dispersion polymerization is defined as a type of precipitation polymerization by which polymeric microspheres are formed in the presence of a suitable steric stabilizer from an initially homogeneous reaction mixture. Under favorable circumstances, this polymerization can yield, in a batch process, monodisperse, or nearly monodisperse, latex particles with a relatively large diameter (up to 15 pm) [103]. The solvent selected as the reaction medium is a good solvent for both the monomer and the steric stabilizer, but a non-solvent for the polymer being formed and therefore a selective solvent for the graft copolymer. This restriction on the choice of solvent means that these reactions can be carried out... [Pg.157]

In batch processes, the time of exposure to heat is well defined. This is also true of continuous processes in which the liquid to be evaporated is passed only once through the heater. In continuous processes, is where the liquid is recirculated through the heater, the average residence time, a, is given by the ratio. [Pg.3880]


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Batch processes

Batch processing

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