Bacterial cellulose artificial blood vessels

Klemm, D., Schumann, D., Udhardt, U., and Marsch, S. (2001). Bacterial synthesized cellulose—artificial blood vessels for microsurgery, Pohrm.. Sri.. 26,1561-1603. 

Klemm D., Schumann D., Udhardt U., Marsch S., Bacterial synthesized cellulose - Artificial blood vessels for microsurgery, Prog. Polym. ScL, 26, 2001, 1561. 

Klemm D, Schumann D, Udhardt U, Marsch S (2(X)1) Bacterial synthesized cellulose— artificial blood vessels for microsurgery. Prog Pol5un Sci 26 1561-1603... 

D. Klemm, D. Schumann, U. Udhardt, and S. Marsch, Bacterial synthesized cellulose -artificial blood vessels for microsurgery. Progress Polym. ScL, 26,1561-1603,2001. 

Klemm, D Schumann, D Udhardt, U Marsch, S. Bacterial synthesized cellulose-artificial blood vessels for microsurgery. Progress in Polymer Science, 2001, 26, 1561-1603. 

Because of the extraordinary supramolecular structure and exceptional product characteristics as high-molecular and high-crystalline cellulosics with a water content up to 99%, nanocelluloses require increasing attention. This review assembles the current knowledge in research, development, and application in the field of nanocelluloses through examples. The topics combine selected results on nanocelluloses from bacteria and wood as well as their use as technical membranes and composites with the first longtime study of cellulosics in the animal body for the development of medical devices such as artificial blood vessels, and the application of bacterial nanocellulose as animal wound dressings and cosmetic tissues. 

Our investigations on BASYC (BActerial-SYnthesized Cellulose) as artificial blood vessel and cuff for nerve suturing [65] are reviewed below. Because of... 

Bacterial Cellulose has been shown to be a highly effective wound dressing material. In fact, the results of burns, diabetic ulcer, healing process can be show in Figs. 10.5 and 10.6a,b. The biomedical applications of BC include meniscus replacements (pig meniscus on the left, BC meniscus on the right), artificial blood vessels and wound dressing for skin healing [12, 20, 21] (Fig. 10.7). 

Fink, H., 2009. Artificial Blood Vessels Studies on Endothelial Cell and Blood Interactions with Bacterial Cellulose (Doctoral thesis). University of Gothenburg. Sahlgrenska Academy, Institute of Clincial Sciences. Department of Surgery. 

Within the medicinal field, bacterial cellulose alone was shown to be a versatile material for the construction of artificial blood vessels, an application which clearly benefits from the structural features of cellulose in combination with its chemical stability under physiological conditions [52], Other applications use cellulose for the production of implantable capsules [53], and even sensors [54], Another interesting biomedical application is the use of cellulose in films supporting wound healing, due to the hydrating characteristics of these cellulose-containing films [55], Besides, cellulose and cellulose derivatives are used as haemostatic agents [56], The latter two fields of application for cellulose have just recently been reviewed in the cited literatiu-e, and are thus not discussed in detail here. 

PU is a strong, hard-wearing, tear-resistant, flexible, oil-resistant, and blood-compatible polymer. The functional properties of natural macromolecules can be merged with those of synthetic polymers having controllable structures and properties for the production of polymer/protein hybrids. In tissue engineering, silk fibroin/PU blend film can be used as scaffold material for artificial blood vessels [466] (Figure 2.62). Bacterial synthesized cellulose, which was designed... 

Bacterial cellulose has been investigated for its potential use as artificial blood vessels because it carries a lower risk of blood clots. Native bacterial cellulose has several mechanical properties that are superior to those of many currently used synthetic materials such as polypropylene, polyethylene terephtalate, and cellophane. These properties include shape retention and tear resistance. 

However, in the last decade the main application of bacterial cellulose has been in the biomedical materials field [13,46,55-57], Due to its unique nanostructure and properties, microbial cellulose is a nattnal candidate for numerous medical and tissue-engineered apphcations. In fact, much work has already been focused on designing ideal biomedical devices from BNC, such as artificial skin, blood vessels, cornea, urethra, bone, cartilage, porcine knee menisci, and heart valve prosthesis as well as deliveries of drug, hormone and protein [58-62], Figure 2,5 illustrates some of the prospects for the various biomedical applications of BNC-based materials. 

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