B-cell neoplasms

Precursor B-cell neoplasm Precursor B-lymphoblastic leukemia/lymphoma Mature (peripheral) B-cell neoplasms B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma... 

T4. Tsuruda, K., Yamada, Y, Hirakata, Y, Sugahara, K., Maeda, T, Atogami, S., Tomonaga, M., and Kamihira, S., Qualitative and quantitative characterization of Fas (APO-I/CD95) on leukemic cells derived from patients with B-cell neoplasms. Leuk. Res. 23,159—166 (1999). 

IFN-a Family. There are 14 human genes that comprise the IFN-a family. These genes generally encode mature polypeptides with either 165 or 166 amino acids and have a 15% to 25% variation in primary amino-acid sequence. Minor variants consisting of one or two amino-acid differences account for multiple alleles. Thirteen separate proteins are expressed from these 14 genes (Table 7.1), each with a different profile of antiviral and antiproliferative activity [40,41]. Evidence for cell specificity of IFN-a subtypes has been reported. For example, IFN-al has greater antiproliferative effects on B-cell neoplasms, whereas IFN-a2 is more specific for other malignancies [42]. When assayed on human cells, IFN-al has less antiviral activity than IFN-a2 [43]. Nevertheless, IFN-al has potent antiviral activity in bovine-, feline-, and primate-derived cells [44]. Fur-... 

Flairy-cell leukemia (FICL) is an infrequent B-cell neoplasm characterized by the presence of small lymphocytes with numerous cytoplasmic projections. These cells are found in the peripheral blood and in bone marrow. HCL patients undergoing IFN-a2 therapy may show a decrease in bone marrow inhltration and normalization of peripheral hematologic parameters. More than 85% of patients have objective evidence of partial or complete hematologic response when treated with IFN-a2... 

Vasef, M. A., Medeiros, L. J., Koo, C., McCourty, A., and Brynes, R. K. 1997a Cyclin D1 immunohistochemical staining is useful in distinguishing mantle cell lymphoma from other low-grade B-cell neoplasms in bone marrow. Am. J. Clin. Pathol. 108 302-307. 

Lymphoid neoplasms are divided into three main categories B cell neoplasms, T/NK cell neoplasms, and Hodgkin lymphoma. The B and T/NK cell neoplasms are further divided into precursor B and mature B cell neoplasms and into precursor T and mature T/NK cell neoplasms, respectively. The mature B cell and T/NK neoplasms consist of a variety of different neoplastic lymphoid entities, which can be grouped based on primary clinical presentation or based on median survivals without treatment reflecting biologic behavior. However, due to the large number of separate entities, only the more common lesions will be discussed. For information concerning the entities not discussed here or for more in-depth information, the... 

B cell neoplasms based on morphology, immunophenotype, and genotype often, but not always, correspond to stages of B cell development. However, some B cell lymphomas either do not clearly correspond to a specific developmental stage (i.e., appear to be of variable origin such as chronic lymphocytic leukemia/small lymphocytic lymphoma) or do not appear to be related to any known stage of normal development (i.e., hairy cell leukemia) (H10). 

H10. Harris, N. L., Mature B-cell neoplasms Introduction. In World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues (E. S. Jaffe, N. L. Harris, H. Stein, and J. W. Vardiman, eds.), pp. 121-126. IARC Press, Lyon, 2001. 

R13. Royer, B., Cazals-Hatem, D., Sibilia, J., Agbalika, F., Cayuela, J. M., Soussi, T., Maloisel, F., Clauvel, J. P., Brouet, J. C., and Mariette, X., Lymphomas in patients with Sjogren s syndrome are marginal zone B-cell neoplasms, arise in diverse extranodal and nodal sites, and are not associated with viruses. Blood 90, 766-775 (1997). 

Anti-CD20 mAbs have also been developed for use in the radioimmunotherapy (RIT) of B-cell neoplasms. Compared with unlabeled or naked mAh strategies, RIT has the theoretical advantage of increased potency via radionuclide emission that does not depend on host immune mechanisms, and so-called bystander toxicity in which cancer cells not bound by mAbs may still be lethally irradiated if located sufficiently close to bound mAh on other cells. An additional rationale for RIT in the treatment of NHL and other hematologic malignancies is the exquisite sensitivity of many of these diseases to radiation therapy. 

High risk of EBV related B cell neoplasms, skin cancer, melanoma, leukemia, breast cancer, adenocarcinoma... 

B-cell Neoplasms Precursor B-cell acute lymphoblastic v 100 40-50 20-25 20-30 50-60 70-80... 

Precursor B cell neoplasm Precursor T cell neoplasm Nodular... 

The risk of NHL for patients with AIDS is increased about 150- to 250-fold as compared to the general population." AIDS-related lymphoma arises as a consequence of long-term stimulation and proliferation of B lymphocytes from HIV and the reactivation of prior EBV infection due to HIV-induced immunosuppression. " AIDS-related lymphoma usually occurs late in the course of HIV infection and is the cause of death in about 15% of HIV-infected individuals. Although HIV infects T cells, more than 95% of AIDS-related lymphomas are B-cell neoplasms. About 60% of AIDS-related lymphomas are classified as Burkitt s (30%) or diffuse large B-ceU type (30%). "... 

Lymphocyte depletion type (Figs. 5.1 and 5.1) NLPHL is a B-cell neoplasm derived from germinal... 

Mason DY, Cordell JL, Brown MH, et al. CD79a A novel marker for B-cell neoplasms in routinely processed tissue samples. Blood. 1995 86 1453-1459. 

Harris NL, Bhan AK. B-cell neoplasms of the lymphocytic, lym-phoplasmacytoid, and plasma cell types immunohistologic analysis and clinical correlation. Hum Pathol. 1985 16(8) 829-837. 

Hammer RD, Click AD, Greer JP, et al. Splenic matginal zone lymphoma. A distinct B-cell neoplasm. Am J Surg Pathol. 1996 20(5) 613-626. 

Davis RE, Dorfman RF, Warnke RA. Primary large-cell lymphoma of the thymus a diffuse B-cell neoplasm presenting as primary mediastinal lymphoma. Hum Pathol. 1990 21(12) 1262-1268. 

Ferry JA, Harris NL, Picker LJ, et al. Intravascular lymphomatosis (malignant angioendotheliomatosis). A B- cell neoplasm expressing surface homing receptors. Mod Pathol. 1988 1(6) 444-452. 

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