Autologous artery

Stefanadis, C., Toutouzas, K., Tsiamis, E., Kallikazaros, L, Stralos, C., Vlachopoulos, C., Vavuranakis, M., and Toutouzas, P., Implantation of stents covered by autologous arterial grafts in human coronary arteries A new technique, y. Invasive Cardiol., 2CKK)a 12(1) 7-12. 

In cats intracisternal injection of 0.5 ml/kg of fresh unheparinized autologous arterial blood resulted in a progressive decrease in cerebral blood flow (caudate nucleus), which reached a level of approximately 50% below normal at three hours after subarachnoid haemorrhage (Hall and Braugh-LER 1988). Pre-treatment with the antioxidant, a-tocopherol (1000 lU) almost completely prevented this decrease in blood flow. 

Fig. 5. In coronary bypass, an autologous saphenous vein is used to provide critical blood to the heart muscle, bypassing a blockage in the coronary artery.

They also seeded autologous vSMC and ECs obtained from ovine carotid arteries to study autologous tissue-engineering blood vessels in the descending aorta of juvenile sheep. They found that after three months implantation, grafts were fully patent, without dilatation, occlusion, or intimal thickening. A continuous luminal EC layer was formed. However, after six months ... 

Stock UA, Sakamoto T, Hatsuoka S, Martin DP, Nagashima M, Moran AM, Moses MA, Khalil PN, Schoen FJ, Vacanti JP, and Mayer JE Jr. Patch augmentation of the pulmonary artery with bioabsorbable polymers and autologous cell seeding. J Thorac Cardiovasc Surg, 2000, 20, 1158-1168. 

The intracoronary route has also been used to deliver autologous MSCs. Chen et al. [108] recently reported the first randomized clinical trial of these cells in 69 patients who imderwent a primary percutaneous coronary intervention within 12 h after an AMI. Either MSCs or saline was injected into the target coronary artery. At 3-month follow-up, left ventricular perfusion and the LVEF had significantly improved in the treatment group. 

Fuchs S, Satler LF, Kornowski R, Okubagzi P, Weisz G, Baffour R, Waksman R, Weissman NJ, Cerqueira M, Leon MB, Epstein SE. Catheter-based autologous bone marrow myocardial injection in nooption patients with advanced coronary artery disease a feasibility study. J Am Coll Cardiol 2003 41 1721-1724. 

F. J. Veith, S.K. Gupta, E. Ascer, S. White-Flores, R.H. Samson, L.A. Scher, J.B. Town, V.M. Bernard, P. Bonier, W.R. Flinn, P. Astelford, J.S.T. Yao, J.J. Bergan, Six-year prospective multicenter randomized comparison of autologous saphenous vein and expanded polytetrafluoroethylene grafts In Infraingulnal arterial reconstructions, J. Vase. Surg. 3(1) (1986) 104-114. 

To assess the feasibility of angiogenic cell therapy for patients with peripheral artery diseases, we organized a randomized controlled clinical trial using CDI33+ cells implanted in ischemic limbs. The goal of the study is to demonstrate that intramuscular implantation of autologous human CD 133 + cells into ischemic limbs effectively induces collateral vessel formation, improving function, and trophic ischemic lesions (79-81). 

Many surgeons routinely use a patch of autologous vein, or synthetic material, to close the artery, enlarge the lumen and so reduce the risk of restenosis and, more importantly, of stroke. Patching increases the surgery time and there are complications, including rupture... 

Recidivation is generally due to undetected small intra-hepatic foci. Especially in cirrhosis, the recurrence rate is very high as a result of this factor. A further cause of recidivation after primary RO resection is attributed to the multicentricity of the HCC, i. e. synchronic or metachronic development of additional tumours which are independent of the primary tumour. Therefore, the secondary prophylaxis takes on a special meaning (systemic or intra-arterial chemotherapy, interferon, retinoids, autologous lymphocyte transfusion, etc.). An increase in ornithine decarboxylase and spermidine is apparently a high risk factor for recurrence. Even after recidivation, repeated resection or interventional procedures (e.g. RFTA) are sometimes successful. 

A model that predicts accurately thromboembolic risk associated with the use of biomaterials is still needed. Utilizing minimal surgical techniques, catheters were placed in goat carotid arteries, and subsequent analysis in real time was performed noninvasively of net platelet retention of autologously labeled nlIn platelets. We concentrated on acute animal studies using polyethylene catheters. Price et al. used a very similar model in dogs, obtaining similar results (9). 

Remodeling of autologous saphenous vein graft interposed into porcine carotid artery involves fibroblast infiltration from the adventitia... 

Fig.l8. Identification of the role played by converted adventitial cells in the neointima formation. Carotid artery was first pulse-labeled with bromo-deoxyuridine (BrdU) soon after overstretching injury (black dots), then an autologous (not treated) segment of saphenous vein was interposed into the injured/treated artery. Three weeks after surgery, BrdU-positive cells were found both in the arterialized venous media and in the neointima (see Ref. [370] for details). 

Reversed segments of autologous saphenous vein can be used as appropriate conduits. Particularly in coronary revascularization, the internal mammary arteries and the radial arteries have widely been used [3]. However, autologous vessels may be insufficient for multiple or repeated bypasses and/or saphenous veins may have varicose degenerative alterations. Therefore, allograft arteries and veins as well as synthetic tubes have been developed, but they proved to be less satisfactory as conduits [4, 5] particularly, synthetic grafts with an internal diameter of 6 mm or less are prone to thrombus induction and occlusion [6]. 

Hinrichs, W. L. J., Zweep, H.-R, Satoh, S. et al.. Supporting, microporous, elastomeric, degradable prostheses to improve the arterialization of autologous vein grafts. Biomaterials, 15(2), 83, 1994. 

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