Bioabsorbable polymers

Polydioxanone (PDS) is completely elirninated from the body upon absorption. The mechanism of polydioxanone degradation is similar to that observed for other synthetic bioabsorbable polymers. Polydioxanone degradation in vitro was affected by gamma irradiation dosage but not substantially by the presence of enzymes (39). The strength loss and absorption of braided PDS, but not monofilament PDS, implanted in infected wounds, however, was significantly greater than in noninfected wounds. 

Stock UA, Sakamoto T, Hatsuoka S, Martin DP, Nagashima M, Moran AM, Moses MA, Khalil PN, Schoen FJ, Vacanti JP, and Mayer JE Jr. Patch augmentation of the pulmonary artery with bioabsorbable polymers and autologous cell seeding. J Thorac Cardiovasc Surg, 2000, 20, 1158-1168. 

Shawe, S., Buchanan, F., Harkin-Jones, E. and Farrar, D. (2006) A study on the rate of degradation of the bioabsorbable polymer polyglycolic acid (PGA). Journal of Materials Science, 41, 4832 4-838. 

Grube E, Sonoda S, Ikeno E et al. Six- and twelve-month results from first human experience using everolimus-eluting stents with bioabsorbable polymer. Circulation 2004 ... 

This mechanism is applied to bioabsorbable polymer matrices in which drug elution is a function of both the matrix degradation... 

MAJOR TYPES OF BIOABSORBABLE POLYMERS AND POSSIBLE MODES OF BIOABSORPTION... 

About two decades ago, most bioabsorbable polymers were natural polymers or derivatives thereof Scientific interest in totally synthetic bioabsorbable polymers has grown considerably since the early seventies because of their relatively low tissue reaction and because of their more predictable in vitro and in vivo properties as compared with the natural materials. Bioabsorbable polymers can be classified into three major groups soluble, solubilizable, and depolymerizable. The structural features and possible mode of bioabsorption of these polymers are outlined as follows. 

Sheridan, M.H. Shea, L.D. Peters, M.C. Mooney, D.J. 59. Bioabsorbable polymer scaffolds for tissue engineering capable of sustained growth factor delivery. J. Control. Release... 

Journal of Applied Polymer Science 74, No.4, 24th Oct. 1999, p.937-47 FORMATION OF ANTIBIOTIC, BIODEGRADABLE/BIOABSORBABLE POLYMERS BY PROCESSING WITH NEOMYCIN SULFATE AND ITS INCLUSION COMPOUND WITH BETA-CYCLODEXTRIN Lei Huang Taylor H Geiber M Omdorff P E ... 

Pratt, L. and Chu, C.C., 1994a. The effect of electron donating and electron withdrawing substituents on the degradation rate of bioabsorbable polymers a semi-empirical computational study. /. Mol. Struct., 304 213-226. 

Bioabsorbable polymers such as aliphatic polyesters from the poly ((z-hydroxy acids) family, especially polylactic acid (PLA), are well known bioabsorbable materials and are widely used for biomedical applications... 

Therefore, the combination of a bioabsorbable polymer such as PLA with a soluble CaP glass leads to a fully degradable composite material with a high bone regenerative potential. 

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