Autoimmune deficiency syndrome

The retroviruses associated with AIDS (autoimmune deficiency syndrome), namely, human immunodeficiency virus types 1 and 2 (HIV-1, -2), display considerable genome sequence variability not only between isolates from different individuals but also between isolates from the same... 

Figure 3 A few examples of marketed drugs that were discovered with the aid of computers. Norfloxacin is an antibiotic derived in a quantitative structure-activity study. Losartan is an antihypertensive agent that resulted from an extensive structure-activity study which obtained its initial direction from molecular modeling. Indinavir is an antiviral drug for treating autoimmune deficiency syndrome that was found with input from crystallography and molecular mechanics and molecular simulation calculations...

AGEPC l-O-alkyl-2-acetyl-iw-glyceryl-3-phosphocholine also known as PAF and APRL AH Acetylhydrolase AID Autoimmune disease AIDS Acquired immune deficiency syndrome... 

Stoelinga, G. B. A., van Muster, P. J. J., and Slooff, J. P., Antibody deficiency syndrome and autoimmune haemolytic anaemia in a boy with isolated IgM deficiency. Dysimmunoglobulinaemia Type 5. Acta Paediat. Scand. 58, 352-362 (1969). 

Medicinal products for human use containing a new active substance which, on the date of entry into force of this Regulation, was not authorized in the Community, for which the therapeutic indication is the treatment of any of the following diseases acquired immune deficiency syndrome, cancer, neurodegen-erative disorder and diabetes (and with effect from 20 May 2008 autoimmune diseases and other immune dysfunctions, and viral diseases). 

The immunological disorders of Indian childhood cirrhosis and of tropical splenomegaly syndrome, where there are disturbances of the immunoglobulin synthesis as well as defects of cellular immune responses, may be the results of a combination of infections and perhaps certain types of unusual autoimmune phenomena—or even to vitamin deficiencies. 

Nakamura, A., T. Yuasa, A. Ujike, M. Ono, T. Nukiwa, J. V. Ravetch, and T. Takai. 2000. Fcgamma receptor IIB-deficient mice develop Goodpasture s syndrome upon immunization with type IV collagen a novel murine model for autoimmune glomerular basement membrane disease. J. Exp. Med. 191 899-906. 

Preparations for intravenous administration are mainly used in patients with general immune deficiency states (primary or secondary) or diseases like idiopathic thrombo-cjhopenic purpura (ITP) and autoimmune diseases (5,6). Neurological disorders (for example Guillain-Barre syndrome and chronic demyelinating polyneuropathy) have been treated with intravenous immunoglobulin (7-9). 

TSH is required for normal thyroid secretion. Thyroid atrophy and decreased thyroid secretion follow pituitary failure. Pituitary insufficiency may be caused by destruction of thyrotrophs by either functioning or nonfunctioning pituitary tumors, surgical therapy, external pituitary radiation, postpartum pituitary necrosis (Sheehan s syndrome), infiltrative processes of the pituitary such as metastatic tumors, tuberculosis, histiocytosis, and autoimmune mechanisms. In all these sitnations, TSH deficiency most often occurs in association with other pituitary hormone deficiencies. 

Many primary immunodeficiency syndromes in which genetic defects are known or suggested are associated with a variety of autoimmune manifestations. A selection of immunodeficiencies together with their associated autoimmune manifestations is shown in Table 2. Immune dysregulation, persistent antigen stimulation, recurrent tissue damage, and defective clearance of immune complexes are pathogenetic factors that may lead to autoimmunity in immuno-deficient individuals (Etzioni, 2003). 

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