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Atherosclerosis infections

Vitamin C status is supposed to play a role in immune function and to influence the progression of some chronic degenerative diseases like atherosclerosis, cancer, cataracts, and osteoporosis. The role of vitamin C in immune function, especially during common cold and upper respiratory tract infection, is the subject of lively debate. The exact mechanisms of action have not yet been fully elucidated, but the results of several trials point to a reduced duration and intensity of infections in subjects consuming high amounts of vitamin C (200-1000 mg/d). However, the incidence of common cold was not influenced significantly (24). [Pg.1294]

These proteins are called acute phase proteins (or reactants) and include C-reactive protein (CRP, so-named because it reacts with the C polysaccharide of pneumococci), ai-antitrypsin, haptoglobin, aj-acid glycoprotein, and fibrinogen. The elevations of the levels of these proteins vary from as little as 50% to as much as 1000-fold in the case of CRP. Their levels are also usually elevated during chronic inflammatory states and in patients with cancer. These proteins are believed to play a role in the body s response to inflammation. For example, C-reactive protein can stimulate the classic complement pathway, and ai-antitrypsin can neutralize certain proteases released during the acute inflammatory state. CRP is used as a marker of tissue injury, infection, and inflammation, and there is considerable interest in its use as a predictor of certain types of cardiovascular conditions secondary to atherosclerosis. Interleukin-1 (IL-1), a polypeptide released from mononuclear phagocytic cells, is the principal—but not the sole—stimulator of the synthesis of the majority of acute phase reactants by hepatocytes. Additional molecules such as IL-6 are involved, and they as well as IL-1 appear to work at the level of gene transcription. [Pg.583]

Ischemic stroke has numerous causes. Cerebral infarction may result from large artery atherosclerosis, cardiac embolism, small artery lipohyalinosis, cryptogenic embolism, or, more rarely, from other diverse conditions such as arterial dissection, infective endocarditis, and sickle cell disease. Arterial occlusion is the cause of at least 80% of acute cerebral infarctions. " ... [Pg.39]

The response-to-injury hypothesis states that risk factors such as oxidized LDL, mechanical injury to the endothelium, excessive homocysteine, immunologic attack, or infection-induced changes in endothelial and intimal function lead to endothelial dysfunction and a series of cellular interactions that culminate in atherosclerosis. The eventual clinical outcomes may include angina, myocardial infarction, arrhythmias, stroke, peripheral arterial disease, abdominal aortic aneurysm, and sudden death. [Pg.111]

Although we have discussed briefly the implications of biochemical individuality for alcoholism, for gout, and for arthritis, these are merely examples. A host of other diseases need to be attacked with the same point of view and hold the same promise of success. These include multiple sclerosis, muscular dystrophy, myasthenia gravis, atherosclerosis, essential hypertension, ulcers, diabetes, epilepsy, rheumatic heart disease, nephrosis, liver cirrhosis, congenital heart disease (as well as a host of other malformations which probably involve nutritional deficiencies during fetal life) and even infective diseases such as tuberculosis or poliomyelitis. [Pg.242]

The potential use of gene therapy has since expanded as conditions such as cancer, atherosclerosis, transplant operations, and infectious disease are now viewed as suitable targets for intervention. For example, HTV and parasitic infection (2-5). Furthermore, the ability to transfer genes into cell in vitro is also an important tool in the research of gene expression. [Pg.294]

Infection with cytomegalovirus (a common virus of the herpes virus group) is associated with atherosclerosis. [Pg.511]

Atherosclerosis can result in ischemia of peripheral muscles just as coronary artery disease causes cardiac ischemia. Pain (claudication) occurs in skeletal muscles, especially in the legs, during exercise and disappears with rest. Although claudication is not immediately life-threatening, peripheral artery disease is associated with increased mortality, can severely limit exercise tolerance, and may be associated with chronic ischemic ulcers and susceptibility to infection. [Pg.266]

The herbs in this group can be selected as chief and deputies to dissolve congealed blood they can also stimulate blood circulation. They are mainly used to treat the more severe or chronic syndromes of blood stagnation where the blood becomes thicker and blood clots are formed, such as in atherosclerosis, hyperlipemia, thrombosis, endometriosis, adhesions in chronic infection and after surgical operations. [Pg.275]

Bell pepper is rich in antioxidant vitamin C. It helps to fight off colds, asthma, bronchitis, respiratory infections, cataracts, macular degeneration, angina, atherosclerosis, and cancer. [Pg.211]

Besides glucose, other analytes of clinical value can be possibly quantified by noninvasive spectral analysis. In vivo concentrations of lactate and urea are examples. The concentration of lactate in blood is used clinically to follow intensive care treatments, to identify cardiac or liver failure, to determine hypoxia of tissues from atherosclerosis, and to detect bacterial infection. In vivo urea levels are valuable for optimizing hemodialysis treatments and tracking the accumulation of toxins for people with end-stage renal failure or recent kidney transplant recipients. [Pg.333]

The prognosis of SLE has much improved during recent decades. The overall 10-year survival rate in retrospective series is 75-85% (Ul). The major cause of early death is usually active disease, whereas the leading cause of late death is atherosclerosis (A2). Infection is a major cause of mortality in all stages of SLE (G16). In our experience with SLE in children, the 5-year renal and patient survival rates were 93.1% and 91.08%, respectively (Y4). Several features of SLE have been associated with mortality in a multivariate model (A3). These features include renal damage, thrombocytopenia, very active disease at presentation, and lung involvement. Despite the large decrease in the mortality of SLE patients, there are still many issues to be resolved (G16). [Pg.133]

It is used in the treatment of scurvy, postoperative cases, and healing bedsores and chronic leg ulcers. Vitamin C increases the absorption of iron during anemia and is frequently combined with ferrous salts. It is used in urinary tract infections to acidify urine. Large doses of vitamin C have been tried to cure everything from the common cold to cancer, with not much success. The usefulness of vitamin C in asthma, cancer, atherosclerosis, psychologic symptoms, and fertility is doubtful. Ascorbic acid is well tolerated in large doses and may cause rebound scurvy on withdrawal. There is a possibility of forming urinary stones. [Pg.282]


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See also in sourсe #XX -- [ Pg.118 ]




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Atherosclerosis

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