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Asthma pharmacological treatment

The desired outcome in the pharmacological treatment of asthma is to prevent or relieve the reversible airway obstruction and airway hyperresponsiveness caused by the inflammatory process. Therefore, categories of medications include bronchodilators and anti-inflammatory drugs. [Pg.253]

Asthma is the most serious of the atopic diseases and has become epidemic, affecting more than 155 million individuals in the developed world. It is the most common chronic childhood disease in developed nations [1], and carries a very substantial direct and indirect economic cost worldwide [2]. A number of pharmacological treatments have been developed for asthma. These treatments have a modest efficacy overall, due in part to widely variable individual responses to asthma drugs. Because of such variability, it is clear that some of the substantial resources expended on asthma medication, estimated to exceed U.S. 3 billion per annum in the U.S. alone [3], would be better spent targeting those patients who... [Pg.215]

Although medication nonadherence is the primary focus of this article, it is only one form of nonadherence. Poorer health outcomes may also result when a patient does not adhere to recommended lifestyle changes, such as exercise or smoking cessation, or to prescribed non-pharmacologic interventions, such as physical therapy or dietary plans. Pharmacists who counsel patients with chronic diseases, such as asthma, hypertension, or diabetes, need to assess and promote adherence to these non-pharmacologic treatments as well. [Pg.10]

National Institutes of Health, National Heart, Lung and Blood Institute. NAEPP Expert Panel Report Managing Asthma During Pregnancy Recommendations for Pharmacologic Treatment—Update 2004. NIH Publication No. 04-5246, March 2004. [Pg.534]

The pharmacological treatment of established emphysema resembles that of asthma largely because the inflammatory/bronchospastic component of a patient s disease is the aspect amenable to therapy. For patients with emphysema who have a significant degree of active inflammation with bronchospasm and excessive mucus production, symptomatic use of inhaled ipratropium or a adrenergic agonist may be helpful. Ipratropium or tiotropium usually produces about the same... [Pg.473]

The inflammatory effects seen in asthma result from the release of physiologically active chemicals from a variety of inflammatory cells. Pharmacological treatment, therefore, uses anti-inflammatory drugs (corticosteroids), mast cell stabilizers, leukotriene modifiers, and IgE monoclonal antibodies. Figure 44.3 depicts the overall approach to the pharmacological treatment of asthma. [Pg.1923]

The intensity of pharmacologic therapy is based on the severity of the disease, and the least amount of medications necessary to meet the goals of asthma therapy should be used.1,3 Stepwise therapy for the treatment of chronic asthma based on disease severity is shown in Table 11—1. [Pg.223]

Serafin WE. (1996). Drugs used in the treatment of asthma. In Goodman and Gilman s The Pharmacological Basis of Therapeutics, 9th ed. Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Goodman Gilman A, eds. New York McGraw-Hill. [Pg.463]

BASIC PHARMACOLOGY OF AGENTS USED IN THE TREATMENT OF ASTHMA... [Pg.429]

However, in individuals with increased intracranial pressure, asthma, chronic obstructive pulmonary disease, or cor pulmonale, this decrease in respiratory function may not be tolerated. Opioid-induced respiratory depression remains one of the most difficult clinical challenges in the treatment of severe pain. Research is ongoing to understand and develop analgesic agents and adjuncts that avoid this effect. Research to overcome this problem is focused on 5 receptor pharmacology and serotonin signaling pathways in the brainstem respiratory control centers. [Pg.692]

Disodium cromoglycate (724), marketed as Intal or Cromolyn Sodium, bears some structural resemblance to khellin (457), the spasmolytic component of seeds of Ammi visnaga. Intal is one of the more successful drugs for the prevention of asthmatic attacks, though it is not effective in the treatment of an acute attack of asthma. It appears to prevent the release of histamine and other substances which mediate hypersensitivity reactions but is ineffective once these substances have been released. The chemistry and pharmacology of Intal have been reviewed (B-70MI22402). [Pg.882]

The contraindications to the use of 6-blockers are asthma and other bronchospastic conditions, severe bradycardia, atrioventricular blockade, bradycardia-tachycardia syndrome, and severe unstable left ventricular failure. Potential complications include fatigue, impaired exercise tolerance, insomnia, unpleasant dreams, worsening of claudication, and erectile dysfunction. Katzung PHARMACOLOGY, 9e > Section III. Cardiovascular-Renal Drugs > Chapter 12. Vasodilators the Treatment of Angina Pectoris > ... [Pg.281]

Basic Pharmacology of Agents Used in the Treatment of Asthma... [Pg.470]


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See also in sourсe #XX -- [ Pg.253 ]




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