Aspirin cell growth

Goel, A., Chang, D.K., Ricciardiello, L., Gasche, C., and Boland, C.R., A novel mechanism for aspirin-mediated growth inhibition of human colon cancer cells, Clin. Cancer Res., 9, 383-390,... 

Kashfi et al. (2002) NO-NSAIDS Human pancreatic (PaCa-2), prostate (LNCap), lung (A549), colon (HT-29 and HCT-15) and tongue (SCC-25) cancers Cell growth curves Lowest IC50 1 p-M (NO aspirin) ... 

Elder, D.J.E., Hague, A., Hicks, D. J., and Paraskeva, C., Differential growth inhibition by the aspirin metabohte sahcylate in human colorectal tumor cell lines enhanced apoptosis in carcinoma and in v/rro-tiansformed adenoma relative to adenoma cell lines. Cancer Res., 56, ITIMine, 1996. 

A more frequent complication is restenosis of the angioplasty site which occurs in 25-30% of patients over 6-9 months " . Pathological studies in patients with recurrence of symptoms are infrequent but demonstrate proliferation of fibroblasts and vascular smooth muscle cells overlying and distinct from the traumatized atherosclerotic plaque . Similar lesions have been described in early atherosclerosis and there is evidence to suggest a role for platelets in the development of such lesions , possibly through release of platelet-derived growth factors which stimulate fibroblast and vascular smooth muscle proliferation . Thus, depletion or inhibition of platelets prevents the development of atherosclerosis in animal models and aspirin inhibits the accelerated coronary atherosclerosis which occurs in cardiac transplant recipients. Furthermore, restenosis is more frequent when there is evidence of a thrombus at the angioplasty site consistent with previous... 

Williams, J.L., Nath, N., Chen, J., Hundley, T.R., Gao, J., Kopelovich, L., Kashfi, K., and Rigas, B. (2003). Growth inhibition of human colon cancer cells by nitric oxide (no)-donating aspirin is associated with cyclooxygena.se-2 induction and beta-catenin/t-cell factor signahng, nuclear factor-kappab, and no synthase 2 inhibition Implications for chemoprevention. Cancer Res. 63, 7613-7618. 

Zhao, W, Mackenzie, G.G., Murray, O.T., Zhang, Z., and Rigas, B. (2009). Phosphoaspirin (Mdc-43), a novel benzyl ester of aspirin, inhibits the growth of human cancer cell lines more potently than aspirin A redox-dependent effect. Carcinogenesis 30, 512-519. 

Royle et al. (2004) NO-NSAIDS Human prostate (LNCap and PC-3) Cell viability (MTT) and apoptosis (TUNEL) <80% growth inhibition by NO aspirin (NCX 4060) and <90% apoptotic cells ... 

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