5-alpha-reductase inhibitors

Heinrich, M., H. Rimpler, and N. A. Barrera. Indigenous phytotherapy of gastrointestinal disorders in a lowland Mixe community (Oaxaca, Mexico) Ethnopharmacologic evaluation. J Ethnopharmacol 1992 36(1) 63—80. Liao, Z. K., J. Jiang, and X. P. Xu. The technical method for preparation of phytic acid and oryzenin. Huaxi Yaoxue Zazhi 1996 11(1) 46-70. Tokuyama, T. 5-Alpha-reductase inhibitor from rice for therapeutic use. Patent-Japan Kokai Tokkyo Koho-07 157,436 1993 7 pp. [Pg.413]

Geriatric Considerations - Summary Alpha-adrenergic blockers are modestly effective alone, and in combination with 5-alpha reductase inhibitors (e,g, finasteride) in the treatment of urinary obstructive symptoms related to benign prostatic hyperplasia. Alfuzosin is a "uroselective" alpha-blockerwhich appears to cause less orthostatic hypotension than nonselective alpha-blockers such as terazosin, prazosin, and doxazosin. [Pg.32]

The benefit of combining an alpha-adrenoceptor antagonist with a 5-alpha-reductase inhibitor has been assessed in men with benign prostatic hyperplasia (23). Modified-release alfuzosin was more effective than finasteride, with no additional benefit in combining the drugs. The adverse effects of alpha-blockade were postural hypotension, hypotension, headache, dizziness, and malaise the adverse effects of finasteride were ejaculatory disorders and impotence. [Pg.151]

Steiner JF. Finasteride a 5 alpha-reductase inhibitor. Clin Pharm 1993 12(l) 15-23. [Pg.156]

Reddy GK. Finasteride, a selective 5-alpha-reductase inhibitor, in the prevention and treatment of human prostate cancer. Clin Prostate Cancer 2004 2(4) 206-8. [Pg.156]

Gormley GJ, Stoner E, Rittmaster RS, Gregg H, Thompson DL, Lasseter KC, Vlasses PH, Stein EA. Effects of finasteride (MK-906), a 5 alpha-reductase inhibitor, on circulating androgens in male volunteers. J Clin Endocrinol Metab 1990 70(4) 1136-41. [Pg.157]

Katashima, M., Yamamoto, K., Tokuma, Y., Hata, T., Sawada, Y., and Iga, T., Pharmacokinetic and pharmacodynamic study of a new nonsteroidal 5 alpha-reductase inhibitor, 4-[3-[3-[Bis (4-isobutylphenyl)methylamino]benzoyl]-lH-indol-l-yl]-butyric acid, in rats, Journal of Pharmacoloqy and Experimental Therapeutics, Vol. 284, No. 3, 1998, pp. 914-920. [Pg.418]

Testosterone-5-alpha reductase inhibitors (finasteride, dutasteride)... [Pg.483]

A systematic review and meta-analysis of randomized trials of S. repens in men with benign prostatic hyperplasia showed that saw palmetto extracts improve urinary symptoms and flow measures to a greater extent than placebo, and similar improvements in urinary symptoms and flow measures to the 5-alpha-reductase inhibitor finasteride with fewer adverse effects (6). [Pg.336]

Category 5-alpha reductase inhibitor Androgen antagonist Half-life 3-5 weeks... [Pg.201]

A recent study by Bach, Schmitt, and Ebeling compared three prescriptive medications with a standardized saw palmetto extract. The drugs worked by two different mechanisms. Finasteride is a synthetic 5-alpha-reductase inhibitor, and the other two drugs, terazosin and alfuzosin, are alpha-1 blockers. In all important parameters, the saw palmetto was a comparable treatment with far fewer side effects. It decreased residual urine volume, reduced irritation, and increased urinary flow 80 percent of patients rated their improved quality of life as good to very good. [Pg.71]

P. O. Gisleskog, D. Hermann, M. Hammarlund-Udenaes, and M. O. Karlsson, A model for the turnover of dihydrotestosterone in the presence of the irreversible 5 alpha-reductase inhibitors Gil98745 and finasteride. Clin Pharmacol Ther 64 636-647 (1998). M. Pirmohamed and B. K. Park, in Elandbook of Drug Metabolism, T.F. Woolf (Ed.). Marcel Dekker, New York, 1999, pp. 443 76. [Pg.627]

Alpha reductase inhibitor, preventing conversion of testosterone dihydrotestosterone (DHT)... [Pg.290]

The client diagnosed with mild benign prostatic hypertrophy (BPH) is prescribed the 5-alpha-reductase inhibitor finasteride (Proscar) to relieve symptoms of urinary frequency. Which intervention should the clinic nurse implement ... [Pg.172]

Finasteride (Proscar), a 5-alpha-reductase inhibitor, and digoxin (Lanoxin), a cardiac glycoside. [Pg.173]

The 5-alpha-reductase inhibitors work by reducing the size of the prostate gland, resulting in a relief of the obstructive symptoms of urgency, frequency, difficulty initiating a urine stream, and nocturia. [Pg.184]

Althongh no substantial evidence to date is available, many sources suggest the combination of lycopene with a plethora of 5-alpha-reductase inhibitors such as saw palmetto, riboflavin, zinc, and selenomethionine for the protection or therapy of prostate cancer. Despite the present fragmentary nnderstanding, it is likely that novel nseful... [Pg.637]

The use of finasteride and other 5-alpha reductase inhibitors in benign prostatic hyperplasia has been associated with adverse sexual outcomes, including dysfunction of erection or ejaculation and... [Pg.873]

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