Aspirin prevention

CYP5 synthesizes thromboxane A2, a fatty acid in the arachidonic acid cascade that causes platelet aggregation. Aspirin prevents platelet aggregation because it blocks the cyclooxygenases COX1 and COX2 which catalyze the initial step of the biotransformation of arachidonic acid to thromboxane and prostaglandins. 

So ephedrine releases norepinephrine, and aspirin prevents the release from being turned off. 

Based on several randomized trials, aspirin has become the preferred antiplatelet agent in the treatment of aU ACSs. Early aspirin administration to all patients without contraindications within the first 24 hours of hospital admission is a quality care indicator (see Table 16-3). The antiplatelet effects of aspirin are mediated by inhibiting the synthesis of thromboxane A2 through an irreversible inhibition of platelet cyclooxygenase-1. Following the administration of a non-enteric-coated formulation, aspirin rapidly (<10 minutes) inhibits thromboxane A2 production in the platelets. Aspirin also has anti-inflammatory actions, which decrease C-reactive protein and also may contribute to its effectiveness in ACS. In patients undergoing PCI, aspirin prevents acute thrombotic occlusion during the procedure. 

FIGURE 14 Aspirin prevents platelet aggregation and may be helpful in the treatment of thromboembolic disease. 

Chapter 26 discusses the chemistry of hpids. Lipids are water-insoluble compounds found in animals and plants. You will first study the stmcture and function of different kinds of lipids. You will then be able to understand such things as how aspirin prevents inflammation and what causes butter to become rancid. How cholesterol and other ter-penes are synthesized in nature will be explained as well. 

Aspirin prevents heart attacks by minimizing the formation of biood ciots in the coronary arteries. The photograph shows such a biood ciot (orange) in the left main puimonary artery of a patient. 

Ouyang, N., Williams, J.L., Tsioulias, GJ., Gao, J., latropoulos, M.J., Kopelovich, L., Kashii, K., and Rigas, B. (2006). Nitric oxide-donating aspirin prevents pancreatic cancer in a hamster tumor model. Cancer Res. 66,4503—4511. 

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