Aryl hydrocarbon receptor nuclear translocator

Marcus, R., Holsapple, M., and Kaminski, N., Lipopolysaccharide activation of murine splenocytes and splenic B cells increased the expression of aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator, J. Pharmacol. Exper. Therap.. 287, 1113, 1998. 

Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the expression of cytochrome P450 lAl, the aryl hydrocarbon receptor, and the aryl hydrocarbon receptor nuclear translocator in rat brain and pituitary. Toxicol Appl Pharmacol 169 159-167. 

Choi H, Chun YS, Kim SW, Kim MS, Park JW. 2006. Curcumin inhibits hypoxia-inducible factor-1 by degrading aryl hydrocarbon receptor nuclear translocator A mechanism of tumor growth inhibition. Mol Pharmacol 70 1664-1671. 

Abbott BD, Probst MR. 1995. Developmental expression of two members of a new class of transcription factors II. Expression of aryl hydrocarbon receptor nuclear translocator in the C57BL/6N mouse embryo. Develop Dynam 204 144-155... 

Hirose K, Morita M, Ema M, et al. 1996. cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Amt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Amt). Mol Cell Biol 16 1706-1713. 

Pollenz RS, Sattler CA, Poland A. 1994. The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa lclc7 cells by immunofluorescence microscopy. Mol Pharmacol 45 428-438. 

Scheel J, Hussong R, Schrenk D, Schmitz HJ. Variability of the human aryl hydrocarbon receptor nuclear translocator (ARNT) gene. J Hum Genet 2002 47 217-224. 

Both a and P subunits of HIF are basic helix-loop-helix PAS proteins (bHLH-PAS) (6, 7), as observed in other transcription-factor proteins (Fig. 2). The short, basic region of bHLH-PAS proteins is directly responsible for DNA binding, and the adjacent helix-loop-helix domain allows dimerization of the two HIF subunits after translocation of HIF-a to the nucleus. The PAS domain [PAS-A/PAS-B/PAC PAS PER (periodic circadian protein), aryl hydrocarbon receptor nuclear translocator (ARNT), single-minded protein (SIM) (7) PAC motif C-terminal to PAS motifs) is involved in more specific interactions between the two subunits (for review see Reference 8). It is proposed that the specific interaction between the HIF-a and HIF-P subunits promotes folding and dimerization of the bHLH region that enables subsequent DNA binding (8). HIF-a is a Class 1 bHLH-PAS protein, which means that it can homodimer-ize and heterodimerize HIF-3 (also known as ARNT, which is... 

Hur E, Kim HH, Choi SM, Kim JH, Yim S, Kwon HJ, Choi Y, Kim DK, Lee MO, Park H. Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-lalpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol. Mol. Pharmacol. 2002 62 975-982. 

Hord NG, Perdew GH. 1994. Physio-chemical and immunochemical analysis of aryl hydrocarbon receptor nuclear translocator characterization oftwo monoclonal antibodies to the aryl hydrocarbon receptor nuclear translocator. Molec. Pharmacol. 46 618-24... 

Probst MR, Reisz-Porszasz S, Agbunag RV, Ong MS, Hankinson O. 1993. Role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon (dioxin) receptor action. Molec. Pharmacol. 44 511-18... 

Holmes JL, Pollenz RS. 1997. Determination of aryl hydrocarbon receptor nuclear translocator protein concentration and subcellular localization in hepatic and nonhepatic cell culture lines development of quantitative Western blotting protocols for calculation of aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein in total cell lysates. Molec. Pharmacol. 52 202-11... 

Rowlands, J.C., I.L. McEwan and J.A. Gustafsson. Trans-activation by the human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins direct interactions with basal transcription factors. Mol. Pharmacol. 50 538—548, 1996. 

Carney, S.A., W. Heideman and R.E. Peterson. 2,3,7,8-Tetrachlorodibenzo-p-dioxin activation of the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator pathway causes developmental toxicity through a CYPlA-independent mechanism in zebrafish. Mol. Pharmacol 66 512-521, 2004. 

Necela, B. and R.S. Pollenz. Functional analysis of activation and repression domains of the rainbow trout aryl hydrocarbon receptor nuclear translocator (RtARNT) protein isoforms. Biochem. Pharmacol. 57 1177-1190, 1999. 

Powell-Coffman, J.A., C.A. Bradfield and W.B. Wood. Caenorhabditis elegans orthologs of the aryl hydrocarbon receptor and its heterodimerization partner the aryl hydrocarbon receptor nuclear translocator. 

Sojka, K.M. and R.S. Pollenz. Expression of aryl hydrocarbon receptor nuclear translocator (ARNT) isoforms in juvenile and adult rainbow trout tissues. Mar. Biotechnol. 3 416-427, 2001. 

ARNT Aryl hydrocarbon receptor nuclear translocator... 

Ruegg J, Swedenborg E, Wahlstrom D, Escande A, Balaguer P, Pettersson K, Pongratz I (2008) The transcription factor aryl hydrocarbon receptor nuclear translocator functions as an estrogen receptor beta-selective coactivator, and its recruitment to alternative pathways mediates antiestrogenic effects of dioxin. Mol Endocrinol 22 304—316... 

Ma Q. Induction and superinduction of 2,3,7,8-tetrachlorodibenzo-rho-dioxininducible poly(ADP-ribose) polymerase Role of the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator transcription activation domains and a labile transcription repressor. Arch Biochem Biophys 2002 404(2) 309-16. 

AhRR, which significantly enhances the SUMOylation of both proteins. SUMOylated AhRR recruits corepressors ANKRA2, HDAC4, and HDAC5 to form the transcriptional repressor complex. AhRR AhR repressor, ARNT aryl hydrocarbon receptor nuclear translocator... 

In U937 cells and human macrophages aryl hydrocarbon receptor, with its partner cofactor aryl hydrocarbon receptor nuclear translocator, was expressed and CYPlAl mRNA expression was induced in the presence of aryl hydrocarbon receptor ligand 3-methylcholanthrene (Komura et al. 2001). 

As described above, PYP is part of a family of proteins named Xanthopsins, which thus far have only been identified in proteobacteria. Nevertheless, PYP also shows striking similarities to the much larger family of PAS domains. These PAS domains were identified in proteins from all three kingdoms of fife, i.e., in the Bacteria, the Archaea, and the Eucarya. PAS is an acronym formed from the names of the proteins in which the PAS motive was first recognized the Drosophila period clock protein (PER), the vertebrate aryl hydrocarbon receptor nuclear translocator (ARNT), and the Drosophila single-minded protein (SIM). 

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