Arterial tissues

Eckert B, Koch C, Thomalla G, Roether J, Zeumer H. Acute basilar artery occlusion treated with combined intravenous Abciximab and intra-arterial tissue plasminogen activator report of 3 cases. Stroke 2002 33 1424-1427. 

HOCl-mediated protein oxidation accelerates under pathophysiological conditions. Thus, proteins from extracellular matrix obtained from advanced human atherosclerotic lesions contained the enhanced levels of oxidized amino acids (DOPA and dityrosine) compared to healthy arterial tissue [44], It was also found that superoxide enhanced the prooxidant effect of hypochlorite in protein oxidation supposedly by the decomposition of chloramines and chlor-amides forming nitrogen-centered free radicals and increasing protein fragmentation [45], In addition to chlorination, hypochlorite is able to oxidize proteins. The most readily oxidized amino acid residue of protein is methionine. Methionine is reversibly oxidized by many oxidants including hypochlorite to methionine sulfide and irreversibly to methionine sulfone [46] ... 

The accumulation of apo(a) in the aorta wall and in saphenous vein bypass grafts in relation to Lp(a) levels was recently demonstrated (C14, R3). Subsequently, the preferential deposition of extracellular apo(a) in atherosclerotic lesions of aortic and coronary artery tissue, in conjunction with the intracellular localization of apo(a) in macrophage-derived foam cells, has been the focus of a number of studies (N6, P7, S34, S35, W17). These careful studies also demonstrated the avid binding of Lp(a) to extracellular matrix components and the colocalization of fibrin and apo(a) in atheromatous lesions (N8, W16). 

Carr and co-workers32 have found that the ATPase activity of arterial tissue in dogs varied as indicated in Table 12. 

Dayton, S., Hashimoto, S., and Pearce, M. L. (1965). Influence of a diet high in unsaturated fat upon composition of arterial tissue and atheromata in man. Circulation 32, 911-924. 

In summary, the consumption of garlic appears to reduce serum cholesterol in experimental animals in a dose-dependent fashion. This may be due to decreased synthesis or increased excretion of cholesterol through the intestinal tract. It has been reported that garlic consumption increases high-density lipoprotein (HDL) levels, which may help to remove excess cholesterol from arterial tissue. 

The simplest answer is ease of administration. More importantly, there are several limitations to local delivery of drugs in the form of DES. The efficacy of these new devices depends on several variables, including the selection of an effective drug, its solubility, diffusion characteristics, release kinetics, arterial tissue concentration, retention, and whether the platform is polymer based or nonpolymeric. Local delivery of the drug in this manner may delay rather than prevent neointima. This is supported by preclinical studies that show impaired healing and neointimal catch-up (4). There is concern that neointimal growth will accelerate in response to the... 

The intravascular catheter, used on a routine basis to image arterial tissue, is an essential medical tool enabling the surgeon to identify disease type and to take appropriate steps to combat it, and the demand is for very large numbers (currently approximately 175000 p.a.). 

When the metabolic turnover of elastin in arterial tissue or in lung is examined, it is extremely difficult to demonstrate active turnover. Once an elastin fiber is formed it appears to be fixed. The turnover of rat aorta elastin is best measured in years (8). Data shown in Figure 5 also suggests negliable turnover. The animal used for this study, the Japanese quail, was chosen because it fully matures at 5-6 weeks of age. Similar to the rat its elastin appears to turn over in amounts best estimated in years. 

Arterial tissue, transhydrogenase in, 65 Ascites cells, glyoeraldehyde-3-phos-phate dehydrogenase in, 47 Ascorbate, cytochrome c peroxidase and, 353... 

D15. Dyrbye, M. O., The acid mucopolysaccharides in human arterial tissue. Acta Chem. Scand. 13, 2119-2120 (1959). 

Injury to a tissue results in exposure of tissue factor from the tom blood vessel. Within the wall of the artery, tissue factor occurs in the adventitia, and not in the... 

Schnitzer, J.J., et al. Absolute quantitative autoradiography of low concentrations of 1251-labeled proteins in arterial tissue. Journal of Histochemistry and Cytochemistry, 1987, 35(12), 1439-1450. 

The determination of cerebral perfusion using CTP is based on examining the relationships between the arterial, tissue, and the venous enhancement. More specifically, tracer kinetic theory states that if one knows the input and the output of a tracer from a voxel, one can determine the volume of distribution (i.e., fractional vascular volume) and the clearance rate (i.e., flow per unit tissue volume) [20, 114, 115]. The fractional vascular volume,/, is defined by the following equation ... 

H25. Hodara, M., Figura, K. von. Filipovic, I., and Buddecke, E., Studies on the chemistry of arterial wall. XVI. Topochemical studies on the glycosamino-glycan and lipid metabolism in bovine arterial tissue. HoppeSeylet s Z. Physiol. Chem. 354, 445-452 (1973). 

K26. Kirk J. E., and Dyrbye, M., Mucopolysaccharides of human arterial tissue. II. Analysis of total isolated mucopolysaccharide material. J. Gerontol. 12, 23-31 (1957). 

Morazzoni, P. and Magistretti, M.J. 1986. Effects of Vaccinium myrtillus anthocyanosides on prostacyclin-like activity in rat arterial tissue. Fitoterapia 57, 11-14. 

The author of this book has had considerable experience with the ATR technique and finds it particularly useful for work with biological specimens. The optical properties of tissues are such that they must be very thinly sectioned to obtain transmission spectra, whereas the ATR method does not depend on sample thickness. Useful spectra have been recorded from normal and diseased human arterial tissue (Fig. 3.25) and heart tissue (chicken, rat, calf) (Parker and Ans, 1967). Examinations... 

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