Aristol

Aristolic acid, CigHuO N, crystallises in orange-red needles, m.p. 260-270°, and, like the two foregoing alkaloids, gives a green solution with concentrated sulphuric acid. 

Reduction of aristolochic acid I with NaBH4 was investigated by Ito et al. They found that aristolochic acid I was reduced to 9,10-dihydroaristolochic acid I (69) at room temperature (85% yield), and they also isolated a nitrogen-free product, aristolic acid (70) (Scheme 8) (5% yield). When this reaction takes place at 90-100°C for 3 hr, however, the main product obtained was aristolic acid. Decarboxylation of 9,10-dihydroaristolochic acid I with copper powder in... 

In addition, intraamniotic injection of aristolochic acid I in mid-term pregnant dogs and rats led to termination of pregnancy (106). Later, Che et al. reported that four Aristolochia alkaloids, aristolochic acid I and its methyl ester, aristolic acid, and (125)-7,12-secoish-waran-12-ol were ineffective in antifertility tests, when administered to mice, hamsters, or rats (707). 

Iodine is used in various forms in medicine—e.g. tincture of iodine, liquor iodi, iodized cotton, iodized wine, iodized water, oils and syrups iodides of potassium, mercury, iron, arsenic, lead, etc. and as methyl iodide or di-iodide iodoform, CHI3 ethyl iodide, C2H5I iodole, C4I4.NH aristole etc.—largely for external application as an antiseptic. Some iodides are used in photography, and in analytical operations and a considerable amount of iodine is used in the preparation of aniline dyes. 

Thymol (thymic acid) is extracted from essence of thyme. It is four times more bactericidal than phenol and ten times less toxic. Thymol iodide is used on burns in the same way as iodoform, but has the advantage of not being absorbed and not having any odor. It is less irritating on wounds and mucous membranes than dithymol diiodide or aristol. Thymol iodide powder, an antiseptic that is used often after a phenol peel, physically alters the selective permeability of plasma membranes. It is nevertheless a protoplasmic poison that denatures enzyme proteins and is also an allergen. 

Aristol. [Pilot] Substituted C20-24 benzene lubricant lube oil additive chemical feedstock for sulfonation to produce emulsifiers and corrosion preventatives. 

Iodination of phenols that have free ortho- and / ara-positions, in an alkaline medium, by iodine, leads not only to the desired iodo derivatives, but also to reddish-brown polymeric by-products, e.g., Lautemann s Red from phenol462,463 and aristol from thymol.464 These unpleasant side reactions are reduced by working in methanolic alkali465 or in concentrated aqueous or methanolic ammonia.466 A nearly quantitative yield of 2,4,6-triiodophenol is obtained by slowly adding a concentrated solution of I2 in KI to phenol in concentrated aqueous ammonia.467... 

H OCHj H och3 6-Methoxy aristolic acid (56) A. kwangsiensis A. versicolor 247 222... 

This acid induced impairment of development and reconciled with decreases found in uterine weight and its total protein contents. It prevented specific uterine alkaline phosphatase activity. On the otherhand, specific uterine acid phosphatase activity remained low on days 4 and 5 and increased significantly thereafter. It indicated that aristolic acid interferes with steroidal conditioning of the uterus and renders it hostile to ovum implantation. 

Methyl ester of aristolic acid (55) isolated from A. indica exerted 100%, 25% and 20 % abortifacient activity in mice when administered at the dose level of 60 mg/kg body weight on days 6 or 7, 10 and 12 post coitum, respectively [88]. 

Lajide et al. examined the antifeedeant activity of the metabolites of A. albida root extracts, aristolic acid (51), aristolochic acid (5), 6-hydroxy-... 

Aristol is a compound of thymol and iodin, properly belonging among the dibenzenio compounds, produced by the action of a solution of I in KI upon an aqueous solution of thymol in the presence of KHO. It is an inodorous, yellowish red jjowder, in-.soluble in HsO, very sparingly soluble in alcohol, readily soluble in ether and in chloroform. It is decomposed by heat and by light and is said to be a non-poisonous antiseptic. 

Methyl alcohol — Ethyl alcohol — Propyl alcohol — Butyl alcohol—(Iodoform, Chloroform, Bromoform). [Aristol,... 

Chloroform and Bromoform are formed if the chloride or bromide of the alkalies is used (comp. Elbs and Herz, who deny this ). Analogous to these substitution reactions is the formation of aristol, a di-thymol-di-iodide, as made by Messinger and Vortmann, by the electrolysis of thymol with the addition of potassium iodide. Similar to this also is the preparation of nosophene, a tetra-iodo-phenol-phthalein (Classen and L6b ). 

When aristolochic acid-I is reduced under usual conditions (for example LiAlH4/THF, reflux for 2 h), aristololactam-I is formed. However, if this alkaloid is dissolved in 1% aq. ammonia and NaBH4 is added, aristolochic acid-I loses its nitro moiety, and aristolic acid is obtained in more than 90% yield [4]. 

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