Thymol iodide

Other lodo Compounds. Thymol iodide, C2OH24I2O2, mol wt 550.23, 46.13% I, is a reddish brown or reddish yeUow bulky powder that... 

Jod-saure, /, iodic acid, -schwefel, m. sulfur iodide, -serum, n. iodized serum, -silber, n. silver iodide, -silizium, n. silicon iodide. -stSrke, /. starch iodide, iodized starch. -stSrkepapier, n. starch iodide paper, -stick-stoff, m. nitrogen iodide, -thymol, n.iPhaTm.) thymol iodide, -tinktur,/. tincture of iodine, -toluol, n. iodotoluene. -iibertrilger, m. iodine carrier. 

Thymol (thymic acid) is extracted from essence of thyme. It is four times more bactericidal than phenol and ten times less toxic. Thymol iodide is used on burns in the same way as iodoform, but has the advantage of not being absorbed and not having any odor. It is less irritating on wounds and mucous membranes than dithymol diiodide or aristol. Thymol iodide powder, an antiseptic that is used often after a phenol peel, physically alters the selective permeability of plasma membranes. It is nevertheless a protoplasmic poison that denatures enzyme proteins and is also an allergen. 

Treatment is aggressive and requires hospitalization. Patients should be taken to hospital as soon as there is any suspicion of toxic shock (raised temperature) and before any other symptoms appear. The symptoms of infection are often hard to spot there was no visible sign of infection beneath the thymol iodide powder before the start of toxic shock described in the 1980s after a phenol peel (Baker s solution). Toxic shock syndrome can come like a bolt from the blue. In the cases described, the skin recovered normally and no scars were left after recovery. 

It is difficult to diagnose and impossible to monitor herpes outbreaks, large or small, beneath an opaque occlusive mask of bismuth subgallate or thymol iodide. If there is any hint of herpes, any acute pain between the 4th and 7th day after the phenol, the powder mask" should be removed immediately in order to examine the skin thoroughly. If the doctor s suspicions are confirmed, the herpes should be treated as described above. Once the diagnosis has been made, the powder mask should not be replaced, and the moist technique should be used instead, with regular application of an antibiotic cream (e.g. bacitracin) to avoid secondary bacterial infection. 

Using a bismuth subgaUate or thymol iodide powder mask. 

Styrene (99%, Nacalai Tesque, Japan), MMA (99%, Nacalai), and azobis(isobutyronitrile) (AIBN) (99%, Nacalai) were purified by distillation or recrystallization. 1-Phenylethyl iodide (PE-1) and 2-cyanopropyl iodide (CP-1) were prepared according to Matyjaszewski (9) and Balczewski (10), respectively. 2,2 -Azobis(2,4,4-trimethylpentane) (VRllO) (99.9%, Wako Pure Chemical, Japan), f-butyl peibenzoate (BPB) (98%, Aldrich), di(4-f-butylcyclohexyl) peroxydicarbonate (PERKADOX16) (95%, Akzo), thymol iodide (TI) (95%, Wako), 2,4,6-trimethyl phenol (2,4,6-Me) (97%, Wako), 2,6-di-f-butyl-4-methyl phenol (3,5-di-f-butyl-4-hydroxy toluene (BUT)) (98%, Wako), 2,6-di-i-butyl-4-methoxy phenol (3,5-di-i-butyl-4-hydroxy anisole (BHA)) (97%, Aldrich), phenol (99%, Wako), vitamin E (VE) (99.5%, Wako), vitamin C (VC) (99%, Tokyo Kasei, Japan), and 2,2,6,6-tetramethylpiperidinyl-l-oxy (TEMPO) (99%, Aldrich) were used as received. 

We first examined thymol iodide (Tl) (Figure 1), a phenoxy iodide, as a catalyst (deactivator 1-A). Tl is commercially available and used as a medicine, and thymol (with an OH group instead of an 01 group) is a scent component of thyme. We examined the polymerization of styrene at 100 °C, using PE-I (Figure 1) as a low-mass alkyl iodide (dormant species), VRllO as a conventional radical initiator (an azo initiator), and Tl as a catalyst In this polymerization (Scheme lb). Polymer, which is originally supplied by VRl 10, is supposed to react with Tl (R-OI), in situ producing the activator radical, the thymoxy radical (R-0 ) (and Polymer-I). If R-0 effectively abstracts I from PE-... 

Figure 8.3 African-American with truncal congenital Becker nevus treated with one formula (Stone II 60% phenol, 0.2% croton oil) over twelve test patches, six In each of two rows. (A) Immediately after peel applications (from left to right) of 1, 5, 10, 20, 50, and 100 rubs (B) top row covered with waterproof tape, bottom row covered with Aquaphor ointment (C) at 48 hours tape removed, thymol Iodide powder applied. Threshold effect between 10 and 20 rubs seen at 10 days (D) and 73 days (E) post peel...

Caucasian, mild rhytids 2 min/zone using one dip of large swab 1 min added to deeper rhytids using one dip of large swab Thymol iodide powder at 24 hr for 6 days or immediate Aquaphor ointment until healed... 

Caucasian, moderate rhytids and dyschromia 1 min/zone for analgesic effect 4 min on top of Stone VK, using two dips of large swabs Immediate tape for 48 hr. Thymol iodide powder for 6-7 days... 

Allow to dry for 24 hours then apply thymol iodide powder for a less deep peel. In the author s opinion... 

End treatment Aquaphor ointment. Keep moist with ointment until healed - may wash gently and shower Blot dry with gauze Apply thymol iodide powder in 24 hr for 8 days or apply Aquaphor ointment immediately Let dry, gauze sponge away oils to further dry (1 min). Apply 2-3 layers of waterproof tape, Kling (Johnson Johnson, New Brunswick, NJ) Coban (3M Health Care Products, St, Paul, Minn). Spandage (Meditech International, Brooklyn, NY) for 48 hr to hold tape. 

The exudate excess is gently removed with swabs and gauze but no attempt is made to remove all. Thymol iodide powder is appHed with large rectal swabs in a roUing fashion. The patient is supplied with powder and... 

Figure 8.17 Poor thymol iodide mask. Notice peeling of the mask at day 4 of powder (day 6 of peel) with pink epithelium showing...

Figure 8.18 Peeling of thymol Iodide mask after treatment with warm compresses of mineral oil and vitamin A D ointment. Notice pink, smooth epithelium at day 9 post peel...

The patient shown in Figure 8.21 is a Caucasian with Fitzpatrick II skin type who was treated with a 5-minute Stone II peel followed by thymol iodide powder at 24 hours until healed at 1 week (see Fig. 8.21D). This was before it was realized that the Stone VK was definitely less painful to apply than the Stone II. The same result could have been expected with a 5-minute Stone VK. 

A) Pre 5-minute Stone VK and 2-minute Stone II (B) 12 months post peel treated with wateiproot tape and thymol iodide powder... 

The patient shown in Figure 8.22, a Caucasian with Fitzpatrick skin type III, was treated with a 1-minute Stone II peel followed by waterproof tape occlusion for 48 hours and 3-day blending resorcinol peel to neck. (The face was treated with Aquaphor ointment after tape removal, as was the neck after the 3rd day of five coats of resorcinol - one every 5 minutes for five coats on three consecutive days. The resorcinol is put on like glycolic acid, one even coat every 5 minutes for five coats and repeated 3 days in a row. On the 3rd day after the five coats of resorcinol have dried, either thymol iodide powder is applied to form a crust or Aquaphor ointment is applied throughout healing. Either occlusion method works well. 

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