Neuronal stem cells, apoptosis

Dysbindin-2B has been identified as both stem cell factor apoptosis response protein 1 (SCF ARP1) by Lucas et al. (2005) and as a casein kinase 1 binding partner (CK1BP) by Yin et al. (2006). SCF ARP1 is expressed in bone marrow-derived myelomonocytic stem cells upon induction of apoptosis by withdrawal of stem cell growth factor SCF (Lucas et al., 2005). Programmed cell death via apoptosis controls stem cell numbers during hematopoietic cell development (Domen 2001). Since apoptosis is similarly important in development of neurons (Kuan et al., 2000 Buss and Oppenheim, 2004), dysbindin-2B may play a role in nervous system development (see also Section 2.2.33.1). 

Bosnjak ZJ, Yan Y, Canfield S, Muravyeva MY, Kikuchi C, Wells CW, Corbett JA, Bai X (2012) Ketamine induces toxicity in human neurons differentiated from embryonic stem cells via mitochondrial apoptosis pathway. Curr Drug Saf 7(2)406-119... 

First report to describe that naturally occurring biflavonoids regulate apoptosis and neuronal differentiation in pluripotent stem cells. ... 

Dasari VR, Veeravalh KK, Tsung AJ, Gondi CS, Gujrati M, Dinh D, Rao JS (2009) Neuronal apoptosis inhibited by cord blood stem cells after spinal cord injury. J Neurotrauma 26 May 2009 [Epub ahead of print]... 

Borgne A and Golsteyn RM (2003) The role of cyclin-depen-dent kinases in apoptosis. Prog Cell Cycle Res 5 453-459 Boyer LA et al (2005) Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122 947-956 Brazelton TR et al (2000) From marrow to brain expression of neuronal phenotypes in adult mice. Science 290 1775-1779... 

Salto K, Dubreuil V, Aral X et al. Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis. Proc Natl Acad Sci USA. 2009 106(20) 8350-8355. Funfschilling U, Saher G, Xiao L, Mobius W, Nave KA. Survival of adult neurons lacking cholesterol synthesis in vivo. BMC Neurosci. 2007 8 1. 

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