Antitumor substance

Stereostructure and synthesis of aplyronine A (macrolide with 24-member lactone ring), an antitumor substance of marine origin 96YGK1077. 

OS 118 Kawai, K., K. Sugawara, and T. Morin-gag. Antitumor substance. Patent-Eur... 

Isolation of Antitumor Substance from Basidiomycete Fungus Agaricus blazei and its Mechanism [5]. 

Nakajima H, Sato B, Fujita T, Takase S, Terano H, Okuhara M (1996) New Antitumor Substances, FR901463, FR901464 and FR901465 I. Taxonomy, Fermentation, Isolation, Physico-Chemical Properties and Biological Activities. J Antibiot 49 1196... 

A particular application of membrane bioreactors, patented in 2005 [20], concerns the production of an antitumor substance (paclitaxel). Since a full synthesis of paclitaxel is not possible due to its low yield, a semisynthesis of 10-deacetyl-baccatin... 

Takahashi, A., Kurosawa, S., Ikeda, D., Okami, Y., and Takeuchi, T., Altemicidin, a new acaricidal an antitumor substance. I. Taxonomy, fermentation, isolation, and physico-chemical and biological properties, J. Antibiot., 42, 1556, 1989. 

Fused pyrimidines inhibiting enzymes active in metabolism of folic acid as new antitumor substances 91KFZ(9)20. 

In the studies toward the total s)mthesis of the antitumor substance maytansine... 

On the other hand, Cylindrocarpon radicicola and Streptomyces lavendulae transform progesterone (22) into the antitumor substance testolactone (25) in 85% overall yield408. In this case, the reaction sequence is characterized by initial A -dehydrogenation. 

Problem 23.27 Treatment of ethyl acetoacetate with NaOEt (2 equiv) and BrCHgCH2Br forms compound X. This reaction is the first step in the synthesis of illudin-S, an antitumor substance isolated from the jack-o -lantern, a poisonous, saffron-colored mushroom. What is the stmcture of X ... 

Fr. 1 and Fr. 2 prolonged survival time and increased the survival rate compared to untreated tumor-removed mice Fig. (16) . Xanthoangelol and 4-hydroxyderricn were isolated from the Fr. 1 and Fr. 2, respectively, as antitumor substances Fig. (17) . 

The interaction of biologically active molecules like dyes with nucleic acids is of great interest because such molecules are used as drugs in chemotherapy (e.g. antibiotics, antitumor substances) other ones can induce mutations and tumors. They form intermolecular complexes with nucleic acids. A special class are dyes interacting with DNA by intercalation. These dye molecules are inserted between two base pairs (Fig. 10). A peculiarity of such complexes are base-sequence-dependent effects, for example, the fluorescence behaviour or the energy transfer inside the complex. These processes can depend on the type of base pairs between which the dye molecules are inserted. The quantum yield of fluorescence for some dyes after intercalation is much higher in AT-AT than in AT-GC or GC-GC sequences. 

H. Nakajima, B. Sato, T. Fujita, S. Takase, H. Terano, M. Okuhara, New antitumor substances, FR901463, FR901464 and FR901465. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities, /. Antibiot. 49 (1996) 1196. 

Kigoshi, H., Ojika, M., Suenaga, K., Mutou, T., Hirano, J., Sakakura, A., Ogawa, T., Nishiwaki, M., and Yamada, K., Synthetic studies on aplyronine A, a potent antitumor substance of marine origin. Stereocontrolled synthesis of the C21-C34 segment. Tetrahedron Lett., 35, 1247. 1994. 

Discovery Pladienolides are 12-membered macrohdes isolated as an antitumor substance by cell-based hypoxia-induced gene expression assay from Streptomyces platensis Mer-11107 [1]. The structures of pladienolide B and D were determined as 1 and 2, respectively [2,3]. Total synthesis of pladienolide B [4] and biosynthetic gene cluster [5] is also reported. 

Discovery Spliceostatin A (1) is a methyl ketal derivative of FR901464 (2), which was isolated as an antitumor substance from the culture broth of bacterium Pseudomonas sp. No. 2663 [1,2]. The structure of FR901464 was determined to be compound 2 on the basis of spectroscopic and chemical evidence [3]. Total syntheses of FR901464 were reported 4-6. 

Nakajima, H., Hori, Y., Terano, H., et al. (1996). New antitumor substances, FR901463, FR901464 and FR901465 11. Activities against experimental tumors in mice and mechanism of action. J. Antibiot, 49, 1204. 

Yamada, K., Ojika, M., Ishigaki, T., Yoshida, Y, Ekimoto, H., and Arakawa, M. (1993). Aplyro-nine A, a potent antitumor substance, and the congeners aplyronines B and C isolated from the sea hare Aplysia kurodai. J. Am. Chem. Soc. 115, 11020-11021. 

Sarkomycin. Sarcomycin. Antibiotic and antitumor substance produced by Sireptomyces trythroehromo-genes, strain W -115-C, from soil found at Kamakura, Japan Umezawa al.. J. Antibiot. 6A, 101, 147, 153 (1953) eidem, t.Urbior. Chemother, , 514 (1954). Structure of sarkomycin A. the active principle Hooper et at., ibid. 5, 585 (1955). Characterization of sarkomycins A, A and B Maeda,... 

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