Hypoxia-inducible gene expression

Gracey, A.Y., J.V. Troll and G.N. Somero (2001). Hypoxia-induced gene expression profiling in the euroxic fish Gillichthys mirabilis. Proc. Natl. Acad. Sci. USA, 98 1993-1998. 

Liu Q, Berchner-Pfannschmidt U, Moller U, Brecht M, Wotzlaw C, et al. 2004. A Fenton reaction at the endoplasmic reticulum is involved in the redox control of hypoxia-inducible gene expression. Proc Natl Acad Sci USA 101 4302-4307. 

Discovery Pladienolides are 12-membered macrohdes isolated as an antitumor substance by cell-based hypoxia-induced gene expression assay from Streptomyces platensis Mer-11107 [1]. The structures of pladienolide B and D were determined as 1 and 2, respectively [2,3]. Total synthesis of pladienolide B [4] and biosynthetic gene cluster [5] is also reported. 

Metzen E, Fandrey J, Jelkmatm W. Evidence against a major role for Ca in hypoxia-induced gene expression in human hepatoma cells (Hep3B). J Physiol (Lond) 1999 517(Pt 3) 651-657. 

Solomon IC, Edelman NH, Neubauer JA. Pre-Botzinger complex functions as a central hypoxia chemosensor for respiration in vivo. J Neurophysiol 2000 83 2854—2868. Lipton AJ, Johnson MA, Macdonald T, Lieberman MW, Gozal D, Gaston B. S-nitrosothiols signal the ventilatory response to hypoxia. Nature 2001 413 171-174. Fandrey J. Hypoxia-inducible gene expression. Respir Physiol 1995 101 1-10. Semenza GL. Hypoxia-inducible factor 1 and the molecular physiology of oxygen homeostasis. J Lab Clin Med 1998 131 207-214. 

Tanaka H, Cao YH, Berkenstam A, Poellinger L. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene 49. expression. Nature 2001 414 550-554. 

A catecholaminergic cell line, rat pheochromo-cytoma (PC 12) cells, that has been proven to be a useful system to study hypoxia-regulated gene expression, at 5% O2 rapidly induced a persistent phosphorylation of cyclic AMP response element binding protein (CREB) on Ser (Beitner-JOHNSON and Millhorn 1998), an element that is required for CREB-mediated transciptional activation (Gonzalez and Montminy 1989, Bonni et al. 1995). PC 12 cell cultures exhibited a loss of cells and increase in intracellular oxidative stress when exposed to ethanol for 24 h (Li et al. 2001). Catalase (EC 1.11.1.6) can attenuate this ethanol-induced cell loss and oxidative stress. 

Cooper C, Liu G-Y, Niu Y-L, Santos S, Murphy LC, Watson PH (2004) Intermittent hypoxia induces proteasome-de-pendent down-regulation of estrogen receptor a in human breast carcinoma. Clin Cancer Res 10 8720 8727 Dachs GU, Tozer GM (2000) Hypoxia modulated gene expression Angiogenesis, metastasis and therapeutic exploitation. Eur J Cancer 36 1649 1660 Di Paolo A, Bocci G (2007) Drug cUstribution in tumors mechanisms, role in drug resistance, and methods for modification. Curr Oncol Rep 9 109 114 Douple EB, Richmond RC (1978) Platinum complexes as radiosensitizers of hypoxic mammalian cells. Br J Cancer Suppl 3 98-102... 

Le Jan S, Le Meur N, Cazes A, Philippe J, Le Cunff M, Leger J, Corvol P, Germain S. 2006. Characterization of the expression of the hypoxia-induced genes neuritin, TXNIP and IGFBP3 in cancer. FEES Lett 580 3395-3400. 

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