Cylindrocarpon radicicola

Rhi pus nigricans Cylindrocarpon radicicola Curvularia lunata Curvularia lunata... 

On the other hand, Cylindrocarpon radicicola and Streptomyces lavendulae transform progesterone (22) into the antitumor substance testolactone (25) in 85% overall yield408. In this case, the reaction sequence is characterized by initial A -dehydrogenation. 

Other microbial strains capable of carrying out Baeyer-Villiger oxidations on steroids are Fusarium lint IFO 7156443, Fusarium solani413, Hwnicola sp.447, Paecilomyces sp.44S and Peni-cillium lilacinum NRRL 895416. The substrate specificity can be broadened by the use of a purified enzyme from Cylindrocarpon radicicola in this case several other steroids are oxidized422 423. 

Steroid monooxygenase Cylindrocarpon radicicola ATCC 11011 1 2 identical subunits NADPH 115 (56 each) 1 FAD per subunit 7.8 [83]... 

In 1953, after the resurgence of interest in the field. Fried, Thoma, and Klings-berg (F-284) and Vischer and Wettstein (V-1056) discovered the 1-dehydrogenation reaction. The former, usii Cylindrocarpon radicicola with progesterone, testosterone, and Compound S showed that in all instances 1-dehydrotestololactone was... 

Laskin and Diassi (L-492) have reported the only example of reduction of a steroidal bromide. Cylindrocarpon radicicola transformed 9a-bromo-ll-ketoprogester-one into 1-dehydro-11-ketotestololactone. Reductive removal of halide from an a-halo-ketone is well known in organic chemistry and can be done very efficiently with a variety of reducing systems. 

Ap-63 Rahim, M. A., and Sih, C. J., J. Biol. Chem. 241. 3615 (1966). In vitro studies of oxygenase and esterase from Cylindrocarpon radicicola. Degradation of progesterone, 17a-hydroxyprogesterone, 16-dehydroprogesterone, deoxycorticosterone, and 16a, 17a-oxidoprogesterone to C-19 steroids. 

In early studies of the potentialities of tritium labeling and % NMR for the solution of biochemical problems, the 1,2-dehydrogenation of testosterone by Cylindrocarpon radicicola was easily and unambiguously shown to proceed by a stereospecific la,23-trans-diaxial elimination (39,48). The substrate fed to the mould comprised 5 parts of [la,2a- H2ltestosterone (XVII) with 1 part of the [13product consisted... 

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