Antithymocyte Globulin Rabbit

Class Immunosuppressant gamma globulin, obtained by immunization of rabbits with human thymocytes [Pg.6]

Mechanism of Action Antibodies of multiple specificities interact with lymphocyte surface antigens, depleting numbers of circulating T-lymphocytes and modulating T-lymphocyte activation, homing and cytotoxic processes [Pg.6]

Indication Treatment of acute renal allograft rejection in combination with other immunosuppressants [Pg.6]

Contraindication History of anaphylaxis or allergy to Thymoglobulin or rabbit proteins, or acute viral illness [Pg.6]

Warnings Should be administered in facilities equipped and staffed with adequate laboratory and supportive medical resources Anaphylaxis has been reported Thrombocytopenia or neutropenia may result but are reversible with dose reduction or discontinuance [Pg.6]

Antithymocyte Globulin Rabbit 1.5 mg/kg IV x 3-14 days Flu-like symptoms, chills, rigors, 5,434- 25,358... [Pg.836]

Antibodies and derivatives Thymoglobulin, antithymocyte globulin (rabbit), purified rabbit IgG against human thymocytes Sangstat Lyophilized 25 mg vial, reconstitute to 5 ml IV ... [Pg.451]

Thymoglobulin. antithymocyte globulin (rabbit), purified rabbit IgG against human thymocytes... [Pg.524]

Antithymocyte globulin (equine) - ATGAM Antithymocyte globulin (rabbit) -Thymoglobulin Azathioprine... [Pg.1]

Antithymocyte globulin (rabbit) is approved for the reversal of acute rejection. A double-blind, randomized trial of thymoglobulin vs ATGAM was conducted in 163 renal recipients with rejection. Thymoglobulin had a higher reversal rate than ATGAM (88% vs 76%, p=0.027). Transplantation 66 29-37, July 15, 1998. [Pg.6]

Brennan DC, Daller JA, Lake KD, Cibrik D. 2006. Rabbit antithymocyte globulin versus basiliximab in renal transplantation. NEJM. 355 1967-1977. [Pg.122]

The antithymocyte globulin (ATG) Fresenius S, produced in rabbits, is an example of a polyclonal antibody mixture used in immunosuppressive therapy in combination with other immunosuppressive agents (e.g., cyclosporine, prednisone) after organ transplantation. [Pg.53]

Immunosuppression is used in patients who are not candidates for bone marrow transplantation due to age or to the lack of a donor (up to 70%). Horse antithymocyte globulin (ATG) or rabbit antilymphocyte globulin (ALG) induce haematological responses (transfusion-independence and freedom from infection) in 40-50%. The addition of ciclosporin to ATG or ALG improves response rates to 70-80% and survival rates in responders to 90%. Adverse effects of ATG and ALG include anaphylaxis, exacerbation of cytopenias and serum sickness. Ciclosporin is nephrotoxic. In refractory patients G-CSF and erythropoetin can improve blood counts, as can androgens in some patients. [Pg.600]

The adverse effects of rabbit antithymocyte globulin in transplant recipients were pain and erythema at the injection site and in one instance polyarthritis with urticaria (130). Four cases in which malignant lymphoma developed in renal transplant recipients treated with antithymocyte globulin of animal origin have been reported (131). [Pg.1725]

Anti-thymocyte globulin (ATG, thymoglobulin) is a polyclonal rabbit antithymocyte globulin that has been used as an immunosuppressive agent in kidney and hver transplant patients. Despite a fairly high safety profile, reported side effects of ATG include hypertension, leucopenia and ARDS [109]. Renal adverse effects are extremely rare only two case reports describe the occurrence of acute renal failure in patients treated with ATG [110, 111]. Cessation of ATG therapy in both cases and plasmapheresis in one case resulted in full recovery. [Pg.693]

Marvin MR, Drogan C, Sawinski D, et al. Adnunistration of rabbit antithymocyte globulin (Thymoglobulin) in ambulatory renal-transplant patients. Transplantation 2003 75 488 89. [Pg.1642]

ANTITHYMOCYTE GLOBULIN Antithymocyte globulin is a purified gamma globulin from the serum of rabbits immunized with human thymocytes. [Pg.917]

Indicated and approved for the management of allograft rejection in renal transplant patients, antithymocyte globulin preparations are purified immune globulins (primarily IgG) from horses or rabbits immunized with human thymus lymphocytes. The resultant globulin preparations contain cytotoxic antibodies to human T lymphocytes which function as an immunosuppressive agent. As well as its use for the treatment of renal transplant rejection, anti-thymocyte globulin may be administered as an adjunct to other immunosuppressive... [Pg.382]

Antithymocyte globulin (ATG) has been used to treat WG refractory to other agents. In one study, three of four patients with severe orbital WG responded to rabbit ATG (2 partial, 1 complete) (197). In an open-label study, 15 patients with active refractory WG were treated with ATG (198). The patients had received a mean of 5.2 different therapies without control of disease. Favorable responses to... [Pg.627]

France anti-thymocyte globulin antibody Thymo- globuline Thymoglobulin Polyclonal rabbit antithymocyte antibodies Immuno- suppressant... [Pg.460]

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