Antithymocyte globulins

Nonspecific immunosuppressive therapy in an adult patient is usually through cyclosporin (35), started intravenously at the time of transplantation, and given orally once feeding is tolerated. Typically, methylprednisone is started also at the time of transplantation, then reduced to a maintenance dose. A athioprine (31) may also be used in conjunction with the prednisone to achieve adequate immunosuppression. Whereas the objective of immunosuppression is to protect the transplant, general or excessive immunosuppression may lead to undesirable compHcations, eg, opportunistic infections and potential malignancies. These adverse effects could be avoided if selective immunosuppression could be achieved. Suspected rejection episodes are treated with intravenous corticosteroids. Steroid-resistant rejection may be treated with monoclonal antibodies (78,79) such as Muromonab-CD3, specific for the T3-receptor on human T-ceUs. Alternatively, antithymocyte globulin (ATG) may be used against both B- and T-ceUs. [Pg.42]

Both globulins exert their effect by depletion of circulating lymphocytes either by complement-dependent lysis or by phagocytosis after opsonization. However, antilymphocyte globulin (ALG) and antithymocyte globulin (ATG) are nonhuman polyclonal antibodies. To prevent sensitization application is restricted to a time period of several days only. [Pg.619]

Also known as antibody-mediated rejection, humoral rejection is the process of creating graft-specific antibodies.1,4 This type of rejection occurs less frequently than cell-mediated acute rejection. Humoral rej ection is characterized by deposition of immunoglobulins and complement in allograft tissues. Treatment for this type of rejection is not well defined, yet several reports have shown that treatments such as plasmapheresis, immunoglobulin therapy, rituximab, and/or antithymocyte globulin maybe effective. [Pg.834]

Antithymocyte Globulin Rabbit 1.5 mg/kg IV x 3-14 days Flu-like symptoms, chills, rigors, 5,434- 25,358... [Pg.836]

Adverse reactions are common and may include fever (63%), chills (57%), headache (40%), nausea (37%), diarrhea (37%), malaise (13%), dizziness (9%), leukopenia (57%), thrombocytopenia (37%), and generalized pain (46%).7,8,11 The incidence of infection is 37%, with CMV disease occurring in 13% of patients. There are no reported drug-drug interactions (DDIs) with the use of antithymocyte globulin at this time.7,8,11... [Pg.837]

The final chapter comprises two reports on clinical haematopoietic stem cell transplantation (HSCT). Viktor Khomenko shares the experience of the Kiev center for stem cell transplantation. The final article in this book by Axel Zander and colleagues summarises data with the use of Antithymocyte globuline (ATG) in (HLA-mismatched) allogeneic transplantation, an approach which was promoted in the Hamburg Clinic for HSCT. [Pg.285]

Therapy, when replacement of the marrow by allogeneic haematopoietic stem cell transplantation is not possible, comprises 500 mg of methylpred-nisolone by 8 hour intravenous infusion repeated for five consecutive days. Concurrently 15 mg/kg of antilymphocyte or antithymocyte globulin is given... [Pg.733]

Antithymocyte globulin (Atgam) is purified immune globulin obtained from hyperimmune serum of horses... [Pg.661]

Antithymocyte globulin binds to circulating T lymphocytes in the blood, which are subsequently removed from the circulation by the reticuloendothelial system. This globulin also reduces the number of T lymphocytes in the thymus-dependent areas of the spleen and lymph nodes. [Pg.661]

Antibodies and derivatives Thymoglobulin, antithymocyte globulin (rabbit), purified rabbit IgG against human thymocytes Sangstat Lyophilized 25 mg vial, reconstitute to 5 ml IV ... [Pg.451]

Thymoglobulin. antithymocyte globulin (rabbit), purified rabbit IgG against human thymocytes... [Pg.524]

ADA Adenosine deaminase ALG Antilymphocyte globulin APC Antigen-presenting cell ATG Antithymocyte globulin CD Cluster of differentiation CSF Colony-stimulating factor CTL Cytotoxic T lymphocyte DC Dendritic cell... [Pg.1179]

Antisera directed against lymphocytes have been prepared sporadically for over 100 years. With the advent of human organ transplantation as a therapeutic option, heterologous antilymphocyte globulin (ALG) took on new importance. ALG and antithymocyte globulin (ATG) are now in clinical use in many medical centers, especially in transplantation programs. The antiserum is usually obtained by immunization of large animals such as horses or sheep with human lymphoid cells. [Pg.1195]

Parenteral 100 mg/mL prefilled glass syringes for SC injection Antithymocyte globulin (Thymoglobulin)... [Pg.1205]

Antithymocyte globulin (equine) - ATGAM Antithymocyte globulin (rabbit) -Thymoglobulin Azathioprine... [Pg.1]

Antithymocyte globulin (rabbit) is approved for the reversal of acute rejection. A double-blind, randomized trial of thymoglobulin vs ATGAM was conducted in 163 renal recipients with rejection. Thymoglobulin had a higher reversal rate than ATGAM (88% vs 76%, p=0.027). Transplantation 66 29-37, July 15, 1998. [Pg.6]

Antithymocyte Globulin (See Lymphocyte Immune Globulin) [Immunosuppressive Agent]... [Pg.78]

See also in sourсe #XX -- [ Pg.465 ]

See also in sourсe #XX -- [ Pg.101 ]

See also in sourсe #XX -- [ Pg.598 ]

See also in sourсe #XX -- [ Pg.53 ]

See also in sourсe #XX -- [ Pg.693 ]

See also in sourсe #XX -- [ Pg.160 , Pg.178 ]

See also in sourсe #XX -- [ Pg.1578 ]

See also in sourсe #XX -- [ Pg.497 , Pg.500 ]

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