Antineoplastic agents drugs

Folic Acid Vitamin B12 Antineoplastic Agents Antiprotozoal Drugs... 

Arnold, L. J., Dagan, A., and Kaplan, N. O., Poly(L-lysine) as an antineoplastic agent and a tumor-specific drug carrier,... 

H. Sezaki, M. Hashida, and S. Muranishi, Gelatin microspheres as carriers for antineoplastic agents, in Optimization of Drug Delivery (H. Bundgaard, A. B. Hansen, and H. Kofod, eds.), Munksgaard, Copenhagen, 1982, p. 316. 

DNLM 1. Antineoplastic Agents, Combined—administration dos age—Handbooks. 2. Antineoplastic Agents, Combined—therapeutic use —Handbooks. 3. Neoplasms—drug therapy—Handbooks. QV 39 L276c 2001]... 

Considering all aspects, sex hormones, antibacterials, and antineoplastic agents were identified by Christensen as the three most relevant groups of chemicals concerning their potential human risk as a consequence of drug exposure via the environment [10]. Immunochemical methods for hormones and antibiotics have already been discussed above. In this section we will describe methods based on the use of antibodies for the analysis of analgesics, NSAIDs, and cytostatic agents. 

Finally these compounds may also present in the future some interest in the area of novel anti-tumor drugs, or in photochemotherapy [12], Up to now the mechanism of action of the Pt complexes as antineoplastic agents has been extensively examined [13]. In spite of their successful applications, there is a need in compounds that are less toxic than the Pt derivatives. Therefore novel photo-active metallic compounds could offer future possibilities for cancer treatment. The fact that a drug would become active exclusively under illumination might represent an advantage. 

Pettit GR, Temple C, Narayanan VL, Varma R, Simpson MJ, Boyd MR, Rener GA, Bansal N. (1995) Antineoplastic agents 322. Synthesis of combretastatin A-4 prodrugs. Anticancer Drug Des 10 299-309. 

Pettit GR, Lippert JW. (2000) Antineoplastic agents 429. Syntheses of the combretastatin A-1 and combretastatin B-1 prodrugs. Anti-Cancer Drug Des 15 203-216. 

To function, Ras must be attached to the plasma membrane. Translocation from the cytoplasm to membrane requires a series of posttranslational modifications that begin with farnesylation of the cysteine residue, the fourth amino acid residue from the C terminus of the protein, by famesyl protein transferase (FPTase) (64). Attachment of the hydrophobic 15-carbon lipid farnesyl group allows Ras molecule insertion into the plasma membrane and is crucial for Ras signaling activity and transformation properties. As farnesylation is required for oncogenic Ras function, FPTase inhibitors (FTIs) are obvious candidate antineoplastic agents. Several drugs that inhibit Ras farnesylation are at various stages of clinical development (65). 

Intensive intermittent schedules of drug treatment should allow time for recovery from the acute toxic effects of antineoplastic agents, primarily bone marrow toxicity. The use of non-myelosuppressive agents can be considered during the recovery period, especially for treatment of fast-growing cancers. 

To optimize drug therapy, it is necessary to know in what phase of the cell cycle antineoplastic agents are effective. Which one of the following agents is cytotoxic only to cells in the S-phase of the cycle ... 

E. Intensive intermittent schedules allow time for recovery from the acute toxic effects of the antineoplastic agents. If a drug has no activity by itself, it is not likely to be beneficial in a combination. It is important not to include two drugs with the same dose-limiting toxicity. Most curable tumors require at least six to eight cycles of therapy. 

Figure 7.1 Drug targets at the level of cellular structure. The mammalian cell presents a variety of druggable targets. The most important ones are located at the level of the cell membrane. Within the cell, cytoplasmic organelles, such as mitochondria, are beginning to be exploited as potential drug targets. The nucleus, at the center of the cell, is an important target for the development of antineoplastic agents for the treatment of cancer.

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