Antiinfective drugs

Kidd SE, Nelson MJ, Epstein M, Aszalos A, Pine S, Molnar J (1997) Antiinfect Drugs Chemother 15 71-77... 

By 1996, with New York City squeezing its public hospitals budgets for several years in a row, his work at Kings County wasn t so enjoyable any more. He still might not have listened to just any headhunter. But this time, the job offer was at Merck, as the liaison between the researchers working on two antiinfective drugs and the FDA. The fact that it was... 

Iavarone, L., Scandola, M., Pugnaghi, F. and Grossi, P. Qualitative analysis of potential metabolites and degradation products of a new antiinfective drug in rat urine, using HPLC with radiochemical detection and FIPLC-mass spectrometry. ]. Pharm. Biomed. Anal. 13 607-614, 1995. 

A. Schwarz and A. Perez-Canto, Nephrotoxicity of antiinfective drugs. Int J Clin Pharmacol r/zer 36 164-167 (1998). 

J. M. Nicolas, P. Pirson, and B. Leclef. Acetylated LDL as a vehicle for antiinfections drugs preparation and antileishmanial activity of acetylated-LDL containing ketoconazole-oleate. Ann. Top. Med. Parasitol. 8i(40) 325-336 (1990). 

Del Vecchio AM, Sarisky RT (2006) Cold virus fusion or stopping fusion cold - inhibitors of the human respiratory syncytial virus F protein. Recent Pat Antiinfect Drug Discov 1 247-254... 

D Mlangeni, F Daschner. Povidone-iodine. Evaluation of povidone-iodine as an antiseptic. Antiinfect Drugs Chemother 13 161-167, 1995. 

Gilbert J, Senyuva HZ (2008) Bioactive compounds in foods. Blackwell Publishing, Oxford Goncagul G, Ayaz E (2010) Antimicrobial effect of garlic (Allium sativum). Recent Pat Antiinfect Drug Discov 5 1-3... 

Very few injectable dosage forms have been specifically developed and approved by FDA for intraocular use. However, the ophthalmologist uses available parenteral dosage forms to deliver antiinfectives, corti-costerioids, and anesthetic products to achieve higher therapeutic concentrations intraocularly than can ordinarily be achieved by topical or systemic administration. These unapproved or off-label uses have developed over time as part of the physician s practice of medicine. However, these drugs are usually administered by subconjunctival or retrobulbar injection and rarely are they injected directly in the eye [301]. 

Antiarrhythmic drugs Antihistamines Antiinfectives Psychiatric drugs Others... 

Natural products offer a source of unique chemical diversity for the pharmaceutical industry. Numerous successful drugs derived from natural products have been introduced for the treatment of cancer (Hung et al., 1996 Pettit et al, 1994), immunosuppression (Perico et al., 1996), cardiovascular therapy (Nadin and Nicolaou, 1996 Tomoda et al., 1994), and antiinfective therapy (Turner and Rodriguez, 1996). 

Antiinfective, cephalosporin antibiotic Antibacterial for bronchitis, cephalosporin antibiotic Antibiotic URTI, LRTI, UTI Cephalosporin Antibiotic Antibiotic Antibiotic NSAID Anti-HIV Oral contraceptive Antidepressant Veterinary drug Lipid-lowering Agent Seasonal rhinitis perennial allergic rhinitis pruritus... 

Respiratory distress syndrome Veterinary drug Antiinfective... 

Analgesics Anticholinesterases Antiemetics Antiinfectives Antimigraine drugs Antimuscarinics Cardiovascular drags CNS stimulants... 

In 1986 he became Head of the central toxicology department at Hoechst AG. This entailed responsibility for the entire Hoechst portfolio, and hence also for pharmaceuticals. He was involved in the successful development of antiinfectives, cardiovascular drugs, several insulins, CNS drugs and anti-rheumatics. In 1998 he was promoted to Vice President of Lead Optimization (Toxicology, DMPK and Clin. Pharmacology). 

United States Food and Drug Administration. Transcript of Antiinfective Advisory Subcommittee Meeting on May 1, 1989. U.S. Government Printing Office, Washington, DC. 

FIGURE 2.2 An example of fine-tuning of pharmacologically active chemicals Erythromycin 2 -ethylsuccinate and clarithromycin are semisynthetic derivatives of the macroUde antiinfective erythromycin. The small molecular change in the former leads to the elimination of bitterness which is important as this class of drugs is often used in pediatrics and administered as a syrup. In the latter, because hemiketal formation is no longer possible (arrow), clarithromycin is stable in the acidic milieu of the stomach (pH 2). 

---