Antiinfectives

Perez-Pineiro et al. [92] reported the implementation of a sequential computational approach for virtual screening to identify inhibitors of trypanothione reductase (TryR). Their workflow combines a 2D similarity-based virtual screening using a fragment-based Bayesian model with docking into the X-ray structure of TryR from Trypanosoma cruzi employing Autodock [93]. The 2D model significantly reduced 

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Additional discussions are available in the General References concerning the properties of several nitrofiirans. This includes further coverage of the chemotherapeutic and physical properties antimicrobial activity bacterial resistance absorption, distribution, and excretion clinical use and safety studies, of this interesting class of antiinfective compounds. 

Also includes antiproto2oan agents and other urinary tract antiinfectives, but does not include the antileprotic sulfones. 

L-Dopa and Trimethoprim are two other dmgs that can be made from vanillin. u-Dopa is used for the treatment of Parkinson s disease Trimethoprim is an antiinfective agent used mainly for urinary tract infections and certain venereal diseases. Also, Mebeverine, an antispasmodic agent, and Verazide, a generic antitubercular agent, are dmgs that can be made from vanillin or its derivatives. 

As demonstrated above, nitro derivatives of five-membered heterocycles have found extensive use as antiinfective agents. It is therefore of interest that the nitro derivative of a substituted thiazole was at one time used as an antitrichomonal agent. Bro-mination of 2-aminothiazole (136) (obtained from condensation of thiourea with chloroacetaldehyde) gives the 4-bromo derivative (138) this is then acetylated to 139. Treatment of 139 with nitric acid leads to an interesting displacement of bromine by a nitro group to afford aminitrazole (140)... 

The finding that 2,4-diaminopyrimidines inhibit the growth of microorganisms by interfering with their utilization of folic acid led to an intensive search for antiinfective agents in this class of heterocyclic compounds. This work led to the develop-... 

Therapeutic Function Mucolytic expectorant nasal antiinfective Chemical Name S-(carboxymethyl)-L-cysteine Common Name —... 

Bentley P.H. Ponsford R. (199 3) Recent Advances in the Chemistry of Antiinfective Agents. London Royal Society of Chemistry. 

Very few injectable dosage forms have been specifically developed and approved by FDA for intraocular use. However, the ophthalmologist uses available parenteral dosage forms to deliver antiinfectives, corti-costerioids, and anesthetic products to achieve higher therapeutic concentrations intraocularly than can ordinarily be achieved by topical or systemic administration. These unapproved or off-label uses have developed over time as part of the physician s practice of medicine. However, these drugs are usually administered by subconjunctival or retrobulbar injection and rarely are they injected directly in the eye [301]. 

Antiinfective therapy for Candida should be withheld until the infecting species is identified. 

Dalla Gosta, T., Nolting, A., Rand, K., and Derendorf, H., Pharmacokinetic-pharmacodynamic modeling of the in vitro antiinfective effect of piperacillin-tazobactam combinations, Int.. Clin. Pharmacol. Ther., 35, 426-433,1997. 

Antiarrhythmic drugs Antihistamines Antiinfectives Psychiatric drugs Others... 

Khalifa AE. Antiinfective agents affecting cognition a review. J Chemother 2007 19(6) 620-31. 

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