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Antihistamines cetirizine

Grandi, T., Carrupt, P.A., Fruttero, R. and Testa, B. (2001) Molecular dynamics and NMR e5q)loration of ihe properly space of ihe zwitterionic antihistamine cetirizine. Helvetica Chimica Acta, 84, 360-374. [Pg.116]

Severe urticaria and anaphylaxis associated with pyridostigmine (an unspecified dose) occurred in a 54-year-old woman with myasthenia gravis (9). Urticaria started almost immediately after introduction of the drug but was partially controlled by the antihistamine cetirizine. However, pyridostigmine was stopped after 2 months and the urticaria resolved completely. Rechallenge with oral pyridostigmine led to an anaphylactic reaction that was treated with subcutaneous adrenaline. There were no sequelae. [Pg.13]

Azelastine has been compared with the potent antihistamine cetirizine in the treatment of pruritic dermatoses. Taste disturbance occurred in 9.7% of patients taking azelastine and headaches in 10.4% of patients taking cetirizine (3). [Pg.388]

Nicholson AN, Turner C. Central effects of the Hl-antihistamine, cetirizine. Ayiat Space Enyiron Med... [Pg.703]

Kranke B, Kern T. Multilocalized fixed drug eruption to the antihistamine cetirizine. J Allergy Clin Immunol 2000 106(5) 988. [Pg.704]

Examples of applications of this analysis include the dissociations ol aminobenzoic acids [437], arginine [438], the anti-inflammatory drug niflumic acid [439], and the antihistamine cetirizine [440]. [Pg.105]

Antihistamines are drags used to counteract the effects of histamine on body organs and structures. Examples of antihistamines include diphenhydramine (Benadryl), loratadine (Claritin), fexofenadine (Allegra), and cetirizine (Zyrtec). A new antihistamine, deslorata-dine (Clarinex), is die active metabolite of loratadine and is intended to eventually replace loratadine (Claritin). Topical corticosteroid nasal sprays such as fluticasone propionate (Flonase) or triamcinolone ace-tonide (Nasacort AQ) are also used for nasal allergy symptoms. See Chapter 56 for more information on die topical corticosteroids. [Pg.325]

The belief that histamine (HT) has a central effect stems from the knowledge that all the classical antihistamines (Hi receptor antagonists) used to treat allergic reaction, such as hay fever, caused marked sedation if, like mepyramine and promethazine, they can cross the blood-brain barrier, but fail to do so if, like terfenedine and cetirizine, they do not. [Pg.269]

Values are the means from six separate experiments. SE was less than 10% of the mean. Dose of test compounds, chlorpheniramine maleate and cetirizine are 10 mg/kg for antihistaminic activity, and 5 mg/kg for sedative-hypnotic activity... [Pg.126]

As sedation is one of the major side effects associated with antihistamines, the test compounds were also evaluated for their sedative potentials. This was determined by measuring the reduction in locomotor activity using an ac-tophotometer [6,7]. The test compounds and the reference standards (chlorpheniramine maleate and cetirizine) were administrated orally at a dose of 5 mg/kg in 1% CMC. [Pg.127]

First-generation antihistamines are effective, but associated sedation and psychomotor impairment limit chronic use. Efficacy and safety of second-generation antihistamines in children have been demonstrated in clinical trials.33 Cetirizine is indicated for children 6 months of age and older, loratadine for children 2 years of age and older, and fexofenadine for children 6 years of age and older.15... [Pg.933]

Intranasal corticosteroids are the most effective treatment for allergic rhinitis during pregnancy. Beclomethasone and budesonide have been used most. Nasal cromolyn and first-generation antihistamines (chlorpheniramine, tripelennamine, and hydroxyzine) are also considered first-line therapy. Loratadine and cetirizine have not been as extensively studied. [Pg.371]

For example, a pharmacist was asked to prepare 30-0 ml of a solution of cetirizine hydrochloride (an antihistamine medicine) with a concentration of 5-0 mg/ml. The stock solution of cetirizine hydrochloride was 75-0 mg/ml. Calculate the volume of stock solution needed to prepare the diluted medicine. [Pg.88]

Cetirizine is a non-sedating antihistamine drug that may be used for symptomatic relief in allergic rhinitis (hay fever) as it reduces rhinorrhoea and sneezing. Fexofenadine is an active metabolite of terfenadine (another antihistamine). [Pg.212]

Second-generation antihistamines Flypersensitivity to specific or structurally related antihistamines. Desloratadine is contraindicated in those who are hypersensitive to loratadine. Cetirizine is contraindicated in those who are hypersensitive to hydroxyzine. [Pg.802]

Although the antihistamines are not useful as primary agents in the treatment of asthma, a number of studies have shown that the second-generation compounds are effective as adjunctive therapies in asthmatic patients with concomitant rhinitis, urticaria, or dermatitis. Cetirizine has been used to prevent the progression from atopic dermatitis to asthma in young children. [Pg.455]

Cetirizine is a potent antihistaminic with a low potential for drowsiness at pharmaco-... [Pg.218]

The second generation H -receptor antagonist cetirizine is a reacemate consisting of equal quantities of 2 enantiomers, levocetirizine [(R)-enantiomer] and dextrocetirizine [(S)-enantiomer]. In vitro and human pharmacodynamic studies have provided evidence that levocetirizine is the more active enantiomer, accounting for most or all clinical antihistaminic activity of racemic cetirizine this activity of levocetirizine is seen at half the dose of cetirizine. [Pg.218]

For the synthesis of cetirizine hydrochloride 45, diarylmethylamine 47b was of particular importance, since deprotection under acidic conditions led to 49, which is a known intermediate for the synthesis of the desired antihistamine agent. As... [Pg.190]

Enantiomerically pure diarylmethylamines are important intermediates in the synthesis of biologically active compounds such as 28 or 29 (Fig. 2.1.3.8). Among several drug candidates, Cetirizine hydrochloride (28) stands out as a commercially important nonsedative antihistamine agent. Binding studies indicate that... [Pg.209]

Cetirizine (Zyrtec, Zyrtec D) [Allergy/Antihistamine] Uses ... [Pg.107]


See other pages where Antihistamines cetirizine is mentioned: [Pg.265]    [Pg.95]    [Pg.72]    [Pg.77]    [Pg.68]    [Pg.368]    [Pg.1515]    [Pg.253]    [Pg.81]    [Pg.265]    [Pg.95]    [Pg.72]    [Pg.77]    [Pg.68]    [Pg.368]    [Pg.1515]    [Pg.253]    [Pg.81]    [Pg.139]    [Pg.142]    [Pg.590]    [Pg.300]    [Pg.731]    [Pg.928]    [Pg.933]    [Pg.80]    [Pg.376]    [Pg.73]    [Pg.73]    [Pg.456]    [Pg.107]    [Pg.494]    [Pg.189]    [Pg.675]    [Pg.1340]    [Pg.1342]    [Pg.107]    [Pg.777]    [Pg.371]   
See also in sourсe #XX -- [ Pg.234 ]




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