Cetirizine hydrochloride

For example, a pharmacist was asked to prepare 30-0 ml of a solution of cetirizine hydrochloride (an antihistamine medicine) with a concentration of 5-0 mg/ml. The stock solution of cetirizine hydrochloride was 75-0 mg/ml. Calculate the volume of stock solution needed to prepare the diluted medicine. 

Children 6 to 12 years of age 1 to 2 teaspoonsful every 12 hours. Children 2 to 6 years of age % to 1 teaspoonful every 12 hours. CETIRIZINE HYDROCHLORIDE May be given with or without food. 

Piperazine derivatives cetirizine hydrochloride cyclizine lactate hydroxyzine hydrochloride meclizine hydrochloride... 

For the synthesis of cetirizine hydrochloride 45, diarylmethylamine 47b was of particular importance, since deprotection under acidic conditions led to 49, which is a known intermediate for the synthesis of the desired antihistamine agent. As... 

Enantiomerically pure diarylmethylamines are important intermediates in the synthesis of biologically active compounds such as 28 or 29 (Fig. 2.1.3.8). Among several drug candidates, Cetirizine hydrochloride (28) stands out as a commercially important nonsedative antihistamine agent. Binding studies indicate that... 

Fig. 2.1.3.8 Cetirizine hydrochloride 28, a potent 8-opioid receptor agonist, and (+)-Voronzole 29, an aromatase inhibitor.

The CBS reduction has been employed in numerous synthetic applications.16 The cetirizine hydrochloride 32 (Zyrtec) is an effective treatment as a second-generation histamine HI antagonist for a range of allergic diseases. Zyrtec is one of the leading antihistamine drugs, with sales of 1.3 billion in 2004 in the United States alone. Corey and Helal prepared a chiral benzylic alcohol intermediate 34 en route to their enantioselective synthesis of Zyrtec17 (Scheme 4.3m). The asymmetric reduction of the ketone 33 in toluene with catecholborane in... 

Oral antihistamines may be used to alleviate symptoms of allergic rhinoconjunctivitis. These include over-the-counter first-generation antihistamines such as chlorpheniramine maleate (Chlor-Trimeton) and diphenhydramine hydrochloride (Benadryl). Second-generation less sedating antihistamines include fexofenadine hydrochloride (Allegra), loratadine (Claritin), deslorata-dine (Clarinex), and cetirizine hydrochloride (Zyrtec). Dry eye symptoms may be an adverse reaction to oral antihistamines, including second generation. 

Corey EJ, Helal CJ (1996) Catalytic enantioselective synthesis of the second generation histamine agonist cetirizine hydrochloride. Tetrahedron Lett 37 4837-4840... 

---