Antihepatotoxic effect

Kapil A, Koul IB, Banerjee SK, Gupta BD. (1993) Antihepatotoxic effects of major diterpenoid constituents of Andrographis paniculata. Biochem Pharmacol 46 182-185. 

In order to prove the hypothesis obtained from HPLC profile analysis, antihepatotoxic effects of OGs obtained from Abri Herba were tested [30]. The tested OGs were representative ones, soyasaponin I (soyaspogenol B OG, 1) and kaikasaponin III (sophoradiol OG, 21). The antihepatotoxic activity was studied on liver injury induced by CC14 in primary cultured rat hepatocytes [31], Fig. (5). 

A. Ramanathan, R. Kittusamy, Antihepatotoxic effect of isolated chitin from Rhizopus ory-zae against paracetamol-induced hepatotoxicity, Bangladesh J. Pharmacol, 6,64-67,2011. 

These antihepatotoxic effects are due mainly to the lignans present in the seed, especially wuweizisu C,... 

Soyasaponin I (1) inhibited the elevation of aspartate aminotransferase (AST) activity, which was comparable to that of glycyrrhizin (positive control). On the other hand, Kaikasaponin HI (21) was more effective than 1. Compound 21 showed antihepatotoxic activity at less than 100p.g/ml. Furthermore, the highest activity was observed even at lower doses (50, 100pg/ml). Therefore, sophoradiol OGs were concluded to be the anti-hepatotoxic principle in both crude drugs (Abri Heba and Puerariae Flos). 

Agarwal, R. et al.. Inhibitory effect of silymarin an antihepatotoxic flavonoids on TPA-induced epidermal ornithine decarboxylase activity and mRNA in SENCAR mice. Carcinogenesis, 15, 1099, 1994. 

Garcinia kola Heckel (seeds) 3",4, 4", 5,5",7,7"-Heptahydroxy-3,8-biflavanone (GBi) (176) GB2 (177) Kolaviron (KV) [a mixture of (C-3,C-8)-linked biflavonoids GBi (177) + GB2 (177) + kolaflavanone (178)]. Traditional medicine in the West and Central African sub-region. Poison antidote. Seeds have been used in traditional African medicine to treat diabetes. Antioxidant and antihepatotoxic properties. KV showed antioxidant, hepatoprotective and hypoglycaemic effects. KV inhibited rat lens aldose reductase (RLAR) activity, had antidiabetic and hypolipidaemic effects, and showed immunomodulatory and immunorestorative properties. Maurice, 1982[186] Iwu et al., 1987[187], 1990[101] Farombi et al., 2000[188] Adefule-Ositelu et al., 2004[189] Adaramo ye and Adeyemi, 2006[190, 191] Nworu et al., 2008[192] Okoko, 2009[113]. 

Biosynthesis of the flavonolignan silymarin, a constitutive compound from the fruit of Silybum marianum with strong antihepatotoxic and hepatoprotective activities, is severely reduced in cell cultures of this species. It is well known that elicitation is one of the strategies employed to increase accumulation of secondary metabolites. YEs, chitin, and chitosan were compared with respect to their effects on silyamarin accumulation in S. marianum suspensions with YE-stimulated production (Sanchez-Sampedro et al. 2005). 

The unusual flavonoid derivative kuwanon G, 30, is reported to lower blood pressure in rabbits when administered intravenously at a dose of l.Omg/kg of body weight (743). (-h)-Catechin [(-h)-cyanidan-3)ff-ol], 31, is remarkably bioactive. Among its recently reported biological effects are the following antianaphylactic (517), anticoagulant (569), antihepatotoxic (963), platelet aggregation inhibition (118), and serotonin secretion inhibition (100) effects. 

Kiso Y, Tohkin M, Hikino H, Hattori M et al. 1984 Mechanism of antihepatotoxic activity of glycyrrhizin, I Effect on free radical generation and lipid peroxidation. Planta Med 51 298-302... 

Hesperetin has a variety of biological effects in numerous mammalian cell systems, in vitro as well as in vivo. They have been shown to exert antimicrobial, antiviral, antiulcerogenic, cytotoxic, antineoplastic, mutagenic, anti-inflammatory, antioxidant, antihepatotoxic, antihipertensive, hypolipidemic and antiplatelet activities. The next topic will discuss the biological potential of hesperetin eombating tropical diseases, anti-tumor, obesity, diabetes and cardiovascular diseases. 

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