Antigenic substances

Antigen Substance that can incite the production of a specific antibody and that can combine with that antibody. 

Sustained-release injections, subcutaneous and intramuscular, have been investigated in a variety of different formulations [217,218], Injections of degradable microspheres have efficiently prolonged delivery of numerous drugs [219-222], even antigenic substances and vaccines to produce immunity [223,224]. 

As a bacterial protein, streptokinase is viewed by the human immune system as an antigenic substance. In some cases, its administration has elicited allergic responses that have ranged from mild rashes to more serious anaphylactic shock (an extreme and generalized allergic response characterized by swelling, constriction of the bronchioles, circulatory collapse and heart failure). 

Side effects associated with diethylcarbamazine include headache, malaise, weakness, and loss of appetite. More severe reactions (fever, acute inflammatory response) may also occur following diethylcarbamazine use, but these reactions may be caused by the release of antigenic substances from the dying roundworms rather than from the drug itself. 

Allergen An antigenic substance capable of eliciting an allergic response. 

Atopic Pertaining to genetic predisposition toward developing immediate hypersensitivity reactions to antigenic substances. 

As revealed by gel electrophoresis and agar diffusion, two new antigenic substances were obtained as the major components of extracts of human colon tumors with the KC1-HC1 solution. The coupled electrophoresis-agar diffusion analysis showed that the components reacted with immune serum from rabbits immunized with new antigens. These antigens are present in colon tumor tissue but were not present in normal colon tissue. The... 

Enzyme immunoassays are now firmly established as precise quantitative methods for the determination of various antigenic substances and antibodies. Proceedings of symposia, " reviews, " and monographs ... 

Up to this point we have been concerned primarily with so-called complete antigens, substances which both stimulate antibody production and react with the antibody so formed. Other substances, however, have a more limited antigenicity—e.g., while they react specifically with antibody, they are unable to stimulate antibody formation. These substances are partial antigens or haptens. The use of immunological and serological... 

Cross-reactivity. The ability of an antibody or a T cell specific for one antigen to react with a second antigen a measure of relatedness between two antigenic substances and/or polyspecificity of the antibody molecule (e.g. some rheumatoid factors) or of the T cell receptor. 

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