Antidepressant-like activity

Barr AM, Kinney JW, Hill MN et al (2006) A novel, systemically active, selective galanin receptor type-3 ligand exhibits antidepressant-like activity in preclinical tests. Neurosci Lett 405 111-115... 

Wieland S, Lucki I. (1990). Antidepressant-like activity of 5-HTlA agonists measured with the forced swim test. Psychopharmacology (Berlin). 101 4497-504. 

Tomonaga, S., Yamane, H., Onitsuka, E., Yamada, S., Sato, M., Takahata, Y., Morimatsu, F., and Furuse, M. (2008). Camosine-induced antidepressant-like activity in rats. Pharmacol. Biochem. Behav. 89,627-632. 

In humans, the antidepressant activity of NMDA receptor antagonists has not been evaluated extensively (Skohiick 1999). In animal models of depression, NMDA receptor antagonists have been reported to exert positive effects in most studies (Trullas 1997). This concerns mainly the forced swim test (Maj 1992 Moryl et al. 1993 PrzegaUnski et al. 1997) and stress-induced anhe-donia (Papp and Moryl 1994). Amantadine but not memantine was effective against reserpine-induced hypothermia (Moryl et al. 1993). In the forced swim test, both amino-adamantanes produced specific antidepressive-like activity (Moryl et al. 1993). 

Chaki S, Yoshikawa R, Hirota S, et al (2004) MGS0039 a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity. Neuropharmacology 46 457-467... 

Redrobe JP, Dumont Y, Fournier A, Quirion R (2002a) The neuropeptide Y (NPY) Y1 receptor subtype mediates NPY-induced antidepressant-like activity in the mouse forced swimming test. Neiuopsychopharmacology 26 615-624 Redrobe JP, Dmnont Y, Quirion R (2002b) Neiuopeptide Y (NPY) and depression From animal studies to the hmnan condition. Life Sci 71 2921-2937 Redrobe JP, Dmnont Y, Herzog H, Quirion R (2003) Neiuopeptide Y (NPY) Y2 receptors mediate behaviour in two animal models of anxiety evidence from Y 2 receptor knockout mice. Behav Brain Res 141 251-255... 

Kaidanovich-Beilin, O., Milman, A., Weizman, A., Pick, C.G., and Eldar-Finkelman, H., 2004, Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus. Biol. Psychiatry 55 781-784. 

Chenu F, Guiard BP, Bourin M, Gardier AM. Antidepressant-like activity of selective serotonin reuptake inhibitors combined with 87. a NKl receptor antagonist in the mouse forced swimming test. 

Lutrepulse gonadotrophin-releasing hormone, lutropin luteinizing hormone, luzindole (N-acetyl-2-benzyltryptamlne N 0774) is a melatonin receptor antagonist (with moderate selectivity for MeljB over the Meli subtype). It shows ANTIDEPressant-like activity in animal model. 

Table 3.6 Transformation (%) from prodrug 15 to active substance 14a and 14i by liver S9 fractions from rats, monkeys and humans, pharmacokinetics parameters for active substances, 14a and 14i, after oral dosing (lOmg/kg) of 14a, 14i, and prodrug 15 to rats and monkeys, and antidepressant-like activity of 14a and its prodrug 15a (MCS0210)... 

Antidepressant-like activity of jatamansi was observed in rats orally administered 100,200, or 400 mg/kg of an ethanol extract daily for 14 days. The antidepressant activity was attributed to a reduction in whole brain MAO-A and MAO-B activities and an increase in the level of monoamines. Pretreatment of animals with a GABA-B agonist resulted in a partial inhibition of the antidepressant effect, indicating a potential effect on GABA-B receptors (Dhingra and Goyal 2008). 

Dhingra, D., and P.K. Goyal. 2008. Inhibition of MAO and GABA Probable mechanisms for antidepressant-like activity of Nardostachys jatamansi DC. in mice. Indian. Exp. Biol. 46(4) 212-218. 

Lee, S.A., S.S. Hong, X.H. Han, et al. 2005. Piperine from the fruits of Piper longum with inhibitory effect on monoamine oxidase and antidepressant-like activity. Chem. Pharm. Bull. 53(7) 832-835. 

Rats (a) Piperine-administered animals possessed antidepression-like activity and cognitive-enhancing effect [82]... 

In vivo antidepressant-like activity of lO-hydroxy-2-decenoic acid (10-HDA) in stress-inducible depression-like mouse model was conducted. The animals were evaluated by the tail-suspension test, elevated plus-maze test, and open-field test at 1 day after the end of stress exposure. The results demonstrated that 10-HDA and RJ were effective in ameliorating the stress-inducible symptoms of depression and anxiety, intraperitoneally administered, while RJ given by the oral route was less effective [80]. 

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