Piper longum

Neuromuscular blocking activity. Decoction of the seed oil, administered orally to adults of both sexes at a dose of 4.6 g/per-son, was active. A mixture of Piper longum, Zingiber officinale, Piper cubeba, Curcuma zedoaria, Juniperus communis, Cichorium intybus, Mentha arvensis. Commiphora mukul, and Sesamum indicum was given. Twenty five patients with laquwa (spastic facial paralysis) were treated with this mixture in divided doses of 4.6 g in 24 hours. Six grams of a decoction of Lavendula stoechas was also given in some cases. Sev-... 

Piper longum L. Bi Ba (Indian long pepper) (fruit) Volatile oil, piperine, Antipyretic, carminative, aromatic stomachic, analgesic in gastralgia, flatulence, headache. 

Thalictrum dasycarpum, T occidentale Perilla frutescens Piper longum, P. nigrum Zingiber officinale Caulophyllum thalietroides Pulsatilla vulgaris... 

Shankaracharya, N.B., Rao, L.J., Naik, J.P. and Nagalakshmi, S. (1997) Characterisation of chemical constituents of Indian Long Pepper (Piper longum L.). journal of Food Science and Technology, Mysore 34(1), 73-75. 

Piper longum 1. Hypoxis hemerocallidea 1. Nevirapine t blood levels, with potential risk of side-effects Inhibits metabolizing CYP450 isoenzyme (nevirapine) Inhibits both CYP3A4 and P-gp (Hypoxis hemerocallidea) If either drug is introduced, monitor closely for side-effects... 

Piper nigrum and Piper longum 1. Amoxicillin 2. Cefotaxime 3. Rifampicin 4. Erythromycin 5. Telithromycin t blood levels of these antibiotics Attributed to inhibition of metabolism and of P-gp, e.g. Piper longum Be aware that toxic effects of antibiotics may occur, particularly when the prescriber/dispenser is unaware of the intake of herbal medicines... 

Herbal effects on absorption can affect the bioavailability of antibiotics and has been demonstrated for Khat (Catha endulis) users (Attef et al., 1997). Absorption and decreased metabolism of the asthma drug theophylline are also affected by piperine from black pepper (Piper nigrum, Piper longum). 

Dahanukar SA, Karandikar SM, Desai M. Efficacy of Piper longum in childhood asthma. Indian Drugs 1984 21 384-388. 

Upadhyaya SD, Kansal CM, Pandey NN. Clinical evaluation of Piper longum on patients of bronchial asthma—a preliminary study. Nagarjuna 1982 25 256- 258. 

Chatterjee, A. and Dutta, C.P. (1967) Alkaloids of Piper longum Linn - I. Structure and synthesis of piperlongumine and piperlonguminine. Tetrahedron, 23, 1769—1781. 

Dehydropipernonaline (132) was isolated from Piper longum and its structure was determined using HRMS, EIMS, UV, and H and 13c NMR [406]. This study also described its coronary vasodilating effect, as displayed by a concentration dependent inhibition of KCI-induced contraction of the coronary artery [406], In a recent synthesis, both 132 and pipernonaline (131) were prepared using a palladium catalyzed coupling of a ( )-p-bromoacrylamide with an alkynyl- or alkenyl-boronate, respectively [398],... 

The biosynthesis of 133 in Piper longum has been investigated [411], Feeding studies with L-[U-14c]-lysine and L-[U- l C]-phenylalanine demonstrated that the piperidine ring was derived from lysine and the phenylpropanoate moiety from phenylalanine (Scheme 3). DL-[2-l CJ-tyrosine and [2-14C]-sodium acetate were not significantly incorporated into 133 [411]. 

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