Cytotoxicity antibody-dependent

Perifascicular capillaries are closer to aggregates of antibody-secreting cells (B-lymphocytes) situated in perimysial connective tissue and therefore are most severely affected by antibody-dependent cytotoxic reactions. Immune-complex deposition occurs at a higher level in the vascular tree (i.e., at arteriolar level) and this may cause fluctuations in perfusion pressure. Perifascicular capillaries are most distal from the head of vascular pressure and therefore most likely to suffer from periodic anoxia. 

In mature neutrophils, interferon-7induces the expression of FC7RI, increases antibody-dependent cytotoxicity, primes the ability to generate reactive oxidants and selectively stimulates protein biosynthesis. These effects are described in detail in Chapter 7. Additionally, this cytokine has been used clinically for the treatment of chronic granulomatous disease (CGD), which is associated with an increased susceptibility to infections due to an impairment of NADPH oxidase function ( 8.2). 

ADCC—antibody-dependent cytotoxicity AEDS—atopic eczema/dermatitis syndrome AFM—atomic force microscopy... 

Type II reactions antibody-dependent cytotoxic type. The drug or metabolite combines with a protein in the body so that the body no longer recognises the protein as self, treats it as a foreign protein and forms antibodies (IgG, IgM) that combine with the antigen and activate complement which damages cells, e.g. penicillin- or methyldopa-induced haemolytic anaemia. 

IL-5 dependent conversion of normodense human eosinophils to the hypodense phenotype uses 3T3 fibroblasts for enhanced viability, accelerated hypodensity and sustained antibody-dependent cytotoxicity. J. Immunol. 143, 2311-2316. 

Rothenberg, M.E., Petersen, J., Stevens, RL., Silberstein, D.S., McKenzie, D.T., Austen, K.F. and Owen, W.F., Jr. (1989). IL-5-dependent conversion of normodense human eosinophils to the hypodense phenotype uses 3T3 fibroblasts for enhanced viability, accelerated hypodensity, and sustained antibody-dependent cytotoxicity. J. Immunol. 143, 2311-2316. 

Immediate hypersensitivity Hay fever, urticaria, atopic asthma Antibody-dependent cytotoxic hypersensitivity Immune complex mediated hypersensitivity (Arthus reaction)... 

The fundamental immunological statement, that Antibody-dependent cytotoxicity (ADC) by normal non-T lymphoid cells bearing receptors for complement and... 

The fact that neither Cy2 nor C 3 alone exhibits binding activity is similar to the results obtained with Ig binding to K cells (Section IIIB2). As discussed previously, it has been shown that neither the Cy2 nor the Cy3 domain exhibits any activity in inhibition of antibody-dependent cytotoxicity. Michaelsen et al. (1974) have suggested that this can be due to a requirement for the juxtaposition of the Cy2 domains, a structure maintained not by the noncovalent interactions between themselves but rather by interactions between the two Cy3 domains. Loss of the Cy3 domain would result in the formation of monomeric Cy2, which interacts very weakly. Alternatively, of course, it could simply mean that both domains share in the site. Further work is necessary to differentiate these two alternatives. 

Gould HJ, Mackay GA, Karagiannis SN, O Toole CM, Marsh PJ, Daniel BE, Coney LR, Zurawski Jr, VR, Joseph M, Capron M, et al. Comparison of IgE and IgG antibody-dependent cytotoxicity in vitro and in a SCID mouse xenograft model of ovarian carcinoma. Eur J Immunol 1999 29 3527-3537. 

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