Bobolstemma paniculatum

As already shown, tubeimoside 1 (5) from Bobolstemma paniculatum exhibited a strong anti-tumor activity, but had intriguingly a potent antitumor-promoting effect in two-stage mouse skin tumor formation induced by DMBA+TPA [38]. Its natural analog, tubeimoside III showed also a potent anti-tumor-promoting effect in the same model after topical administration but not after oral administration [39]. 

Tubeimoside 1 (5) from Bobolstemma paniculatum was found to inhibit both core protein p24 production and HIV-mediated cytopathogenesis with EC50 of 24.1 and 22.9pg/ml respectively. It was concluded that tubeimoside 1 had an inhibitory action on the infection of HIV-1 isolates and would be a promising candidate for the treament of AIDS [150]. 

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